سلطان ابن سعود
افسوس ہے کہ پچھلے دنوں عالم اسلام کی دو نامور شخصیتوں سلطان ابن سعود اور مولانا سید سلیمان ندوی نے اس عالم آب وگل کوخیرباد کہہ کر عالم آخرت کی راہ لی۔ حجاز کی سرزمین قدس مہبط وحی، حامل بیت اﷲ اور مولد و استراحت گاہ نبی (صلی اﷲ علیہ وسلم) ہے اوراسی بناپر اس کی خاک مسلمانوں کی جبین عقیدت وارادت کی افشاں اوراُس کا ذرہ ذرہ اُن کی آنکھوں کاتارا ہے۔ اس نسبت سے مسلمانوں کوسلطان مرحوم کے ساتھ بھی کہ وہ پاسبان حرم ہونے کا شرف رکھتے تھے، قلبی وروحانی تعلق تھا۔ اس کے علاوہ مرحوم میں ذاتی طورپر چند در چند ایسے اوصاف وکمالات تھے جن کے باعث تمام مسلمانوں کے دلوں میں اُن کی بڑی عزت وعظمت تھی۔عادات وخصائل،طبعی میلان ورحجان اورظاہر و باطن کے لحاظ سے وہ اور اُن کی حکومت متنبی کے اس شعر کے مصداق تھے:
حسن الحضارۃ مجلوب’‘ بتطریۃِِ
وفی البدواۃ حسن غیر مجلوب
مرحوم سیاسی اعتبار سے نہایت مدبر،بیدار مغز اورروشن دماغ ومستقل مزاج تھے۔ اُن کے عہد کا سب سے بڑاکارنامہ یہ ہے کہ حجاز صحیح معنیٰ میں بلداًا ٰمناً اور اس کا حرم درحقیقت مسلمانوں کے لیے حرم بن گیا۔انھوں نے فتنہ پرور و مفسد قبائل کی سرکوبی کرکے پورے ملک میں امن وامان اس طرح قائم کردیا تھا کہ ایک بڑھیا بھی تن تنہا اپنے مال واسباب کے ساتھ مکہ معظمہ تک بے خوف وخطر سفرکرسکتی تھی۔اس کے علاوہ مرحوم نے حرمین شریفین کے باشندوں کے لیے دینی و دنیوی تعلیم کابندوبست کیا اوراُن کی اقتصادی زبوں حالی جواُن کے لیے سب سے بڑی مصیبت تھی اُس کامداوا اس طرح کیا کہ آج وہاں فارغ البالی اور معاشی رفاہیت وخوش حالی کادوردورہ ہے۔حجاج کی راحت وآسائش کاسلطان مرحوم کو خاص خیال رہتا تھا اوراس سلسلہ میں وہ ایام حج میں صحت...
Mental disorders are common and contribute to the highest burden of disease across the globe. Depression and anxiety has become the most frequent disorder in these times. However, it is notconsidered a disease mostly and there are no proper policies and treatment all over the world but thedeveloping countries are affected the most. Mental health care services are lacking and inaccessible tomost of the patients worldwide. Apart from this fact, the stigma associated with this ailment is a majorhindrance in the way of treatment. Lack of human resource and their proper training is also lacking. Thereis a dire need to enhance research capacity to actually estimate the burden and magnitude of the problem, preparing a policy and above all, its implementation to bring a change in the treatment of mental healthproblems. Low and middle income countries are suffering the most due to these disorders and ironicallyit is not considered a disease thereMostly, the uneducated people attribute such mental health issues to supernatural phenomenonsuch as ghosts or magic etc. Additionally, for the treatment of these so-called “supernatural phenomenon”and to get rid of ghosts, they tend to go to “peers” or “baba” who are illiterate people, pretending to havecure for these patients. But infact, such malpractices and misconceptions among masses lead to adisastrous situation. It causes worsening of the condition of patient by not getting the proper medical andpsychiatric treatment, secondly, they are caught up by wrong people who extort huge amount of money. These are the challenges that developing countries are facing for the treatment of mental health issues. Evidence-based interventions and practice by trained personals in community and primary health carefacilities can improve the understanding and treatment of these ailments. Exercise, healthy life style, healthy dietary+ patterns and physical activities may also work wonders in these conditions.
No matter the large contribution of chemistry to the development in our large of dwelling, the negative and threatening photo of chemistry has been unfolded in human society due to adverse damage, consisting of large explosions in chemical factories in some instances. therefore, chemistry must development with the introduction of a at ease global in harmony with nature. high performance based on environmentally benign principles (green chemistry) is strongly required of synthetic natural chemistry in twenty first century. That’s why Emphasis here is placed on green synthesis of substituted benzamides and their solvent free conversion into substituted benzamidines interacting with transition-metals including their biological activities. Our primary objective is to create a greener reaction methodology that affords access to convert amide bond into N-substituted benzamidines and their metal complexes. For this first amide bond, has been synthesized through novel Dicobalt octacarbonyl catalyzed amidation of phenyl iodide, followed by anti-oxidant, anti- alzheimer, anti- urease and anti- fatigue activity. The capacity of these reactions through screening of different substrate and investigations into the mechanisms by way of which the reactions are working are also mentioned. The novel synthetic model of the amidine bond has been polished using CuO-np catalyzed conversion of substituted benzamide into N-substituted benzamidines. This methodology uses a non-expensive CuO Nano particles and aniline/ammonia along with substituted benzamide as the key ligand in this strategy. Moreover, efforts to find best reaction conditions to access N-substituted benzamidines ligands were accomplished. A brief study on behavior of N-substituted benzamidines against cancer cell lines (in vivo) and DNA binding studies by UV-visible spectrophotometer and Viscosity measurements has also been carried out. A detail work on transition metal (Cu, Pt, Pd) complexation of amidine ligands covering their activities against cancer cell lines (in vitro), DNA binding studies by UV visible spectroscopy and viscosity measurement covers the major area of thesis. The discussion about behavior of world fatal disease HIV-1 (candidiasis & reverse transcriptase) are also the part of thesis.