مولانا عبدالسمیع
گزشتہ ماہ کاالم ناک سانحہ دارالعلوم دیوبند کے قدیم تر استاذ حضرت مولانا عبدالسمیع صاحب ؒ کی وفات ہے۔مولانا مرحوم کئی ماہ سے علالت کے امتداد واشتداد کی تکلیفیں اٹھا رہے تھے، بالآخر ۱۰/صفر المظفرکو ہمیشہ کے لیے اس جہان فانی سے رخصت ہوگئے۔
مرحوم حضرت مولانا میاں سید اصغر حسین صاحبؒ کے مخصوص ہم سبقوں میں تھے اوربزرگوں کی خوبیوں اورخصوصیتوں کے جامع، بڑے با وضع، بڑے سادہ مزاج اوردارالعلوم کے اساتذہ میں بعض اوصاف کے لحاظ سے بے عدیل و بے مثیل۔ پیرانہ سالی اورغیر معمولی نقاہت کے باوجود جب درس دیتے تھے تو معلوم ہوتا تھا کوئی تازہ دم اور بلندآواز مدرس پورے شوق و انہماک کے ساتھ طلبہ سے مصروف تخاطب ہے۔ مولانا کا طرزتعلیم عام فہم بھی تھا اوردل پذیر بھی، پڑھاتے پڑھاتے بہت سی کتابوں کے حافظ ہوگئے تھے۔اُن کے تلامذہ میں آج بڑے بڑے مدرس بھی ہیں اورباکمال مصنف اورانشاء پرداز بھی۔ ندوۃ المصنفین کے تقریباً تمام بڑے بڑے رفقاء کوآپ سے شرف تلمذ حاصل ہے۔اﷲ تعالیٰ مرحوم کے مراتب بلند فرمائے۔ہمیں اس حادثۂ عظیم میں مولانا مرحوم کے اکلوتے صاحبزادے مولوی عبدالاحد صاحب مدرس دارالعلوم دیوبند سے دلی ہمدردری ہے اورہم اُن کے شریک غم ہیں۔ امید ہے مولوی صاحب موصوف اپنے والد کے صحیح قائم مقام ثابت ہوں گے۔ [فروری ۱۹۴۷ء]
Osteopenia is regarded as the Bone Mineral Density (BMD) which is lower than that of the average value but not as low as Osteoporosis. In Pakistan, Osteoporosis and Osteopenia among women have become one of the most common problems of recent times. Objectives: To find the frequency of osteopenia among females in Faisalabad and its association with SES (Socio Economic Status). Methodology: It was an analytical and cross-sectional study which was conducted at Niaz Medicare Clinic in Faisalabad. The study was completed in 9 months from 18 October 2019 to 18 July 2020. Non probability purposive sampling was done and 323 females were taken for the study. Results: The results demonstrated that 56.3% of the population had Osteopenia. Socio Economic Status had as statistically significant association with Osteopenia (p= 0.041). The results also revealed that the females belonging to middle class and lower class had a higher prevalence of Osteopenia than the females of upper Socio Economic Status. Conclusion: the frequency of Osteopenia was fairly high among females specifically the age group 18-29 years. There was an association found between Osteopenia and Socio Economic status (p =0.041).
The research work embodied in the present dissertation deals with isolation, characterization and evaluation of biological activities of Indigofera heterantha, Millettia ovalifolia, and selected conifers which are presented in five parts along with a brief review of the biosynthesis of terpenoids, flavonoids, indigoferamide, indigoferate, indigoferone, millettio peroxide and sesquiterpene. PART- A Part A describes the phytochemical and biological evaluation of Indigofera heterantha (Wall). Three new and seven known compounds have been isolated from I. heterantha. Various experimental techniques and extensive spectroscopic studies were used for the isolation and structural elucidation of these compounds. Indigoferamide-A and indigoferate showed significant activity, against selected bacteria, while indigoferone exhibited high lipoxygenase activity. New Chemical Constituents · Indigoferamide-A (12) · Indigoferate (13) · Indigoferone (14) Known Chemical Constituents · Dotriacontanoic acid (15) · Formononetin (16) · Quercetin (17) ii· Quercetin 3-α-L-fucopyranoside (18) · 3,5,7-Trihydroxy-6,4’-dimethoxyflavon (19) · 3,5,4 ́-Trihydroxy-6,7-dimethoxyflavone (20) · Norartocarpetin (21) · 4-Hydroxy-4-methyl-2-pentanone (22) PART- B Part B focused on isolation, purification, characterization and biological evaluation of the chemical constituents of Millettia ovalifolia. Millettioperoxide along with five known compounds have been isolated and characterized through physical characteristics and extensive spectroscopic studies. The new compound possessed high anti-bacterial activity. New Chemical Constituents · Millettioperoxide (23) Known Chemical Constituents · 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one (24) · (E)-Ethyl 13-(3,4-dimethoxyphenyl) acrylate (25) · (E)-Methyl 3-(3,4-dimethoxyphenyl) acrylate (26) · N-Ethylacetamide (27) · Benzoic acid (28) iiiPART- C Part C deals with the isolation and characterization of the chemical constituents of Abies pindrow, which led to the isolation and structure elucidation of one new and four known chemical constituents. New Chemical Constituents · Abiespindrowpine (29) Known Chemical Constituents · β-Sitosterol (30) · β-Sitosterol 3-O-β-D-glucopyranoside (31) · 3β, 28-Dihydroxylup-20 (29)-ene (betulin) (32) · 3β-Hydroxylup-20 (29)-ene-28-oic acid (betulinic acid) (33) PART- D Part D explains the isolation and characterization of phytochemical constituents of Pinus wallichiana. Four known compounds have been isolated and characterized. Known Chemical Constituents · β-Sitosterol (30) · β-Sitosterol 3-O-β-D-glucopyranoside (31) · 5-Hydroxy-7-methoxy-2-(4-methoxy phenyl)-4H-chromen-4-one (34) · Oleanolic acid (35) ivPART- E Part E of the dissertation, described the isolation and structure elucidation of the chemical constituents of Piceae smithiana. Two known compounds have been isolated and characterized. Known Chemical Constituents · β-Sitosterol (30) · β-Sitosterol 3-O-β-D-glucopyranoside (3