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کلیات قدسی کا فکری و فنی جائزہ

Thesis Info

Author

ارشد محمود

Supervisor

محمود الرحمن

Institute

Allama Iqbal Open University

Institute Type

Public

City

Islamabad

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Page

169 ص

Subject

Other Literature

Language

Urdu

Other

Call No: 891.4391 ارک; Publisher: علامہ اقبال اوپن یونیورسٹی،

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676714801878

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ڈینگی مکائو مہم میں معاشرے کا کردار

ڈینگی مکاؤ مہم میں معاشرے کا کردار
ڈینگی بخار ہے جو چند ماہ سے پاکستان کے عوام کے لیے خوف کی علامت بنا ہوا ہے۔ یہ بخار 1775 میں افریقہ، شمالی امریکہ اور ایشیاء میں پراسرار طور پر نمودار ہوا، اس بخار کا سبب مادہ مچھر ہوتی ہے جو کاٹتی ہے تو بخار ہو جاتاہے۔ اس بخار کے پیراسائیٹس کو پلازموڈیم کہتے ہیں۔ یہ مادہ مچھر ایک اعلیٰ ترین نسل سے منسوب کی جاتی ہے جو گندے پانی وغیرہ کو پسندنہیں کرتی بلکہ خوشنما سرسبز پھولوں ، پھلوں والے پودوں اور درختوں پرڈیرہ جماتی ہے۔
ڈینگی بخار ایک مرض ہے، جس طرح دیگر امراض سے انسان کو واسطہ پڑتا ہے اسی طرح یہ مرض بھی اپنے خونخوار پنجوں میں جکڑنے کی بھر پور کوشش کرتا ہے۔ لیکن کوئی مرض ایسا نہیں ہے کہ جس کا علاج موجود نہ ہو۔ حدیث نبوی صلی اللہ علیہ و آلہٖ وسلمہے کہ کوئی مرض ایسانہیں ہے جس کا علاج نہ ہو، یعنی تمام مرض علاج سے ختم ہوجاتے ہیں۔ جب ایک ذی شعور انسان اس قسم کے حوالہ جات اپنے دماغ کے آنگن میں رکھتا ہے تو وہ ان عوارضات سے کبھی متاثر نہیں ہوتا وہ علاج کرتا ہے اور مسلمان ہونے کے ناطے بالخصوص اور انسان ہونے کے ناطے بالعموم شفاء من جانب اللہ کا تصور چاہتا ہے۔ اپنے اس اعتقاد کی بدولت کہ موت کا ایک دن مقرر ہے وہ اس بخار کے خوف کو اپنے نہاںخانۂ دل میں کوئی جگہ نہیں دیتا۔ اس بخار کے خاتمے میں اس قسم کے اعتقادات اور تصورات بڑی اہمیت کے حامل گردانے جاتے ہیں۔ اور یوں نفسیاتی طور پر اس سے متاثر مریض صحت یاب ہونا شروع ہو جا تا ہے۔
ڈینگی بخار کے خاتمے کے لیے معاشرتی طور پر ایک اہم رول ادا کرنے کی ضرورت ہے۔ واعظ ممبر رسول صلی...

An Appraisal of the Degree of School Effectiveness among Secondary Schools of Zamfara State, Nigeria

This study was conducted purposely to assess the degree of school effectiveness among public secondary schools of Zamfara State, Nigeria. In order to achieve this fundamental objective, one research question was formulated. A descriptive survey research design was adopted in the study. Population of the study comprised the entire 2361 classroom teachers deployed in the 158 public secondary schools of Zamfara State-Nigeria. From the population of the study, a sample size of 266 teachers was extracted using a ‘Multistage Random Sampling Technique’. A semi-structured questionnaire developed by Lezzote and Snyder (2011) on a five Likert type scale instrument with 21 items was employed as an instrument for data collection. The instrument composite reliability was computed using Cronbach’s alpha method and obtained the value of .949. All data covered in the study were collected through a field survey approach. Analytically, the current study discovered that, the degree of school effectiveness was at a high extent with mean score (M=3.68, SD=0.15). Based on this finding, the paper recommends that, stakeholders in educational sector comprising government’s ministries, departments and agencies, policymakers, secondary schools’ principals, instructional teachers as well as the learners and their parents/guardians should reciprocally work together in the process of appropriate perpetration and advancement of effective school system and its practices.

