سرہڈسن کی وفات
گزشتہ دسمبر کا ایک اہم معاشرتی حادثہ سر رابرٹ ارنڈیل ہڈسن کی وفات ہے، سر ہڈسن انجمن صلیب احمر انگلستان کے صدر تھے اور انھوں نے انجمن کی ترقی و توسیع میں بہت کچھ حصہ لیا تھا اور اپنی بااثر شخصیت کی بناء پر اس انجمن کے لیے ایک کروڑ نوے لاکھ پونڈ جمع کئے تھے۔
کیا ہندوستان کی تمام انجمنوں کی متحدہ آمدنی بھی کبھی اس کے برابر ہوگی جس غریب ملک میں صحیح و تندرست لوگ بھوکے مرتے ہوں وہاں مریضوں کو کون پوچھتا ہے۔
(نجیب اشرف ندوی، مارچ ۱۹۲۸ء)
In the Holy Quran, Allah has mentioned many such social rules that are very important for the peace & stability of a society and welfare of human beings. This article will not only highlight the word “La'allakum” in terms of meaning, diction and eloquence but also explain its usage for different purposes. Apart from this, in this article light will be thrown on such social rules that have been defined under the word “La'allakum" along with its philosophy and their implementations in the present era.
The low solubility and permeability of drugs, in general, leads to unsatisfactory pharmacokinetics profile of drugs. Polymer conjugation has attracted increasing interest in pharmaceutical industry for delivering such low molecular weight (Mw) drugs as well as some complex compounds. The objective of this work was to find a method to overcome the solubility and permeability problems using the conjugation strategy. In this regard, hydroxyethyl starch (HES), a highly biocompatible semi-synthetic biopolymer, was used as a drug carrier. N- Arylsulfonylbenzimidazolones were selected as antidiabetic compounds of choice for coupling with HES. The experiments established the viability of a covalent coupling between polymer and N-arylsulfonylbenzimidazoles using a suitable coupling strategy. As a requirement for the desired coupled products, HES must have Mw that is suitable for drug delivery and excretion through the kidney. Therefore, HES needs to undergo a selective degradation. In the present study, two different methods for hydrolysis, i.e. acidic and enzymatic, were used for selective degradation of HES. It was found that the enzymatic hydrolysis method is superior to acidic hydrolysis. The enzymatic method was used to obtain HES of Mw as low as ≈ 10,000 g/mol. The selectively degraded HES was oxidized to generate carboxylic acid groups at the chain ends to serve as a coupling site for N-arylsulfonylbenzimidazolones, the selected antidiabetic compounds. For oxidation of HES, potassium permanganate and sodium oxychloride were tried as oxidizing agents. The sodium oxychloride method was found advantageous over permanganate method. The degraded and oxidized products were characterized using GPC, IR and NMR techniques. N-Arylsulfonylbenzimidazolones were synthesized using a multistep sequence to serve as antidiabetic compounds. The structures of all the synthesized arylsulfonylbenzimidazolne products and intermediates were established using spectroscopic techniques and the purity ascertained by elemental analysis. The synthesized arylsulfonylbenzimidazolnes were coupled to oxidized HES of molecular weights 17,490 g/mol and 10,067 g/mol by creating an amide linkage between the two units. iiThe coupled products were characterized using GPC, IR, 1 H NMR and 13 C NMR spectroscopy. The coupled products were screened for their antidiabetic potential on male albino rats of the Sprague–Dawley albino family at a dose of 20 mg and 40 mg per Kg body weight of the rats. It was observed that all the synthesized compounds were highly active. 2,3-Dihydro-3-(4- nitrobenzensulfonyl)-2-oxo-1H-benzimidazole (63) was found most potent with a 54 % reduction in blood glucose level of the rats as compared to 41 % reduction produced by tolbutamide and 38 % by glucophage. The coupling of these antidiabetic compounds with oxidized HES resulted in an increase of the hypoglycemic activity of all the compounds. The activity of compound 63 on coupling to HES 10,067 increased to 67 % reduction in blood glucose level.