۲۰۰۹ء میں جب میں نے سرگودھا یونیورسٹی میں ایم۔ فل اُردو میں داخلہ لیا تو اُسی وقت سے ہی سیالکوٹ کے شعر و ادب کی تاریخ لکھنے کا خیال میرے ذہن میں تھا اور یوں بھی زمانہ طالب علمی سے جب میں مرے کالج سیالکوٹ میں بی۔اے کا طالب علم تھا تو میری دلچسپی سیالکوٹ اور اس کے گردو نواح میں تخلیق پانے والے شعر و ادب اور اس علاقے کی تاریخی ،سیاسی ، سماجی و تہذیبی اور جغرافیائی اہمیت سے تھی۔ میں نے جس ماحول میں آنکھ کھولی وہ خطۂ سیالکوٹ کا روایتی ماحول تھا۔ یہ خیال آتا تھا کہ قدیم ترین خطۂ سیالکوٹ میں وقت کے ساتھ ساتھ جو تبدیلیاں رونما ہوئیں اور خاص طور پر جنھوں نے اس علاقے کے شعر و ادب کو متاثر کیا۔ اس کے بارے میں تحقیق ہونی چاہیے۔ اس سلسلے میں سب سے پہلے میں نے ۲۰۱۰ء میں سرگودھا یونیورسٹی میں ایم۔فل اُردو کے لیے تحقیقی مقالے ’’سیالکوٹ میں اُردو شاعری کا ارتقا ۱۹۴۷ء تا ۲۰۰۹ء ‘‘ کا انتخاب کیا۔ اس تحقیقی و تنقیدی مقالے میں شعرائے سیالکوٹ کے سوانحی حالات اور ان کی شاعری کا تحقیقی و تنقیدی جائزہ لیا گیا ہے۔ اس مقالے میں تشنگی رہہ گئی تھی کیوں کہ اس میں شاعری کی مکمل ادبی تاریخ کا بھی صحیح معنوں میں تحقیقی و تنقیدی جائزہ نہیں لیا گیا تھا۔ ضرورت اس امر کی تھی کہ سیالکوٹ کے شعری ادب کے ساتھ ساتھ نثری ادب کا بھی مکمل طورپر تحقیقی و تنقیدی جائزہ لیا جائے ۔اس عظیم کام کو سر انجام دینے کے لیے تحقیق کار نے ۲۰۱۲ء میں یونیورسٹی آف سرگودھا میں پی۔ایچ ڈی اردو میں داخلہ لیا۔ ۲۰۱۴ء میں یونیورسٹی نے ’’سیالکوٹ میں نقدو ادب کی روایت‘‘ عنوان کے تحت ریسرچ پروپوزل پی ایچ ڈی اُردو مقالے کے لیے منظور...
Peace has great importance both for the individual and the communal life. Wherever peace turned into unrest, the tendencies of social violence, mental sickness and insecurity start developing amongst the people. Peace and harmony were the hallmark of the reign of the 2nd caliph, Haḍrat ‘Umar. He gave the best governing mechanism to the people of Arab, when they were not fully aware of rules & regulation of government. Though the empire was wide spread, he exercised a great sort of command & control on it. He took the responsibility of providing his subjects their basic needs: Food, Shelter, Education, Peace and Justice. This was not only an ideal system of its time but became the role model for the modern welfare state. Peace and harmony is as important for a state as food & air are for life. Allāh has strongly emphasized in The Holy Qur’ān" on two things i. E., "Disharmony & hunger" which should be eliminated from a society. Haḍrat ‘Umer during his reign of 10 years presented Islām as a religion of peace & harmony, a religion, which respects humanity, peacefully resolves disagreements and curtails misuse of power. He himself possessed the qualities of peace & harmony to an utmost level, which were the traits of our Holy Prophet’s (ﷺ) personality. It is important to follow the Khilāphah of Haḍrat ‘Umar to bring peace & justice in the society.
OBJECTIVE: To study the capability of bioactive compounds to ameliorate the neuronal destruction in animal model of Parkinson disease. MATERIALS AND METHODS:Rotenone was used to produce the Parkinsonism in mammalian model of rats and the bioactive compounds, chrysin, polydatin and CGA were used to ameliorate the neuronal destruction and the resulting effets of Parkinson in this study. A total of hundred male Sprague Dawley albino rats of weight 200 to 250 gm were divided randomly into five groups with twenty animals in each: control, rotenone+chrysin, rotenone+polydatin and rotenone+chlorogenic acid (CGA) group. Rotenone was dissolved in DMSO and migloyl 812 N at ratio of 2:98 respectively and was administered intraperitoneally at a dose of 3 mg/kg, daily for four week to produce the rat model of Parkinson disease. Mortality and weight changes were assessed, various behavioral tests were performed throughout the experiment to assess the neuro behavioral changes. At the end of experiment, animals were sacrificed, brains were fixed by perfusion method and light microscopic sections were prepared using H & E and cresyl violet method. Immunohistochemical sections were also prepared using anti tyrosine hydroxylase antibody, anti α synuclein antibody, anti ubiquitin antibody, to localize the damaged neurons and amelioration done by bioactive compounds. Anti GFAP antibody was used to localize the Astrocytes immunohistochemically. Dopaminergic neurons, α synuclein and ubiquitin aggregations and astrocytes were analysed for anychanges in their morphology and count in substantia nigra and striatum in Parkinsonism and the ameliorating effects of the bioactive compounds used in this study on them. RESULTS:Rotenone-induced Parkinsonism in animals showed a significant loss of body weight and increase in mortality.Parkinson animals showed deteriorating motor behaviour over the period of experiment. Parkinson animals showed a decrease in dopaminergic neurons in nigrostriatal region. TH immunohistochemistry (IHC) showed decreased immunoreactivity and number of TH positive dopaminergic neurons.Ubiquitin and α-synuclein IHC showed accumulation of α-synuclein & ubiquitin within the neuronal cytoplasm. Astrogliosis with increase in number and amoeboid morphology was also seen. Bioactive compounds not only significantly restored the rotenone-induced weight loss but also the behavioural changes. These compounds also showed protective effects in terms of less degeneration of nigrostriatal dopaminergic neurons and diminished immunoreactivity to anti ubiquitin and anti α-synuclein antibodies. These compounds also decreased the activation and number of astrocytes. CONCLUSION:This study concludes that bioactive compounds confer protection in rat model of Parkinson disease. They ameliorated the degeneration of the dopaminergic neurons, accumulation of α-synuclein and ubiquitin in the cytoplasm of neurons and activation & morphological alteration of astrocytes.