مسیحى دینیات اور بىن المذاہب تعلقات

Christianity in itself is a reformative offshoot of Judaism rather than a separate faith. The massage of Jesus Christ was directed at Jews and Jew formed the core of his early follower. In his early stage he was respected, honored and welcomed by his jew community. But as soon as he projected the universalism of Torah (Pentateuch) and declared Judaism as Inclusive religion the community fell in hostility toward him and  led him to crucify. In his early theology he gave the message of love, respect and tolerance to the light of a candle in room. The New Testament and it satellite portions unveil his and of his early followers teachings and their theological trend and behavior towards other nations and faiths. In this article the above mentioned teachings and theological policy of Jesus Christ and Saint Paul, an immediate stream him of Christianity has been abstracted from New Testament. It may help today’s Christianity to revise it religious teachings toward Islam and blasphemous behavior other religions and hence minimize the political tensions throughout the world.   

Design, Synthesis, Characterization and Anti-Inflammatory Studies of Oxa and Thiazole Scaffolds

Inflammatory diseases are associated with a number of ailments; these disorders could be life threatening like hepatitis, cancer, trauma injury while some decreases the quality of life such as rheumatism, arthritis, tuberculosis etc. Oxa and thiazoles, having unparalleled share in pharmacological activity of especially anti-inflammatory, have arisen as superb templates in drug discovery. Their unique attributes have instigated synthetic chemists to access their innovative analogues by efficient and viable strategies. Insightful insertion of other heterocyclic cores, bicyclic rings and other active functionalities at appropriate sites has greatly enhanced their diversified bioactivities. This research endeavor is made to synthesize some novel anti-inflammatory agents based on oxa/thiazole via green protocol. Hence synthesis of new derivatives of oxa and thiazoles by novel routes focusing green strategy such as DES mediated preparation were carried out by adopting Hantzsch approach. For this purpose, ketones containing simple alkyl to pretentious alkyl functionalities such as tetrahydrocarbazoles and aryl moieties like phenyl and coumarin were used. Besides this, novel amide and thioamide analogues were also synthesized by functionalizing established bioactive heterocycles at their N position and the second step is annulation of these analogous with a series of bioactive ketones. A series of novel oxa and thiazoles each comprising twenty one compounds were synthesized. All new molecules were screened for in vitro anti-inflammatory potential by HRBC membrane stabilization method. Precursors were also subjected to antiinflammatory screening and only those were employed for the synthesis of oxazole and thiazoles which were found comparatively potent. N N NH 2 X R 1 O CH3 N N X R 1 N H X N R 1 N Oxa/ thiazoles N H R H X 2N N R H X 2N Green / Conv. Precursors Characterization of all of the innovative derivatives was done by analytical techniques like FTIR, 1HNMR and MS and CHNS analyser. Compounds 110, 111, 113d, 113b, 113g, 114a, 114b, 114c, 114f, 115b, 115e, 115f, 116d, 117b, 117c, 118a, 118b were found to possess best anti-inflammatory activity.