مجھے کتنی سہولت ہے۔۔۔ازہر ندیم
مجھے جب زندگی کے حسن کا ادراک کرنا ہو
مجھے جب آسماں کی وسعتوں سے بات کرنی ہو
مجھے پھولوں ستاروں سے کوٸ منظر سجانا ہو
مجھے خوشبو سے مہکے موسموں کو گھر بلانا ہو
مجھے رنگوں کی دلکش وادیوں کی سیر کرنی ہو
مجھے آواز کے جادو میں جب بھی ڈوب جانا ہو
مجھے کتنی سہولت ہے
میں ان پھیلی ہواٶں میں بس اک پیغام لکھتا ہوں
میں ان خالی فضاٶں میں تمہارا نام لکھتا ہوں
مجھے ہر سو جمالِ خواب کی برسات ملتی ہے
تمہاری یاد سے مجھ کو ، یہ کاٸنات ملتی ہے
مجھے کتنی سہولت ہے
After the Incident of 9/11 Pakistan decided to become the ally of America and play an important role in fighting terrorism on both domestic and global fronts. This war has destroyed the peace of Pakistan and has affected the Economy of Pakistan desperately. The decision of Pakistani government to fight the so called war on terror with America only to get the financial and political support of America was clearly against the teachings of Islam. However, Pakistan did receive financial benefits in this war. The important development in the wake of 9/11 is that Pakistan became the biggest beneficiary of US economic aid in the South Asian region. Despite the GDP growth, foreign aid, foreign investment, better record of foreign exchange reserve, worker remittances and debt rescheduling Pakistan’s economy did not show the desired results. The change in the Pakistan’s economy during this period is not sustainable in economic term. Due to the war on terror law and order situation has become worst. At present Pakistan is facing most unique, difficult and gruesome faces of terrorism. In this situation fiscal policy in Islamic perspective is prerequisite for the peace and economic development of Pakistan.
Generally speaking, many drugs acquire modified toxicological and pharmacological properties when they are in the form of metal complexes. The metals and their compounds have been used for medical applications throughout history. It was not until the 20th century the metal complexes began to be screened systematically for medicinal properties and the concept gained huge enhancement after the approval of Cisplatin, platinum containing anticancer drug. Working on metal complexes of already approved drugs can substantially reduce the time and money spent in clinical development. Seven Series of Copper, Zinc, Iron, Antimony, tri- and diorganotin (IV) metal complexes were synthesized by using stoichiometric amounts of various drugs. Drugs were selected from various categories in order to study their effect on the biological assay. Drugs used were Nimesulide, Ribavirin, Piracetam, Tizanidine, Cimetidine, Gliclazide, Acyclovir and Ceftriaxone. Taking in account the most commonly used NSAIDs, antibiotics and antivirals groups but the selection made was, due to the availability of the drugs and their structure’s that allowed metal coordination. FT-IR, 1H and 13C NMR analysis were used for the structural assignment of the synthesized complexes. The results obtained from different analytical techniques confirmed the formation of the metal complexes. The purity of the synthesized complexes was justified by elemental analysis. All the synthesized complexes were screened for antibacterial and antifungal analysis, against medically important bacteria and fungi. Overall some of the synthesized metal complexes showed higher activity than the standard. The Toxicological activities of the synthesized complexes were studied through MTT and FRET Melting assay. In general, the copper and zinc complexes showed remarkable activity compared to organotin, iron and antimony complexes. The results of the activities of the synthesized complexes suggested that these synthesized metal complexes may be used in chemotherapy as well as bactericidal and fungicidal agents in future.