23. Al-Mu’minun/The Believers
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
23:01
a. Indeed, The Believers will succeed.
23:02
a. The Believers are those who humble themselves in their Salat/Prayers,
23:03
a. and those who avoid frivolous talk and behavior,
23:04
a. and those who regularly pay out the Zakat/annual charity,
23:05
a. and those who guard their chastity -
23:06
except from their spouses or from those whom their right hands possess -
for then, indeed, they are free from blame.
23:07
a. But whoever seeks beyond that limit, those - they are the transgressors,
23:08
a. and those who faithfully keep their trusts, pledges, contracts, and promises,
23:09
a. and those who guard their Salat/Prayers from worldly distractions.
23:10
a. It is they - they are the inheritors -
23:11
who will inherit the Paradise of Firdaws,
they will live therein forever!
23:12
And, indeed, WE created the human being out of the essence of clay.
23:13
Thereafter, WE made him as a mingled drop in a secure repository of the female’s womb.
23:14
And, then, WE made an embryo/clot from the drop,
and then WE made a lump from the embryo/clot,
and, then, WE made bones from the chewed-up lump,
and, then, WE clothed the bones with flesh and muscles.
And, then, out of that tiny drop, WE structured him into yet another creation.
So Exalted is Allah - the Best Creator of all creators!
All praises and thanks be to Allah, the Lord of the entire Universe Muhammad, who is a symbol of mercy, peace, and love to all human beings. Islam is a universal religion. Its blessings, bounties, and auspiciousness are common to all human beings irrespective of community, caste, creed, region, and nation. Islam is the religion of peace and mercy. It is a religion for humanity. It strongly emphasizes love and mercy in general. It teaches us that we should show mercy. R-?-M (Arabic: ?) is the tri consonantal root of many Arabic and Hebrew words, and many of those words are used in the Holy Quran. Holy Quran is a complete guide for all human beings. All chapters in the Quran, except one (Repentance Chapter), begin with the words “Bismillahiar-Rahman AR-Rahim” or in the name of Allah, Most Gracious, Most Merciful. IN Islam the title “Most Merciful” (al-Rahman) is one of the names of Allah and Compassionate (al-Rahim), which is the most common name occurring in the Quran. Rahman and Rahim both derive from the root Rahmat, which refers to tenderness and benevolence. Allah SWT could have used other attributes in its place, but he chooses these two which show their significance. God’s Mercy precedes his other attributes. Each worshipper repeats the attribute of mercy sixty-eight times/day during his five daily prayers. Without love and mercy, there will be chaos in society. Showing mercy to Allah’s creatures creates a society of peace and tolerance. That is why in Holy Quran Allah emphasized mercy and tenderness.
Present thesis describes the synthesis, characterization and biological screening of sulfonamide ligands; their complexes and five membered heterocyclic ligands (Thiohydantoin ligands); their complexes aiming in search of new candidates to fight with microorganisms. Thanks to metals for being the charm of medicinal and pharmaceutical chemistry since many decades. To extend this search, 20 ligands were synthesized. Ligands containing sulfonamide moieties are prepared by the reaction of ten different amino acids with p-toluene sulfonyl chloride. The compounds are isolated in pure form and checked by TLC. The single crystal structure of the compounds is also reported and dicussed.These compounds were then reacted with transition metals e.g, Zn (II), Sb (III) chloride and Sb (III) bromide and thirty new metal complexes have been synthesized. Further, these sulfonamide derivatives were cyclized in the presence of NH 4 SCN, acetic anhydride and base to form 5-membered heterocyclic ring containing thio group. Forty, new complexes of these thiohydantoins with transition metals e.g. Zn (II), Sb (III) chloride and Sb (III) bromide have been synthesized. All of the synthesized complexes were heat, air and moisture stable after formation, but during the complex formation, moisture and air was avoided to prevent the oxidation of the compounds using standard schlenk line and glove box techniques. The stability profile enhances the link between organometallics and drug design and discovery. Purity of all of the synthesized compounds was conventionally monitored with the help of TLC in different solvent systems. All of the synthesized compounds and their complexes with transition metals were characterized by elemental analysis, FTIR, GC- MS and 1 H NMR , 13 C NMR spectroscopy, the structure was finally confirmed with the help of single crystal structure. All the characterization data is reported in this work and discussed. All the synthesized compounds and their metal complexes were evaluated for their carbonic anhydrase, intestinal alkaline phosphate inhibition, antileshminial, anti oxidant, anticancer and antibacterial activities. The results of these bioassays are also reported and discussed in detail, e.g., the sulfonamide ligands showed excellent carbonic anhydrase activities, while the activity was enhanced 40-60% in case of zinc complexes but the antimony (III) complexes have showed slightly less CA activities. Similarly, the complexes of antimony with sulfonamide ligands have showed excellent antileshminial activities, while the zinc (II) complexes have showed comparatively less activities. Moreover, the results of intestinal alkaline phosphatase activities iiihave proved that the metal complexes of sulfonamide and thiohydantoin ligands have showed increased activities as compared to parent sulfonamide ligands. Additionally, the said complexes also showed enhanced cytotoxic activities against BHK-21 and H-157 cell lines. The antibacterial activity against Gram –ve and Gram +ve bacteria were outstanding in case of metal complexes of the sulfonamides. Results of antibacterial evaluation of all the compounds as percent inhibition against these bacteria are reported and discussed. The activity of different synthesized compounds as percentage inhibition against concentration and time are included and discussed in detail. We can summarize by saying that the newly synthesized ligands and their metal complexes have provided important candidates for drug discovery which can be further improved to be used as drugs with enhanced pharmacological action and lesser side effects.