28. Al-Qasas/The Narratives
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
28:01
a. Ta. Sin. Mim.
28:02
a. These are the Messages of the Clear Book - The Divine Qur’an.
28:03
a. WE are going to recount to you some of the narratives of Moses and Pharaoh truthfully, for a people who believe.
28:04
a. Indeed, Pharaoh exalted himself in the land of Egypt, and
b. divided its citizens into different ethnic and social factions,
c. seeking to oppress one faction among them - Descendants of Jacob – and depriving them of all human rights and civil liberties,
d. and, slaughtering their baby-boys at birth, while sparing their women/baby-girls.
e. He - Pharaoh - was truly of the oppressors and tyrants.
28:05
a. However, WE wanted to empower those very people who were being oppressed in the land
of Egypt – Descendants of Jacob, and
b. to make them the leaders and to make them the inheritors.
28:06
a. And to empower them in the land by giving them political power and religious authority,
b. and to show Pharaoh and Haman and their armies - through them - the very thing that they had dreaded - and trying to prevent.
28:07
a. And so when Moses was born, WE inspired Moses’ mother by saying that:
b. ‘Keep breast feeding him as usual, but when you fear for his life, then put him afloat into the River Nile,
c. and, once you have done so, then do not fear and do not grieve for he will be saved.
d. Surely WE...
The issue of the source and origin of Sufism in Islam is a complex one. A number of scholars, since the latter half of the nineteenth century have put forward conflicting claims. Earlier Orientalists thought that a Sufism developed from a single source while the latter scholars think a number of different sources should be considered as origin of Sufism. Both groups agree, however, in maintaining that Sufism is an addition to Islam and did not originally belong to Islam. Different opinions have been presented regarding the true source of Sufism, for example, Persian, Indian, Christian, Jewish and Neo-Platonic philosophies. The present paper intends to refute these charges of external influences on Islamic Sufism and attempts to show that the real origin of Islamic Sufism lies nowhere but in the teachings of the Holy Qur’an, Sunnah of the Prophet (peace be upon him) and lives of the blessed companions of the Prophet (peace be upon him).
The presented research work in this dissertation comprises of synthesis, characterization, antimicrobial, hemolytic and enzyme inhibition studies of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches (scheme-1-11) were utilized to synthesize poly-functional compounds. In first scheme, twenty three 5-substituted-1,3,4-Oxadiazol-2-thiols were synthesized by converting multifarious organic acids consecutively into the corresponding esters and hydrazides. Further the intermolecular cyclization of various carbohydrazides with carbon disulfide and potassium hydroxide yielded subsequent 5- substituted-1,3,4-Oxadiazol-2-thiols. Moreover, the reaction of different 5- substituted-1,3,4-Oxadiazol-2-thiols (scheme-2 & 3) with electrophiles, 2-bromo-N- [4-(4-morpholinyl)phenyl]acetamide and 2-bromo-N-[2-(4-morpholinyl)phenyl] acetamide yielded thirteen, N-[4-(4-morpholinyl)phenyl]-2-[(5-aryl/aralkyl-1,3,4- Oxadiazol-2-yl)thio]acetamides and fourteen N-[2-(4-morpholinyl)phenyl]-2-[(5- aryl/aralkyl-1,3,4-oxadiazol-2-yl)thio]acetamides respectively in the presence of N,N- dimethylformamide and sodium hydride. Sixteen novel benzyl sulfides (scheme-4) bearing 1,3,4-oxadiazole moiety and sulfo- morpholine functionality were synthesized (bromomethyl)phenyl)sulfonyl)morpholine with by the different reaction of 4-(4- 5-substituted-1,3,4- Oxadiazole-2-thiols. Nucleophilic substitution reaction of free thiol group in 1,3,4- Oxadiazoles with 4-(2-chloroethyl)morpholine hydrochloride yielded thirteen, 4-[2- [[5-aryl/aralkyl-1,3,4-Oxadiazol-2-yl]thio]ethyl]morpholine derivatives (scheme-5) in the presence of acetone and potassium carbonate . A series of nineteen electrophiles (scheme-5), N-substituted-2-bromoacetamides was developed by the reaction of different substituted/unsubstituted aryl/aralkyl/alkyl amines with 2-bromoacetyl bromide by using DCM or basic aqueous medium as solvent. Seventy one (71) acetamides were synthesized by the reaction of 5-(2-chloro/3- chloro/4-chloro/4-nitrophenyl/phenyl)-1,3,4-Oxadiazol-2-thiols with different electrophiles by simple stirring in the presence of DMF solvent and NaH base at the room temperature. The structures of all the synthesized compounds were characterized by using IR, 1H- NMR and mass spectral data. In addition, 13C-NMR technique was also used in some cases to support the structural analysis. A rational mass fragmentation pattern of some of the compounds is also proposed. Some of the 1H-NMR, 13 C-NMR and EIMS spectra of synthesized compounds are also presented for the obvious perceptive of signals. The synthesized compounds were evaluated for antibacterial, antifungal, hemolytic and enzyme inhibition activities. Some of compounds were found to be active and showed interesting results in different studies declared above. The biological activity data in comparison of each scheme with the reference standard drugs is presented in biological activity section.