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Pharamaceutical Care Measure of Tuberculosis Among Internally Displaced Persons of North Waziristan Agency and the Adjacent Urban Areas of Kpk

Thesis Info

Author

Farman Ullah Khan

Supervisor

Tofeeq Ur-Rehman

Department

Deparment of Pharmacy, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Page

viii, 87 + aendices

Subject

Pharmacy

Language

English

Other

Call No: Diss / M. Phil / BIO / 4657

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676715942397

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مختلف اعضا ء کی دیت

حضرت ابو بکر بن محمد بن عمرو بن حزمؒ (م:120ھ)اپنے والد سے روایت کرتے ہیں کہ رسول اللہ ﷺ نے ان کو دیت کے بارےمیں تفصیلاً لکھا
"أَنَّ فِي النَّفْسِ مِائَةً مِنْ الْإِبِلِ وَفِي الْأَنْفِ إِذَا أُوعِيَ جَدْعًا مِائَةٌ مِنْ الْإِبِلِ وَفِي الْمَأْمُومَةِ ثُلُثُ الدِّيَةِ وَفِي الْجَائِفَةِ مِثْلُهَا وَفِي الْعَيْنِ خَمْسُونَ وَفِي الْيَدِ خَمْسُونَ وَفِي الرِّجْلِ خَمْسُونَ وَفِي كُلِّ أُصْبُعٍ مِمَّا هُنَالِكَ عَشْرٌ مِنْ الْإِبِلِ وَفِي السِّنِّ خَمْسٌ وَفِي الْمُوضِحَةِ خَمْسٌ۔"173
" جان کے بدلے میں سو اونٹ ہیں اور جب ناک مکمل کاٹ دی جائے تو سو اونٹ اور دماغ اور پیٹ کے زخم میں تہائی دیت ہے اور آنکھ کی دیت پچاس اونٹ اور ہاتھ اور پاؤں کی دیت میں پچاس اونٹ اور ہر انگلی میں اسی طرح دس اونٹ ہیں اور دانت اور موضحہ زخم میں پانچ پانچ اونٹ ہیں۔ "
حضرت ابو بکر بن محمد بن عمرو بن حزمؒ اپنے والد سے اور وہ اپنے دادا سے روایت کرتے ہیں کہ رسول اللہ ﷺ نے یمن کے باشندوں کے نام ایک خط لکھا ،جس کے الفاظ یہ تھے
" وَفِي الْأَنْفِ إِذَا أُوعِبَ جَدْعُهُ الدِّيَةُ وَفِي اللِّسَانِ الدِّيَةُ، وَفِي الشَّفَتَيْنِ الدِّيَةُ وَفِي الْبَيْضَتَيْنِ الدِّيَةُ، وَفِي الذَّكَرِ الدِّيَةُ وَفِي الصُّلْبِ الدِّيَةُ، وَفِي الْعَيْنَيْنِ الدِّيَةُ وَفِي الرِّجْلِ الْوَاحِدَةِ نِصْفُ الدِّيَةِ، وَفِي الْمَأْمُومَةِ ثُلُثُ الدِّيَةِ، وَفِي الْجَائِفَةِ ثُلُثُ الدِّيَةِ، وَفِي الْمُنَقِّلَةِ خَمْسَ عَشْرَةَ مِنَ الْإِبِلِ۔"174
"اگر کسی کی ناک پوری کاٹی جائے تو پورا خون بہا ہو گا۔ زبان کے کاٹے جانے پر بھی پوری دیت ہے۔ ہونٹوں پر بھی پوری دیت ہے۔ خصیوں پر بھی پوری دیت ہے ۔ آلہ تناسل پر بھی پوری دیت ہے ۔ پیٹھ کی ہڈی پر بھی پوری دیت ہے۔ آنکھوں پر بھی پوری دیت ہے ، ایک ٹانگ پر آدھی دیت ہے، آمہ (دماغ کا زخم)پرتہائی دیت ہے۔ زخمی کرنے پر بھی تہائی دیت ہے اور زخم سے...

