حکیم محمد زماں حسینی کاانتقال
یہ کس کومعلوم تھا کہ بیسویں صدی جاتے جاتے بھی امت مسلمہ کوایسا صدمہ دے جائے گی کہ جس سے امت مسلمہ عرصہ دراز تک ابھر نہ سکے گی۔عالم دین،مفسرقرآن،مصنفِ اسلام، مدبر ومفکر حضرت مولانا حکیم محمد زماں حسینی رمضان المبارک کے مقدس مہینے میں اس عالم فانی سے رخصت ہوکرعالم بقاء میں پہنچ کر مالک حقیقی سے جاملے۔اناﷲ واناالیہ راجعون۔
ان کے انتقال پرملال پرتعز یت پورے عالم اسلام میں کی جائے گی۔اس لیے کہ ان کی شخصیت کے اٹھ جانے سے تمام عالم اسلام کوصدمہ پہنچا ہے،نقصان ہواہے۔ان کی زندگی عالم اسلام کی خدمت کے لیے جیسے وقف تھی۔انہوں نے اپنی تحریروں،تقریروں اور تصانیف کے ذریعہ عالم اسلام کی سچی رہنمائی وخدمت کی ہے۔وہ بے لوث اورمخلص تھے کسی جاہ ومنصب سے بے نیاز صرف دین کی خدمت میں ہی ان کوسکون واطمینان اورراحت وخوشی حاصل تھی۔شیخ الاسلام حضرت مولانا سید حسین احمد مدنی ؒ کے خصوصی تلامذہ میں سے تھے۔صحیح فکر تھی، سوچ میں سچائی تھی،بلند کردار کے حامل تھے،سادگی رگ وریشہ میں سرایت کی ہوئی تھی۔رئیس الاحرار مولانا محمد علی جوہر کی طرح جوش وجذبہ سے طبیعت بھری ہوئی تھی۔حضرت مولانا عبدالماجد دریابادی کی طرح وسیع النظر تھے اورحضرت مولانا سید ابوالحسن علی ندوی کی علمی صحبت ومجلس سے فیض یافتہ تھے۔مفکر ملت حضرت مفتی عتیق الرحمن عثمانی کے جاں نثار شیدائی شاگردوں میں بھی ان کاشمار ہوتاتھا۔حضرت مفتی عتیق الرحمن عثمانی ان کے علم وفکر کے معترف وشناسا تھے۔ سیرت پاک پرحضرت مولانا حکیم محمد زماں حسینی صاحبؒ کی تقاریر سننے سے تعلق رکھتی تھیں۔ہندوستان کے وزیر اعظم راجیو گاندھی سیرت پاک کے جلسے میں ان کی تقریر سننے کے لیے شروع سے آخر تک بیٹھے رہے اوررسول پاک ﷺ کی روزمرہ زندگی کے تمام واقعات،پڑوسیوں سے حسن سلوک،غیر مسلموں سے بہترین برتاؤ،دشمنانِ اسلام سے نبی اکرم...
It is with profound pleasure that we write this editorial to welcome you to the new journal, “Pakistan Biomedical Journal” (PBMJ), an interdisciplinary international journal. PBMJ has successfully completed its first volume and now its the second volume. We greatly appreciate the response of scientists who have contributed previously and are still contributing to this new journal. The subject of the journal is interesting and we try to address the health related concerns of public and improve the understandingof scientific phenomenons by researchers. Research discoveries are happening at a fast pace, in all the fields and PBMJ provides an ideal forum for exchange of scientific knowledge in terms of full length papers, surveys, reviews, case studies, letters to editor and systematic analysis. PBMJ is committed to publishing all manuscripts receiving a high recommendation from reviewers. The intention of PBMJ is to create space for generation of new knowledge, debate, collaborations among national and international scientists. Our vision is to promote research that will be helpful for knowledge sharing, new discoveries, development of critical thinking among the upcoming scholars, guidance for policy makers, awareness among the concerned community and ultimately benefitting the general population in improving health and fitness at large. It is a matter of pride for us to haveexcellent editorial board members from renowned institutes. We aim to have the best standards of quality of the published manuscripts. With every issue, we are continuously trying to improve the standards. We look forward for more exciting researches and scientific studies from all over the world. We would like to extend a very warm welcome to the readers of PBMJ and hope you will join us as authors, reviewers and editors in future.
In the present study, 52 different homoleptic and heteroleptic Pd(II) complexes were synthesized by reacting palladium(II) chloride with substituted triphenylphosphine and sodium salts of dithiocarbamates namely in a mixture of dry solvents. The ligands and various substituted triphenylphosphines used were sodium 4-benzylpiperazine-1-carbodithioate (L-1), sodium 4-diphenylmethylpiperazine-1-carbodithioate (L-2), sodium 4-(2-methoxyphenyl)piperazine-1-carbodithioate (L-3), sodium 4-(3-methoxyphenyl)piperazine-1-carbodithioate (L-4), sodium 4-benzylpiperidine-1-carbodithioate (L-5), sodium 4-(2-pyridyl)piperazine-1-carbodithioate (L-6), sodium 4-(2-pyrimidyl)piperazine-1-carbodithioate (L-7), sodium 4-(2-furoyl) piperazine-1-carbodithioate (L-8), sodium 4,4''-trimethylenedipiperidine-1-carbodithioate (L-9), tris(p-chlorophenyl)phosphine, tri-p-tolylphosphine, diphenyl-p-tolylphosphine, 1,4- bis(diphenylphosphino)butane, and tris(4-flourophenyl)phosphine. The coordination mode of ligands toward Pd(II), structural confirmation and geometry assignment of the complexes were made, using different analytical techniques such as elemental analysis, FT-IR, multinuclear (1H, 13C and 31P) NMR and X-ray single crystal analysis. Based on results, the ligand appeared to coordinate the Pd(II) atom through CSS moiety. The homoleptic and heteroleptic Pd(II) complexes demonstrate perfect square planner and distorted square planer geometries, respectively. The synthesized complexes were screened for in vitro cytotoxic activity against six different cell lines, LU (Lungs cancer cell lines), MCF-7 (mammary adenocarcinoma cell), 1c1c7 (murine hepatoma cells), PC-3 (prostate carcinoma), MDA-231 (estrogen-independent breast cancer cells) and HeLa (cervical carcinoma cell) by the MTT {Tetrazolium [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} method. The homoleptic Pd(II) was less active whereas heteroleptic Pd(II) complexes composed of bidentate 1,4-bis(diphenylphoshino)butane, flouro and uncoordinated group (carbonyl and nitrogen) was found to be most active against different cancer cell lines as compare to the standard drug (Staurosporine and cisplatine). The interaction of the selected Pd(II) compounds with DNA was investigated by UV-Vis spectroscopy. The hypochromic effect for all the selected Pd(II) complexes was observed, indicating intercalative mode of interaction of these complexes with DNA. The antioxidant activity of selected Pd(II) complexes were evaluated using DPPH as a free radical and Ascorbic acid as a standard. Most of the complexes showed higher antioxidant property than the standard. The selected Pd(II) complexes were also evaluated to check their cytotoxicity and phytotoxicity using brine shrimp assay and seedling growth of maize, respectively. The highest activity was shown by compounds containing oxygenated species (19). Selected complexes were also screened for their antibacterial and antifungal activities against various strains of bacteria and fungi, and were found active.