The Tradition of Innovation in Islamic Civilization: An Exclusive Study of Early Ages of Islam

اسلامی تہذیب میں تازہ کاری کی روایت: قرون اولی کا اختصاصی مطالعہ Islamic civilization was founded by the Holy Prophet (May blessings of Allah and peace be upon him) right from the beginning of Islam. Each civilization and every culture are deeply affected by the concurrent cultures and civilizations and it used to adopt and borrow many things from other civilizations. Similarly, Islamic civilization and culture borrowed many aspects from other prevailing civilizations. With the passing day, these intercultural relations and exchanges became the part and parcel of the Islamic civilization. Such communications, and they have marked all epochs in Islamic history, occur in greatly diverse ways. The Holy Prophet also approved some traditions in this regard and the four Caliphs adopted many customs too. This reflects the adoption and concluding from other civilizations is not prohibited in every case, but this adoption must not be against Islamic teachings. Now a days, the entire world has become a worldwide town because of internet and technological developments. It is relatively obvious that Muslims are adopting many things from western civilization and culture without knowing its legitimacy or illegitimacy. Resultantly, these activities apparently become the chunk of Islamic civilization. This investigation seeks guidance from golden period of Islam i.e. Early centuries of Islam and describes its validity or voidness. In this article, these experiences of Islamic civilization and culture in adopting and concluding from other civilizations and cultures have been conferred and their principles and opinion of the prominent scholars, in this context, been talked about in the light of Islamic teachings. This study will promulgate awareness about the tradition of innovation in Islamic civilization and will provide guidance to the new researchers about this topic.  

Immunoregulatory Effects of Indoleamine 2, 3-Dioxygenase in Primary Biliary Cirrhosis & Hepatitis C Virus-Induced Liver Cirrhosis

Indoleamine 2, 3-dioxygenase (IDO) is an enzyme which is involved in the degradation of L-tryptophan through kynurennine pathway. IDO induced immunosupression can be clinically beneficial for autoimmune diseases. Primary biliary cirrhosis is well defined by autoimmune lesion of intrahepatic bile duct epithelial cells. There is evidence that impaired IDO level contributes to the development of autoimmunity in PBC. Our aim was to assess the expression of IDO in our cell culture model and in PBC patients. Tryptophan metabolites are available and could potentially demonstrate utility in PBC. The current study establishes, for the first time, the expression of IDO in the H69 cell line and increase rate of conversion of tryptophan to kynurenine in patients with PBC. Furthermore, clinical biopsies from PBC patients demonstrated that the expression of IDO was observed not only in cholangiocytes as described earlier but also in hepatocytes. In the presence of TGF-β impaired IDO activity might contribute in the progression of disease scenario. The use of tryptophan metabolites could enhance the effects of IDO and compensate for the lack of efficiency of existing immunotherapeutic strategies. The positive effect of tryptophan metabolites on Human CD4+ T cells to induce polarization toward T-reg phenotype may render a prospective means to ameliorate the consequence of immunotherapy for the management of PBC. In this study we analyzed that the immunomodulatory enzyme IDO activity providing new insight into the pathogenesis of PBC. IDO-mediated immunosupression through tryptophan metabolites may be used against the progression of PBC. Hepatitis C virus (HCV) has infected more than 12 million Pakistani people. Our aim was to assess the expression and enzymatic activity of IDO in HCV patients. We observed high expression of IDO in HCV induced liver cirrhotic patients. IDO was significantly higher in the serum samples of HCV infected patients as compare to the control. It suggest that IDO may involved in the immunosuppression and possibly contribute to progression of HCV infection. Our findings advocated that the HCV patients with over expression of IDO might have poor prognosis, and IDO may become a newly useful marker for HCV induced liver cirrhosis. Thus, blocking IDO might provide new strategies as an adjuvant therapy intervention for HCV. The modeling of the biological regulatory networks (BRNs) using of Rene Thomas Formalism, we observed the critical role of TGF-β and IFN-γ in the suppression and induction of IDO. We observe two types of steady states behaviors in the state graph. The cycle shows the homeostasis of IDO and TGF-β while IFN-γ is inactive (silent). The stable state shows the high expression levels of IFN-γ and IDO while TGF-β is silent. There is a divergence from the cycle towards the stable states and it is observed that this divergence occurs when IFN-γ has expression levels. In cancers condition if we induce TGF-β which is negative regulator of IDO can create the homeostasis. Otherwise the expression of IDO can be inhibited by 1-MT. In case of autoimmune diseases if we inhibit the TGF-β the induction of IDO may produce homeostasis. Tryptophan downstream metabolites can also beneficial in this regard. Key words: IDO, PBC, HCV, IFN-γ, TGF-β, 1-MT, H69, Tryptophan metabolites, BRNs