Victory of the Holy Prophet (P. B. U. H) over the People of Makkah

The Prophet (P.B.U.H), born in 571 A.D at Makkah, came to enlighten this world with divine guidance and to transform this world from the clutches of immoralities and sins to pinnacle of piety and ethics. He lived in this world for almost 63 years and brought revolutionary changes which no one even could think of. But this task was not easy, he suffered the most and sacrificed everything to raise and proclaim the words of Allah. He set an example for others to follow. This article is all about his life in Madinah with regard to his dealing with the arch enemies of Islam who were his own natives “The Makkans”. Prophet (P.B.U.H) settled in Madinah and established Islamic society so as to enable everyone to spend life in accordance with the divine guidance. Here, he signed treaty with the Jews created Muakhaat for Mohajirin and Ansars. On the other hand, Makkans could not stand this development. So, they imposed battles on Muslims and Muslims had no options except Jihad. The Holy Prophet (P.B.U.H) fought many battles with Makkans. However, no innocent was executed during these incidences. This shows the dynamic teachings of Islam.  This article gives brief events of these battles besides revelations which came to Prophet in the line of duty to motivate and guide Muslims. It took almost eight years for Prophet to excel Makkans.

Expression of Mismatch Repair Proteins in Colorectal Cancer at Aga Khan University Hospital, Nairobi

Introduction: Microsatellite instability is one of three molecular pathways described in the pathogenesis of colorectal carcinoma. The presence of microsatellite instability in patients with colorectal cancer has implications for prognosis and family counselling. Deficiency in mismatch repair genes leads to microsatellite instability and this can be reliably demonstrated in formalin fixed paraffin embedded tissue by methods, which include immunohistochemistry for the detection of mismatch repair proteins. Local data show a disproportionately large number of younger patients with colorectal cancer compared to that documented in Caucasians. Colorectal cancer in younger ages is often attributed to deficient mismatch repair. The objective of this study therefore, was to determine the proportion of colorectal cancers associated with the microsatellite instability pathway through detection of the mismatch repair proteins on immunohistochemistry. Materials and Methods: This was a retrospective study of 80 colorectal adenocarcinoma resection specimens received over a three-year period from January 2009 to January 2012. The mismatch repair gene mutation expression was analysed by immunohistochemical staining for products of mismatch repair genes. Associated clinical and pathologic characteristics were reviewed and documented. Results: The proportion of deficient mismatch colorectal cancer in the study was 19.4% [95% CI 11.7%-30.4%].There was a significant but weak association between mismatch repair gene protein expression and tumour grade, and tumour infiltrating lymphocytes (tumour grade Cramer’s V=0.263, p=0.031; tumour infiltrating lymphocytes Cramer’s V=0.246, p=0.044). Mismatch repair gene protein expression outcome showed significant but moderately strong association with the anatomic site of tumour, and tumour histological type (anatomic site Cramer’s V=0.469, p=0.001, tumour histological type Cramer’s V=0.469, p=0.001,). Conclusions: The study provides preliminary data of the contribution of the deficient mismatch repair molecular pathway of colorectal cancer in Kenya.