سید صدیق حسن
سخت افسوس ہے ۶؍ ستمبر کویوپی گورنمنٹ کے سب سے زیادہ سنیئر آئی سی ایس، ممبرریونیو بورڈ سیدصدیق حسن صاحب نے اچانک داعیِ اجل کولبیک کہا اور اس دنیا سے رخصت ہوگئے۔انتقال سے صرف پانچ روز پہلے یعنی یکم ستمبر کو عصر کی نماز کے بعد دارالعلوم ندوۃ العلماء لکھنؤ کی مجلسِ انتظامیہ کاجلسہ تھا، مرحوم سے وہاں ملاقات ہوئی،حسب عادت بڑے تپاک اور گرم جوشی سے ملے۔ جلسہ کے اختتام پر ہم سب کے ساتھ مسجد ندوہ میں مغرب کی نماز پڑھی، باہر نکلے توراقم الحروف اوردوسرے حضرات کے ساتھ دس پندرہ منٹ بات چیت کرتے رہے اور پھر مولانا عبدالماجدصاحب دریابادی کواپنے ساتھ لے کر کارمیں بیٹھ کر رخصت ہوگئے۔ اس وقت دیکھنے میں کافی تندرست اور ہشاش بشاش تھے اوراس بات کا وہم وگمان بھی نہیں ہوسکتا تھا کہ بس اب عالمِ آب وگِل میں پانچ دن کے مہمان ہیں۔ پاکستان میں ایک قریبی عزیز کاانتقال ہوگیاتھا، اُن کی تعزیت کرنے کی غرض سے اپنی بیوی اور بیٹی کے ساتھ لاہور جارہے تھے ،امرتسر پہنچ کر کسٹم وغیرہ کے مراحل سے گزرنے کے لیے ایک متعلق افسر کی میز کے سامنے جاکر کھڑے ہوئے اور جیب سے پاسپورٹ نکال کرافسر مذکور کی طرف بڑھارہے تھے کہ وقتِ موعود آپہنچا ،یک بیک دل کی حرکت بندہوگئی اور دھڑام سے زمین پر گر پڑے ، لوگوں نے دیکھا تومرغِ روح قفسِ عنصری سے پرواز کر چکا تھا۔ ’’انا ﷲ وانا الیہ راجعون ‘‘۔
مرحوم کی شخصیت عجیب وغریب کمالات واوصاف کی جامع تھی،حکومت کے اعلیٰ افسر ہونے کی حیثیت سے نہایت لائق وقابل، بڑے نیک نام اور حکومت اور پبلک دونوں کی نگاہ میں معتمد اورقابلِ احترام تھے۔ ہرمعاملہ میں سرکاری ہو یا غیرسرکاری اُن کی ایمان داری اوردیانت پرسب کاایمان تھا۔ ضرورت مندوں کے ساتھ ہمدردی وغمگساری اور عملاًان کی امداد واعانت...
Islam is religion of humanity that wants us to behave good to others and has nothing to negate the rights of others. Minorities also have their legal rights in a welfare society, which makes itself an examplary society. Islam is a religion that negates violence. The rights of minorities can be traced in islamic society by many saying of Holy Prophet ﷺ. Holy Prophet ﷺ always advised muslims to treat the minorities kindly. Whatever the deligation of minorities came, Prophet ﷺ hosted himself. In the same way, when a deligation came from Najran, Prophet ﷺ not only hosted but allowed them to worship in Masjid al Nabi according to their own religion. In the light of ordinance of Prophet ﷺ, even fourteen centuries have passed but minorities are being given their rights. According to the law and order of a welfare state, minorities must be given their rights. In this article, the rights of minorities in a welfare state are tried to discuss.
Research work, presented in the dissertation, described clinical and molecular analysis of twenty one families (A-U) segregating various types of skeletal deformities. Thirteen of these families (A-M) showed clinical features of dysostosis while eight others (N-U) represent condition of osteochondrodysplasia. After characterizing clinical spectrum in each family, genetic investigation, using various techniques, was conducted to search for the disease genes carrying the responsible sequence variants. Four families (A-D) presented features of split-hand/split-foot malformation (SHFM). Genotyping followed by Sanger sequencing or whole genome sequencing revealed four novel disease causing sequence variants in four different genes including WNT10B, DLX5, DLX6, and TP63. Five families (E-I) showed segregation of polydactyly in autosomal recessive pattern. In two of these families, E and F, whole genome and/or Sanger sequencing revealed two novel sequence variants (p.Arg113*, p.Leu506Glu) in the GLI1. This was the first report of involvement of GLI1 in causing skeletal disorder. In family G, SNPs based genotyping mapped the disease locus at chromosome 4p16.2-4p16.1 and 8q21.3- 8q21.3. However, exome sequencing failed to identify the variant segregating with the disease within the family. In another family (I), a novel locus for Polydactyly was mapped on chromosome 13q13.3–q21.2. Two families J and K presented features of isolated and syndromic form of brachydactyly, respectively. Direct Sanger sequencing revealed a deletion variant (p.Leu176Argfs*17) in the GDF5 in family J and a missense variant (p.Arg921Gln) in the TRPS1 in family K. Variable phenotypes of camptodactyly were found in two families (L and M). Genotyping using microsatellite markers established linkage in both the families at 17p13.3. However, sequence analysis revealed a novel homozygous indel variant (c.252_270delinsGCA; p.Phe85Glufs*108) only in family M. Eight families, presented here, showed various types of osteochondrodysplasia. Three of these families (N-P), segregated Bardet-Biedle Syndrome (BBS) in autosomal recessive pattern. The families N, O and P were mapped to BBS6 (20p12.2), BBS7 (4q27), and BBS8 (14q31.3), respectively. Sequence analysis revealed three novel homozygous mutations including p.Ala96Val in BBS6 in family N, p.Ala194del in BBS7 in family O, and p.Gln449His in TTC8 in family P. Two families Q and R showed frontonasal dysplasia segregating in autosomal recessive manner. SNPs micro-array followed by whole exome and Sanger sequencing revealed two novel disease causing variants including a non-sense (p.Gln202*) in the ALX3 in family Q and splice site (c.661-1G>C) in the ALX1 in family R. Two families, S and T, showed disproportionate short stature segregating in autosomal recessive pattern. Haplotype analysis established linkage of family S to the gene BMPR1B on chromosome 4q22.3. Sanger sequencing revealed a disease causing missense variant (p.Met397Arg) in the BMPR1B in the family. Microsatellite-based genotyping established linkage in the family T on chromosome 16q24.3. Sequence analysis detected a disease causing variant (p.Glu121Argfs*37) in the GALNS gene in family T. In family U, three affected individuals showed Waardenburg anophthalmia syndrome (Anophthalmia-syndactyly). SNPs based homozygosity mapping followed by Sanger sequencing revealed a homozygous missense variant (p.Cys271Tyr) in the SMOC1 gene in the family.