16. Al-Nahl/The Honey Bee
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
16:01
Allah’s Judgment is coming.
So do not seek to hurry it – O the disbelievers.
All Glory be to HIM!
And HE is Exalted - far above what they ascribe to HIM in Divinity and Worship.
16:02
Tell them, O The Prophet, that everyone does not deserve to get the angels descend on to him.
HE sends down the angels with the Spirit by HIS Command upon whoever HE
Pleases of HIS servants, saying:
‘Warn people that there is no entity of worship except ME alone.
So keep away from MY disobedience’ in reverence, awe, and piety!
16:03
HE created the celestial realm and the terrestrial world in truth with a definite purpose.
HE is Exalted - far above what they ascribe to HIM.
16:04
HE created the human being from a drop of semen,
yet the same human being openly becomes a fierce adversary.
16:05
And the livestock - HE created them for you.
There is warmth in them - in clothing from their hides/wool - and other benefits,
and of them, you obtain meat to eat as well.
16:06
And there is beauty in them for you too -
when you bring them home in the evening, and
when you take them out to pastures in the morning.
16:07
And they carry your loads to distant far-off lands,
which you could not otherwise reach without hardship to yourselves.
In fact, your Rabb - The Lord is All-Gracious and All-Compassionate.
16:08
And HE...
Our research paper is about to know that how Islamic work ethic (IWE) on organizational citizenship behaviors (OCBs), Knowledge sharing behavior (KSBs) and organizational commitment between workers of colleges of Hajeera, district Rawalakot, Azad Jammu Kashmir. We take 210 workers of different colleges from Azad Jammu Kashmir for the purpose of this study. Result indicates that Islamic work Ethics (IWE) plays a strong impact on Organizational Citizenship behavior (OCB). In short one with having high Islamic work Ethics (IWE) possess more organizational citizenship behavior (OCB) as one who possess low Islamic work Ethics (IWE). Our results are indicating (IWE) has a direct relationship with Knowledge sharing behavior (KSB). One with high Islamic work Ethics (IWE) possess high Knowledge sharing behavior (KSB) as one with having low Islamic work Ethics (IWE) possess low Knowledge sharing behavior (KSB). In this paper we will show you theoretical & practical implications of our results.
Present work refers to the design, synthesis, bioevaluation and computational studies of multifunctionalized dihydropyrimidines (DHPMs) known to possess immense pharmacological activities. A series of DHPM derivatives were synthesized by different strategies. In the first strategy, one pot Biginelli reaction was carried out using three building blocks (i.e. aryl aldehydes, 1,3-dicarbonyl compounds and diamino compounds). Hence three different types of DHPMs namely 4-aryl-3,4- dihydropyrimidine-2-ones (1-44), 4-aryl-3,4-dihydropyrimidine-2-thiones (45-69) and 2-amino-1,4-DHPMs (70-79) were synthesized. Through this strategy diversity was introduced at N1, C2, C4, C5 and C6 positions of pyrimidine nucleus. Moreover, keeping in view the difficulties during the synthesis of DHPM via Biginelli three component reaction, the conditions were optimized by doing these reactions through different modes such as sonication, microwave irradiation, as well as through conventional heating. Excellent yields without any side products were obtained under mild reaction conditions under sonication using a cheap catalyst i.e. SnCl 2 . Based on a simple nucleophilic displacement scheme, another set of 2-aminopyrimidines (83-87) was also synthesized. The second strategy involved modification of different functionalities of DHPM nucleus synthesized previously through one pot strategy. This led to introduction of different diversity elements farther at C5 and C6 positions leading to pyrimidines 88-92. Besides synthesizing a variety of pyrimidines, partial synthesis of ispinesib (a well known KSP inhibitor) was carried out via two routes with a view to optimize the reaction conditions and yield of the rate limiting step each of the two synthetic strategies. Since the synthesized dihydropyrimidines are anticipated to have important pharmacological properties, therefore, all these compounds were subjected to in vitro screening for studying their potential as urease inhibitors, xanthine oxidase inhibitors, thymidine phosphorylase inhibitors, potato disc tumor inhibitors and as antiglycation agents. Compound 53 was found to have very strong potential as urease inhibitor and may serve as a lead for developing into antiulcer drug. iiiIn silico studies were also carried out on the most active compounds identified in different bioassays by doing molecular docking and pharmacophore matching. Furthermore, in silico designing of DHPM based KSP, urease and thymidine phosphorylase inhibitors was carried out with a view to develop novel KSP, urease and TP inhibitors.