Bridging Mutational and Genomic Approaches for the Development of Novel Wheat Germplasm

In the present study, chemical mutagenesis was used to induce mutations in the wheat variety NN-Gandum-1 while gamma rays (γ rays) were used to induce mutations in Punjab-11 (Pb-11). The aim of mutagenesis was to improve resistance to the disease as well as to study function of genes conferring resistance to the disease. A total of 3,634 M5 mutant lines of NN-1 and 3,600 M5 mutant lines of Pb-11, 3,533 M6 lines mutant of NN-1 and 3,483 M6 mutant lines of Pb-11 and 3,502 M7 mutant lines of NN1 and 3,453 M7 mutant lines of Pb-11 were produced and characterized for days to heading (DH), plant height (PH), spike length (SL), tillers per plant (TPP), and resistance to leaf rust (LR) and yellow rust (YR). Across all the measured traits of three mutant generations, ranges of phenotypic values among the mutant lines were significantly larger than the corresponding values of wild type of both populations (0.57–12.52 for NN-1 and 0.62–11.5 standard deviations for Pb-11). Significant correlations of the traits between mutant generations confirmed the genetic basis for these traits. A subset of 239 M7 lines (17 NN-1, 222 Pb-11) were selected for their resistance to LR and YR. These lines also showed phenotypic variations for PH (12 NN-1, 137 Pb-11), DTH (9 NN-1, 14 Pb-11), TPP (6 NN-1, 52 Pb-11) and SL (12 NN-1, 81 Pb-11). For all these traits, mutant lines showed significant improvements as compared to the corresponding wild type. Cumulatively, Pb-11 mutant population exhibited more mutants (26.18%) than the EMS-treated NN-1 population (22.76%), owing to various genetic backgrounds, type of mutagen used and environmental conditions. In the M4 generation, a total of 11 M4 lines (nine absolute resistant and two highly susceptible) and one wild type were selected for NGS-based exome capture assay. A total of 104,779 SNPs were identified that were randomly distributed throughout the wheat sub genomes (A, B and D). Induced mutations in intronic sequences predominated. The highest total number of SNPs detected in this assay were mapped to chr.2B (14,273 SNPs), which contains the highest number of targeted base pairs in the assay. The average mutation density across all regions interrogated was estimated to be one mutation per 20.91 Mb. The highest mutation frequency was found in chr.2D (1/11.7 kb) and the lowest in chr.7D (1/353.4 kb). Out of the detected mutations, 101 SNPs were filtered using analysis criteria aimed to enrich for mutations that may affect gene function. Out of these, one putative SNP detected in xv Lr21 were selected for further analysis. The SNP identified in chimeric allele (Lr21) of a resistant mutant (N1-252) was located in a NBS domain of chr.1BS at 3.4 Mb position. These lines were again screened for resistant to the rust diseases along with their yield response at multiple locations for three consecutive crop years (2014-2016). In these trials, PGMB-15-30 was found the most resistant among all the mutants and showed higher grain yield potential compared to the wild type NN-Gandum-1, Morocco and local variety Galaxy13. In the national wheat disease screening nursery (NWDSN) trials, PGMB-15-30 demonstrated high resistance to LR and YR in three provinces of Pakistan during 2015-2016. Through computational analysis, it was demonstrated that the identified SNP causes a substitution of glutamic acid with alanine, resulting in a predicted altered protein structure. This mutation, therefore, is a candidate for contributing towards resistance phenotype in the mutant line. The newly developed wheat mutant resources can contribute novel alleles which can be used in developing new wheat cultivars as well as in getting insights into various biological circuits of different complex traits in wheat.