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The Golden Period of Beaux &Amp; Baroque Architecture [Ba Fashion Design]

Thesis Info

Author

Farrah Fayyaz

Department

Umt. Department Textile

Program

BA

Institute

University of Management and Technology

Institute Type

Private

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Page

83 . CD

Subject

Textiles

Language

English

Other

Eng; Call No: TP 677.02272416 FAR-G

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676713920287

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اکرامؔ سانبوی

اکرامؔ سانبوی (۱۹۴۲ء۔۲۰۱۱ء) کا اصل نام محمد اکرام ہے۔ آپ ریاست جموں کشمیر کے سرمائی صدر مقام جموں میں پیدا ہوئے۔ آباؤ اجداد کا تعلق ضلع جموں کی تحصل سانبہ سے تھا۔ اسی لیے اکرام سانبوی کہلاتے تھے۔ قیام پاکستان کے بعد جموں سے ہجرت کر کے سیالکوٹ کے محلہ پورن نگر میں آباد ہوئے۔ آپ نے ایم ۔اے اردو اورنیٹل کالج لاہور سے کیا اور اس کے بعد جناح اسلامیہ کالج سیالکوٹ میں اردو کے لیکچرا ر کی حیثیت سے آپ کا تقرر ہوگیا۔(۹۸۷)

اکرام ؔغزل اور نظم کے شاعر ہیں۔ کالج کے زمانے میں انھوں نے کئی مزاحیہ مضامین اور افسانے لکھے جو کالج میگزین کے علاوہ کئی سطح کے ادبوں رسالوں میں شائع ہوئے۔ تنقیدی مضامین اور خصوصاً شاعری کا شوق بڑی عمر میں ہوا۔ اس لحاظ سے ان کی شاعری کی عمر کچھ زیادہ نہیں تاہم ان کے کلام سے ظاہر ہوتا ہے کہ ان میں ایک اچھا شاعر بننے کی پوری صلاحیت ہے۔ اکرامؔ کے کلام میں ہمیں گہرا سماجی شعور ملتاہے۔انھوں نے بڑی خوبصورتی سے اپنی شاعری میں اپنے ماحول کی شعری زبان میں عکاسی کی ہے ۔اور اس کے ساتھ ساتھ اپنے وقت کے مسائل کو بھی بڑی عمدگی سے پیش کیا ہے۔ ان کے ہاں ہمیں افسردگی اور بے چینی نظر آتی ہے۔ جو ان کے دل کی دنیا کی بھر پور عکاسی کرتی ہے:

ہر طرف یاس کا اندھیرا ہے

 

/زندگی ہو گی اب بسر کیسے

 

-بے ثمر ہو گئے شجر کیسے

 

-بے صدا ہو گئے نگر کیسے

(۹۸۸)

 

 

 

 

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The Relationship Between Competence and Job Satisfaction on the Performance of Private Madrasah Tsanawiyah Teachers in the City of Surabaya

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Anthraquinone Sulfonamides and Derived Heterocycles: Design, Synthesis, Biological Evaluation and Computational Studies

Leishmaniasis, a worldwide prevalent disease, is still enjoying the ruling with no proper medication; and to add to this current gloomy scenario the disease causing parasite Leishmania is becoming resistant to the ongoing medication that is being practiced now a days. Hence, the need is to search for reasonable, safe and targeted drugs; the present research is one such effort in this direction. To begin with, Leishmanolysin (GP63), zinc metalloprotease, expressed over the surface of Leishmania species was selected as drug target due to its virulence and reason for parasite resistance. A library of benzimidazole derivatives (1-37) was synthesized and screened for its antileishmanial potential against L. major. All the compounds were found potent antileishmanial with IC50 values in the range of 0.62-0.92 μg/mL as compared to amphotericin B (standard drug) IC50 value 0.56 μg/mL. 2-(Thiophen-2-yl)-1H- benzimidazole (19) and 2-(1H-indol-3-yl)-5-nitro-1H-benzimidazole (34) were identified as the lead compounds of the library with IC50 value of 0.62 μg/mL. ADMET properties of the entire library were also predicted by using ADMET PredictorTM and were observed to be safe. Molecular docking studies carried out on all the members of library and amphotericin B by using MOE software, indicated that the most active compounds fitted at the centre of binding pocket of GP63 built by amino acid residue His264, His268, His334 and Zn578. On the basis of molecular docking results, receptor based pharmacophore model was built containing three Aro|Hyd features and one Acc&ML feature. This pharmacophore model was used to design new scaffolds for antileishmanial compounds. Four libraries, 2-(2- aryl/heteroarylbenzimidazol-1-sulfonyl)anthraquinones (38-69), N-(heteroaryl)-anthraquinon-2- sulfonamides (70-95), aryl anthraquinon-2-sulfonates (96-111) and N-(anthraquinon-2-sulfonyl)-amino acid methylesters (112-123) were designed and all the cmpounds were found as hit by pharamocophoric search. Their antleishmanial activities were predicted by QSAR model; built by MOE software by selection of 94 descriptors and partial least square (PLS) method on experimental antileishmanial activity of 37-mebered library and amphotericin B, validated by internal and exernal test sets with correlation coefficient (R2) 0.7762. All the compounds belonging to four libraries (38-69, 70-95, 96-111 and 112- 123) were found potent antileihmanial with predicted activity in the range of 0.5435-0.9940. All the compouds were observed safe according to predicted ADMET properties and Lipinski’s rule of five (Ro5). Later, these four designed libraries were synthesized and characterized by physical constants and spectroscopic techniques for onward screening for their antileishmanial potential against L. major by using amphotericin B as standard control which confirmed that all the compounds were potent antileishmanial. Compliance of the predicted activity by QSAR model with observed activity from in vitro antileishmanial activity resulted in identification of the same lead compounds in each library 38-69, 70-95, 96-111 and 112-123 i.e. 2-(5-Nitro-4-methoxyphenyl-1H-benzimidazol-1-sulfonyl)anthraquinone (61) (predicted activity 0.6794, IC50 0.67 μg/mL), 2-(1H-benzo-1,2,3-triazol-1-sulfonyl)anthraquinone (91) (predicted activity 0.5579, IC50 0.57 μg/mL), 2-(1H-pyrazol-1-sulfonyl)anthraquinone (90) (predicted activity 0.5435, IC50 0.58 μg/mL), benzyl anthraquinon-2-sulfonate (100) (predicted activity 0.7615, IC50 0.76 μg/mL) and N-(anthraquinon-2-sulfonyl)-2-phenylglycine methylester (123) (predicted activity 0.7305, IC50 0.75 μg/mL). Pharmacophore based molecular docking studies carried out on all the eighty six compounds on GP63 by MOE software showed hydrophobic interactions, hydrogen bonding and metal ligation interactions with His268, His264, His334 and Zn578, respectively. This entire set of experiments in both dry and wet labs led to a successful designing of a variety of anthraquinon-2- sulfonamides as a novel scaffold having strong antileishmanial effect.