Novel Bioactive Compound Production by Microbial Biota: Potential Antimicrobials Potential antimicrobials produced by microbial biota

Man is always trying to make his life easier and accomplished. He has faced mass destruction in history due to epidemics like small pox, malaria and plague. In order to combat diseases, exploration of man led him to search for causative agents and their control. A time reached when it was found that microbes are themselves a source of potent metabolites which have proved to be effective as drugs and medicines showing great antibiotic activity. It is necessary to find out new sources for potential new antimicrobial compounds. Several hundred important compounds have been isolated which have antibiotic activities and diverse chemical nature. But these compounds should have minimum toxicity to be useful clinically. Because of the increasing resistance of pathogens, there was a never ending desire and need to search for more. Bioactive Compounds have been extracted from microbes which are produced as secondary metabolites. Day by day, new compounds are being discovered giving a hope of golden future of drug industry. The current article emphasizes the importance and need to search for new bioactive compoundsto overcome infections caused by multiple drug resistant (MDR) and biofilm forming pathogens irrespective of the previously present knowledge. 

A Classifier for Isolated Complete Intersection Singularities of Modality ≤ 1

The aim of the present thesis is to study, develop and implement certain algorithms in order to find the type of singularities for isolated complete intersection singularities w.r.t contact equivalence of modality ≤ 1 defined over an algebraically closed field K. The new investigation is that we do not compute the normal form of a given singularity because this would be space and time consuming. We present a charac- terization of the different types of singularities in terms of certain invariants and use the characterization to identify the singularities. We describe our implementation in computer algebra system Singular. Therefore, we discuss three problems in this thesis. • Problem 1 deals with the classification of hypersurface singularities with respect to contact equivalence when the characteristic of the field p > 2 by using blowing up as a new tool. • Problem 2 studies the classification of simple complete intersection singularities in terms of certain invariants when the characteristic of the field p = 0. • Problem 3 includes to find the complete list of unimodular complete intersection space curve singularities and the characterization of these singularities in terms of certain invariants when the characteristic of the field p = 0