شب برات اور آتش بازی کی قبیح رسم
انسان کی ہمیشہ سے خواہش رہی ہے کہ کام تھوڑ ا کر نا پڑے اور اس کی مزدوری اور اُجرت زیادہ مل جائے۔ اللہ تعالیٰ نے بھی کچھ اوقات ایسے مقرر کیے ہیں کہ اس میں دین اسلام پر کار بند شخص تھوڑی سی عبادت کر کے ڈھیروں ثواب کما سکتے ہیں۔ ان اوقات میں لیلۃ القدر یعنی شب برات بھی ہے جو پندرہ شعبان المعظم کی رات ہے اور کروڑوں مسلمان اس رات میں شبِ بیدار ی کر کے اپنے پروردگار کے سامنے سر بسجدہ ہوتے ہیں اور اپنے گناہوں کی معافی کے طلبگار ہوتے ہیں۔ چنانچہ قرآن مجید میں ہے کہ:۔
’’حم قسم ہے کتاب مبین کی بیشک ہم نے اتارا ہے اسے ایک برکت والی رات میں بے شک ہم ڈر سنانے والے ہیں، اس رات ہرحکمت والا کا م بانٹ دیا جا تا ہے۔‘‘
تشریح! یہاں کتاب مبین سے مراد کلام اللہ یعنی قرآنِ مجید فرقانِ حمید ہے اگر چہ بعض مقامات پر اس سے مرادلوح محفوظ بھی ہے۔ نزولِ قرآن کی رات کی عظمت و فضیلت کو ظاہر کرنے لیے اللہ تعالیٰ نے قرآنِ مجید کی قسم ارشاد فرمائی۔ لیلۃ القدر برکتوں والی رات اس رات کے تعین میں مختلف اقوال ہیں لیکن عام طور پرد وقول زیادہ مشہور ہیں ایک تو یہ کہ اس سے مراد لیلۃ القدر ہے جو ماہ ِرمضان شریف میں آتی ہے۔ دوسرا قول یہ ہے کہ اس سے مراد شب ِبرات ہے جو شعبان المعظم کی پندرھویں رات ہے جیسا کہ تفسیر مظہری میں ہے۔ حضرت عکرمہصنے کہا کہ یہ پندرھویں شعبان کی رات ہے جس میں سال بھر کے امور لکھ دیئے جاتے ہیں جنہیں مرنا ہوتا ہے انہیں زندوں کی فہرست سے نکال دیا جاتا ہے پھر ان میں نہ زیادتی کی جاتی ہے نہ کمی۔
Peace has great importance both for the individual and the communal life. Wherever peace turned into unrest, the tendencies of social violence, mental sickness and insecurity start developing amongst the people. Peace and harmony were the hallmark of the reign of the 2nd caliph, Haḍrat ‘Umar. He gave the best governing mechanism to the people of Arab, when they were not fully aware of rules & regulation of government. Though the empire was wide spread, he exercised a great sort of command & control on it. He took the responsibility of providing his subjects their basic needs: Food, Shelter, Education, Peace and Justice. This was not only an ideal system of its time but became the role model for the modern welfare state. Peace and harmony is as important for a state as food & air are for life. Allāh has strongly emphasized in The Holy Qur’ān" on two things i. E., "Disharmony & hunger" which should be eliminated from a society. Haḍrat ‘Umer during his reign of 10 years presented Islām as a religion of peace & harmony, a religion, which respects humanity, peacefully resolves disagreements and curtails misuse of power. He himself possessed the qualities of peace & harmony to an utmost level, which were the traits of our Holy Prophet’s (ﷺ) personality. It is important to follow the Khilāphah of Haḍrat ‘Umar to bring peace & justice in the society.
This work is concerned with synthesis of multiresponsive smart copolymer hybrid microgels and polymer drug conjugates. Work can be divided in to two parts. In first part, we have synthesized both cationic and anionic hybrid microgels. Cationic pure NIsopropylacrylamide and vinyl imidazole copolymer, P(NIPAM-co-VI), microgels with different amount of vinyl imidazole were synthesized by free radical emulsion polymerization. Then, the hybrid microgels, P(NIPAM-co-VI)-Ag, was prepared and their thermal and pH dual responsive properties were studied. Thermogravimetric analysis were also carried out for the amount of metal content, and a maximum content 51.8% was obtained for P(NIPAM-co-VI)-3-Ag. The pH and thermos-responsive behavior was also analyzed for surface plasmon resonance using uv-visible spectroscopy. All the hybrid microgels could be stably dispersed in water at a pH range from 3.0 to 9.3, which is favorable to use p(NIPAM-co-VI)-Ag as a catalyst in the reduction reaction of p-nitrophenol. The highest reaction rate constant (kapp) value 4.49×10-3 sec-1 was observed for p(NIPAM-co-VI)-3-Ag at pH 2.95. Reaction rate was dependent on pH of the medium and the content of 1-VI in the copolymer microgels. We have also prepared anionic copolymer microgels based on thermal NIPAM and pH sensitive MAA. In-situ reduction method was used to prepare silver and gold hybrid microgels at two different pH’s. The surface charge involved in the change of particle size, was confirmed by calculating zeta potential values at different pH’s using dynamic light scattering. The prepared hybrid microgels were used as a catalyst for the reduction of p-nitrophenol to p-aminophenol. Our results shows that the p(NIPAM-co-MAA)s-Au catalysts are more efficient as compared to p(NIPAM-co-MAA)s-Ag. In the second part, we have synthesized a novel redox-responsive polymer–drug conjugate (PDC) based on hydrophilic diblock copolymer covalently bonded with paclitaxel (PTX) by a disulfide linker, and evaluated it for intracellular drug delivery. The well-defined hydrophilic diblock copolymer, PEG-b-PHEMA, was synthesized via atom transfer radical polymerization of 2-(trimethylsilyloxyl)ethyl methacrylate (HEMA-TMS), using PEG-Br as a macroinitiator and CuBr/PMDETA as the catalytic system, followed by selectively hydrolyzing the trimethylsilane group to hydroxyl groups. Utilizing the hydroxyl groups as an active reaction site, paclitaxel was covalently conjugated onto the backbone of the diblock copolymer, with a disulfide linker as a spacer to bridge the copolymer and PTX, and the loading content of paclitaxel was 18.4 wt%. Due to the different solubility of segments in the polymer–drug conjugate, the amphiphilic PEG-b-P(HEMA-PTX) could self-assemble into spherical micelles in aqueous solution, with hydrophobic PTX as core and hydrophilic PEG chains as shell. The in vitro cytotoxicity experimental results shows that the diblock copolymer is biocompatible, with no obvious cytotoxicity, whereas the PEG-b-P(HEMA-PTX) conjugate showed glutathione-dependent cytotoxicity with higher cellular proliferation inhibition against glutathione monoester pretreated HeLa cells than that of the nonpretreated HeLa cells. We are convinced that polymer–drug conjugates based on disulfide linkers will be a promising platform for targeted intracellular controlled drug delivery in cancer therapy.