وہی ہم ہیں، وہی تم ہو، وہی دل کی تمنا ہے
تمھارے قرب کی سب خوشبوئوں کا بھید پانا ہے
تمھارے نام سے آباد ہے یہ بزمِ ہستی بھی
تمھارے دم سے ہی یہ موسمِ گل کا فسانہ ہے
وفائے گل کے سب قصے بھی ہیں منسوب تم ہی سے
تمھی سے بلبلوں نے عاشقی کا راز جانا ہے
نظر انداز کرنے کا ہنر تم نے کہاں سیکھا
بہت بیداد گر ہو تم، تمھیں اتنا بتانا ہے
زمینِ دل پہ آج اترو صبا ہے منتظر کب سے
فضاؔ بھی کیف پرور ہے بڑا موسم سہانا ہے
In sahih Bukhari the reform’s of Imam Bukhari are present in various styles and artistically sahih Bukhari is an eximious book. But in this present confab we want to disuses such a topic which is about the colligation of sahih Bukhari’s parts and order. The intellectual advisability and sequences called the order of the parlance, and some time many points are practical and various expediencies recondite in this order. With identity the object of the speaker is explicated e.g, he started the book with incipiency and it is brought first because the inspiration the provenance of admonition. He arranges “kitab-ul-Emam” of on the second because to have belief on Allah as “Rab” is the most preeminent and also the prerequisite. In the first Hdith انما الاعمال بالنيات is in the same order and we understand that candidness is not only enough in the outset but it should be obsessive on both the commencement and the verge. The advisability we understood is the deserts starts form intentness and suppress on the left. Imam Bukhari to words both radicals in the inception and completion of the book.
Liver is a principal organ that preserves the homeostasis of human body and performs many other functions including; detoxification of drugs, storing glycogen, regulating cholesterol and metabolism of urea. Liver injury induced by drugs is still a critical obstacle in the successful development of medicines. Acetaminophen (APAP) is an extensively consumed pain killer and is also the main cause of Drug Induced Liver Injury (DILI). An established biomarker for analyzing liver injury at molecular level is Cytochrome-P450 2E1 (CYP2E1) enzyme, mostly associated with the acetaminophen hepatotoxicity. Thus, a safer more reliable and economical way to deal with DILI is to determine an alternative use of the approved drugs. Binding of adrenergic ligands with their particular receptors is prevented by alpha-adrenergic blockers and is used in treating benign prostatic hyperplasia, cardiovascular disorders and erectile dysfunction. In this current proposal we have investigated whether terazosin (TER), an alpha adrenergic blocker, is effective as a hepatoprotective agent in an acetaminophen induced acute liver injury induced animal model. White New Zealand rabbits were used as animal models and were given an oral dose of acetaminophen to induce acute liver injury. It was observed that the Adenosine triphosphate (ALT) and Alkaline phosphatase (ALP) levels were much reduced by TER. ALT results showed statistical significance when compared with APAP alone. The serum ferritin level result was found to be decreased following the APAP intake. Lipid profile was much improved by TER as it decreased the level of Triglycerides (TG), Total Cholesterol (TC), Total Lipids (TL) and Low Density Lipoproteins (LDL) and increased the level of High Density Lipoproteins (HDL). TG level was statistically significant when comparing CON with both APAP and TER. Urea and creatinine level was also reduced indicating that TER acts as renal efficient agent. As CYP2E1 is upregulated during liver injury, it was observed that TER downregulated the expression level of CYP2E1. Hence, it can be stated that TER is not only safer for arterial hypertension but it is safe for human consumption. TER showed prevention of acute liver injury that was caused by acetaminophen, thus further studies can strengthen its alternative use in hepatoprotection.