مفتی محمد انوار الحق
بھوپال سے مفتی محمد انوار الحق صاحب ایم اے سابق وزیر تعلیم و حال وزیر مالیات بھوپال کی وفات کی افسوس ناک خبر آئی ہے، موصوف صاحب علم اور محب دین تھے، ان کی قلمی خدمات اور تحریری مجاہدات بھی خاص ذکر کے قابل ہیں، تاریخ ابوالبشر، اثبات واجب الوجود اور دوسری مذہبی کتابیں جدیدتعلیم یافتہ طبقہ کے لیے بہت مفید ثابت ہوئیں، عمر بھی علمی و تعلیمی کاموں کی مشغولیت کے باوجود اخیر عمر میں سرکار بھوپال کے مالیات کے صیغہ کو جس خوبی سے سنبھالا، دوست و دشمن ہر ایک نے اس کی تحسین کی، اﷲ تعالیٰ اپنے خزانہ رحمت سے اس علم و عمل کے مجسمہ کو سرفراز فرمائے۔
(سید سلیمان ندوی، جولائی ۱۹۴۰ء)
This research articulates the influence of advertising on consumer buying behavior for conspicuous products. Aim of conducting this study was to analyze the impact of advertising liking and advertising attitude on consumer buying behavior, mainly to investigate that either the advertisements are effective to convince the people to spend money on conspicuous products or to influence their buying behavior. Findings of this research will be beneficial to overcome the problem of advertisers focusing more on advertisements contents and effectiveness of advertisements. In order to investigate this, data was collected by showing different advertisements to the responders and it was asked for to fill up the questionnaire. According to our findings, there is a significant and positive influence of advertising on consumer buying behavior for conspicuous products. Which means that it contributes much in influencing consumer buying behavior through both national product advertisements and international products advertisements.
Background: Aluminum (Al) is known to be associated with etiology of different neurodegenerative disorders especially of Alzheimer’s disease (AD) and is known to produce AD like symptoms. It is widely reported that Al affects muscarinic acetylcholine receptors but limited data is available for its effects on nicotinic acetylcholine receptors (nAChRs). The aim of this study was to determine that how Al affects hippocampus, amygdala and cortex dependent learning and memory functions and expression of nAChRs and choline acetyltransferase (ChAT) genes. Effect of Al on cholinergic biomarkers i.e. free choline and acetylcholine (Ach) level were also investigated. Moreover acute effects of Al on nAChRs-mediated modulation of persistent gamma oscillations in hippocampus was also studied. Methods: In order to develop the AD mouse model, AlCl3.6H2O (250 mg/kg) was administered to mice in drinking water 42 days. After completion of Al treatment the learning and memory deficits were assessed via different behavior tests. nAChRs gene expression was determined via RT-PCR in cortex, hippocampus and amygdala. Inductively coupled plasma atomic emission spectrometry (ICP-AES) was used to measure Al accumulation in brain. To determine how Al affects gamma oscillations, field potential recordings were performed in CA3 area of acute hippocampal slices. Results: The results of this study demonstrate that oral Al ingestion caused high accumulation of Al in brain leading to neuropathological changes that suppressed expression of nAChR genes and caused neurodegeneration. Longer in-vitro Al exposure caused permanent changes in hippocampal oscillogenic circuitry and changed its sensitivity to nAChR-modulation, leading to deficits in memory and learning in AD mouse model. Moreover in spite of normal free choline availability Abstract xix Ach synthesis was reduced as a result of oral Al exposure. The reduced Ach synthesis is caused by impaired recycling of Ach due to lower expression of ChAT gene. The reduced Ach level causes deficits in cholinergic neurotransmission which leads to memory and cognitive deficits. Moreover, hippocampus is the most affected brain part after Al intoxication. This study suggests that interference with cholinergic neurotransmission can be the underlying mechanism through which Al causes memory and learning deficits and contributes to neuropathological changes leading to AD.