Intake of Anti-Epileptic Drugs and their Influences on Sexual Dysfunctions

Epilepsy which is also called seizures disorder is an uncontrolled action of the central nervous system. It is not a single disease but a set of neurological disorders. Actually in this situation, the brain does not receive a precise signal and as a result an abnormal condition is produced that is usually involuntary in action. In this review, we aimed to focus on the relationship of anti-epileptic drugs with sexual dysfunction and adaptation of better remedies that improve a patient’s family life. Sexual dysfunction is a common comorbidity in people with epilepsy which badly affects their quality of life. Sexual dysfunction is caused by different factors like psychiatric problems, anti-epileptic drugs (AEDs) and social factors etc. Sexual dysfunctions include ejaculatory failure, lessen libido, penile erection in men and irregular menstrual cycle in women. Common drugs such as Topiramate, Gabapentin (GBP), Valproate (VA), Carbamazepine (CBZ), Olanzapine (OL) and Risperidone (RTG) that are in practice to treat epilepsy usually produced adverse effect on sexual dysfunction. Even though a lot of studies have been carried out to control sexual dysfunction in epilepsy’s patient, but still research is going on. Medicine such as Cyproheptadine, Mianserin, Buspirone, Yohimbine were found better to treat epilepsy with minimum side effects of sexual dysfunction. Moreover, it is also seen that certain vasodilators,  folate , and vitamin supplements are effective in improving the quality of life.

On alleged defects in black-hole mathematics: black hole existence controversies hinging on solution of field equation

The black hole existence and formation have been an unsettled debate, from inception, inviting the attention to look into the matter closely. Despite myriads of evidences for existence, the mathematical possibility of black hole-from Schwarzschild anticipation till the completion of physical structure- continues to be contested among theorists. Various aspects of mathematics involved in theoretical creation of black hole are exposed to question. Also, black holes' overwhelmingly capricious physical nature adds to curiosity of opponents to challenge the underlying theory as doubtful because of its being source of astounding outcomes. In this investigation we aimed at highlighting the conceptual elements in mathematics of black holes that breed the controversy. The reasons that permit the divided view over single physical entity are required to be pointed out in order to bring betterment into the way we run our mathematical investigation. The reasoning supports possibility of creation and existence of black holes along with physical and experimental evidences, would not be undermined here in order to restrict the investigation at finding the prime responsible elements in mathematical track that have potential to bring forth living disputes. The mathematical assumptions that serve as authentication to employ certain mathematical procedure to discuss formation of black holes and the role of mathematics in forming its intuition will be investigated conceptually and possibly philosophically, to reveal the anomalies: yet many other schemes and arguments may exist. This discussion is not aimed at disapproving the existence of black hole but the basic purpose is to reveal how Black Hole's mathematics remains controversial despite assumed evidence for existence