سیمیں کے افسانوں میں سماجی و تہذیبی عکس
انعم زاہد
بڑے ادیب کی پہچان اس کی تخلیقی انفرادیت ہوتی ہے اور یہ ہی انفرادیت اسے دوسرے ادیبوں سے تشخص عطاء کرتی ہے اس کے فن کی خوبیاں اس کے بعد آ تی ہیں بلاشبہ سیمیں کرن موجودہ دور کے ادیبوں میں ایک جانا پہچانا نام ہیں آ پ اردو ادب میں فکشن نگاری ،تبصرہ نگاری ،اور کالمز لکھنے میں پیش پیش ہیں ۔۔۔۔۔
خالدہ حسین نے کہا تھا کہانی لکھنے کا عمل میرے لیے اپنے وجود سے رشتہ قائم رکھنے کی ایک کوشش کا نام ہے تو جب میں اپنا وجود خطرے میں محسوس کرتی ہوں تو خود کو لکھنے پر مجبور پاتی ہوں ۔۔۔۔۔! بلکل یہ ہی رشتہ سیمیں کا کہانیوں کے ساتھ ہے ان کے نزدیک ادب زندگی کے حبس اور گھٹن میں ایک تازہ ہوا کا جھونکا ہے ادب ایک ایسی کھڑکی ہے جو اندر باہر کھلتی ہے وہ کہتی ہیں کہ میں کہانی کب لکھتی ہوں وہ مجھے خود گلے آ ملتی ہے کسی سہیلی کی طرح ۔۔۔۔۔۔کسی کردار کی صورت ۔۔۔۔اور میرے کان میں سرگوشی کرتی ہے کہ مجھے پڑھو مجھے لکھو۔۔۔۔۔۔! اب تک مصنفہ کے 3 افسانوی مجموعے، 2 ناول اورمختلف سماجی و سیاسی موضوعات پر کالمز تبصرے چھپ چکے ہیں آ پ نے ہر صنف ادب میں طبع آزمائی کی ہے اور کامیاب ہوئی ہیں۔
ادیب ،ادب ،اور سماج کا آپس میں گہرا تعلق ہوتا ہےایک ادیب بہت حساس طبیعت کا مالک ہوتا ہے معاشرے کے اندر بگاڑ پیدا کرنے والے عوامل اسے ہمیشہ بے چین رکھتے ہیں اور لکھنے پر آ مادہ کرتے ہیں سیمیں کرن بار بار سنی سنائی کہانیاں پیش نہیں کر تی ہیں ان کے ہاں نمایاں ترین موضوعات میں...
At the time of arrival of Muslim community in Sub-Continent Region and due to their settlement in the region Arabic Language has been prevailed and such as the system of its publication and learning has been commenced. Because the directives of Islam and laws are in the Arabic Language as per Quran & Sunna so that it is necessary to learn the Arabic language for the awareness of Islamic directions. So that to achieve the knowledge of Sharia inclu-ding the expertise the peoples of Sub-continent has been achieved the expertise of Arabic language, literature, knowl-edge Ilmul Saraf al-khawa, knowledge of al-ishtiaq & Ilmul Balaghta etc. Moreover it is clarify that Scholar of religious have shown their expertise so that the scholar of Arab have been convinced their expertise. The basic point of service in Arabic Language of Scholars of Sub-Continent that they do not served only to enhance the language but the cause of service was to serve themselves on religious matters and represents themselves on work hard and tried themselves to achieve the better performance of identification of Islam. A positive result and effects have been achieved as a sun shining of Islam is remaining and its waves are enhancing all around the world such as the sun shining of Islam is remained in Arab world such as the publication of literature is also remaining in the Sub-Continent region in the actual shape and saved. Because the Islam will remain till the day of judg-ment and its representatives/workers will born till the date such as the scholars of literatures will also born and they will save the knowledge of Arabic. They will alive till the Day of Judgment.
Liver is a principal organ that preserves the homeostasis of human body and performs many other functions including; detoxification of drugs, storing glycogen, regulating cholesterol and metabolism of urea. Liver injury induced by drugs is still a critical obstacle in the successful development of medicines. Acetaminophen (APAP) is an extensively consumed pain killer and is also the main cause of Drug Induced Liver Injury (DILI). An established biomarker for analyzing liver injury at molecular level is Cytochrome-P450 2E1 (CYP2E1) enzyme, mostly associated with the acetaminophen hepatotoxicity. Thus, a safer more reliable and economical way to deal with DILI is to determine an alternative use of the approved drugs. Binding of adrenergic ligands with their particular receptors is prevented by alpha-adrenergic blockers and is used in treating benign prostatic hyperplasia, cardiovascular disorders and erectile dysfunction. In this current proposal we have investigated whether terazosin (TER), an alpha adrenergic blocker, is effective as a hepatoprotective agent in an acetaminophen induced acute liver injury induced animal model. White New Zealand rabbits were used as animal models and were given an oral dose of acetaminophen to induce acute liver injury. It was observed that the Adenosine triphosphate (ALT) and Alkaline phosphatase (ALP) levels were much reduced by TER. ALT results showed statistical significance when compared with APAP alone. The serum ferritin level result was found to be decreased following the APAP intake. Lipid profile was much improved by TER as it decreased the level of Triglycerides (TG), Total Cholesterol (TC), Total Lipids (TL) and Low Density Lipoproteins (LDL) and increased the level of High Density Lipoproteins (HDL). TG level was statistically significant when comparing CON with both APAP and TER. Urea and creatinine level was also reduced indicating that TER acts as renal efficient agent. As CYP2E1 is upregulated during liver injury, it was observed that TER downregulated the expression level of CYP2E1. Hence, it can be stated that TER is not only safer for arterial hypertension but it is safe for human consumption. TER showed prevention of acute liver injury that was caused by acetaminophen, thus further studies can strengthen its alternative use in hepatoprotection.