الإمام ابن خزيمة و منهجه في صحيحه

Qur’an and Prophetic traditions (Hadith) are the fundamental sources of Islam. Muslims believe that Qur’an is the word of God (Allah). Hadith (Prophet’s Sayings, actions and silent approval and disapproval for something) likewise is based on divine revelation. Qur’an affirms also this view: (God says) Your Companion (Muhammad) has neither gone astray nor has erred. Nor does He speak of (his own) desire. It is only a Revelation revealed. Al-Qur’an (53: 2-4). Allah Almighty Himself took the responsibility to guard His word (the Qur’an): (He says : ) verily, we, it is We Who have sent down the Dhikr (i.e. The Qur’an) and surely, We will got it (from corruption). (Al-Qur’an: 15: 9) on the contrary the responsibility to guard the prophetic traditions (Hadith) was put on the shoulders on the Muslim Ummah. The scholars of Islam (Ulamas) try their utmost to collect and save the Prophetic traditions and guard it from any alteration. To achieve this purpose, they introduced different hadith sciences to distinguished between the true and the fabricated hadith. The authentic Sunnah is  contained within the vast body of Hadith literature. Different scholars have compiled the books which contain a large numbers of authentic Ahadith (Ahadith Sahiha), one of them is Imam Ibn e Khuzaima. In this article we will discuss the Imam Ibn e Khuzaima approach towards “Ahadith al Sahiha” in his book “Sahih Ibn e Khuzaima”.

Characterization of Inhibin Gene in Patientsof Polycysticovarysydrome

Polycystic ovary syndrome (PCOS) is multisymptomatic gynecological disorder with high prevalence (5-10%) among human females. Primarily it affects female reproductive system resulting in infrequent menstrual cycles. Visceral adiposity, insulin resistance, hirsutism and infertility are other consequences of PCOS. Genetic as well as environmental factors contribute for the progression of PCOS. Multiple studies revealed association of PCOS with mutations in different genes specifically expressing androgens and androgen receptors. PCOS is an autosomal and X-linked disease. 60-70% of PCOS patients suffer from hyperandrogenism i.e. high level of follicle stimulating hormone (FSH) & luteinizing hormone (LH). While LH/FSH ratio elevates in PCOS patients. Inhibin A downregulates the follicle stimulating hormone (FSH) to promote ovulation and regulate normal menstrual cycle. Inhibin A is a hetero dimer of INHA and INHB subunits. INHA along with Antimullerian hormone can be used as a diagnostic marker for PCOS. This study has been conducted using data of 50 participants. They were classified into two groups, control and experimental group. Out of total 50 participants, 30 were PCOS patients and 20 were healthy control subjects. Blood samples of PCOS patients were collected from Pakistan Institute of Medical Sciences. Extracted DNA from blood was used for amplification of exon 2 of INHA subunit of Inhibin A and B gene. Restriction digestion of Amplified gene segment was carried out with restriction endonuclease. Restriction fragment length polymorphism (RFLP) results showed 30% of PCOS patients having heterozygous mutation (G769A/ rs12720062). Results revealed positive risk of developing PCOS when having A allele at position 769bp in heterozygous state. So, we concluded that there is an association between heterozygosity at rs12720062 and risk of development of PCOS.