استنباطِ احکام میں ضعیف حدیث کا مقام اور فقہاء کی آراء کا تجزیاتی مطالعہ Analytical study of the Status of hadith e Da’eef in the interpretation of rulings and the opinions of the jurists

There are two main sources of Islam, one is the Book of Allah and the other is the Sunnah and Sira of the Prophet (peace be upon him). The Qur'an is the final collection of 23 years of divine revelation revealed to the Holy Prophet (PBUH) whose literal and spiritual preservation was undertaken by Allah Almighty Himself. Therefore, the Qur'an is the only book in the world which has one letter, one action and one line in its original state just as it was revealed to the pure heart of the Holy Prophet (sws) and the Holy Prophet (sws). The Prophet (peace and blessings of Allaah be upon him) told the Sahaabah. That is why the greatest truth of Islam, the book is the living Qur'an. The second major basis of the reality of Islam is the pure Sira and Sunnah of the Prophet of Humanity, the Servant of the Universe. Like the Qur'an al-Hakim, every moment, every day and every angle of the life of the author of the Qur'an is in front of everyone like an open book with all its mysteries. Even in front of one's own and in front of others. A da’if hadith is a hadith which does not fulfil the conditions of the sahih or hassan hadith. Ruling: There is a difference of opinion between the ‘ulema on the ruling on acting upon weak hadiths. The reliable opinion is that weak hadiths can be acted upon for virtuous supererogatory deeds (fada’il al a’mal), for religious exhortation, and stories, and similar things that are not connected to legal rulings and tenants of belief. Keywords: Hadith, Hadith e Da’eef, Derivation of Ahkaam, Jurists, Different opinions.

Evaluation of Potential of Nigella Sativa Seed Extract for the Eradication of Helicobacter Pylori

Helicobacter pylori become a major cause of serious health problems and associated with an immense prevalence worldwide responsible for chronic gastritis and peptic ulcer. Therefore the effectiveness of Nigella sativa seeds against H. pylori was evaluated due to its broad range of pharmacological and antibacterial potential against pathogenic bacteria. The maceration method was followed to obtain crude seed extract (22.6 %) using methanol (90 %). This extract was further partitioned into subsequent fractions by following solvent-solvent extraction method using organic solvents according to their increasing polarity order. The percent yield of the resultant fractions were hexane (29.68 %), dichloromethane (15.6 %), ethyl acetate (1.56 %), butanol (18.75 %) and aqueous (34.37 %). The hexane fraction contained the highest value of total phenolic content (43.23 mg GAE/mL) followed by crude extract (40.88 mg GAE /mL). The total flavonoid content present in aqueous fraction (0.62 mg QE/mL) found higher as compared to the ethyl acetate fraction (0.437 mg QE/mL). The ethyl acetate fraction showed the highest percentage of scavenging activity (63.1 %) at 1000 ppm as compared to the other varying concentrations of studied fractions. Thymoquinone (TQ) was estimated and isolated by HPLC. The crude extract showed significantly higher amount of TQ (42.5 %) followed by present in hexane fraction (27.6 %). The thymoquinone was not detected in butanol fraction. The GC-MS analysis of fractions identified a total number of twenty one bioactive compounds including TQ. The FTIR analysis showed the presence of certain functional groups to the bioactive compounds in each fraction, which highlighted the importance of hexane and ethyl acetate fraction for containing prime antioxidant potential. The H. pylori bacterium was isolated and identified from the biopsy samples of infected patients (H. pylori positive). The in-vitro antibacterial activity was carried out against H. pylori, Klebsiella pneumoniae and Staphylococcus aureus. All the fractions and pure TQ was found active against H. pylori with zone of inhibition diameter (mm) ranged between 5.3 to 16.7 mm with minimum inhibitory concentration (MIC) varied in a range from 256 to 2048 μg/mL. Amongst the studied fraction the ethyl acetate fraction and TQ (256 μg/mL) demonstrated an equal highest inhibitory activity against the tested organisms followed by aqueous fraction (512 μg/mL). The butanol fraction with MIC (2048 μg/mL) remain inactive against all tested isolates. The radiolabelling of TQ (100 %) with technetium (Tc-99m) was achieved by following biodistribution and scintigraphic studies. The in-vitro and in-vivo assays were performed to assess the effectiveness of newly synthesized 99mTc- thymoquinone compound in an induced H. pylori infected mice model. The bioactivity of 99mTc-TQ was tested in an internalization assay demonstrated a promising interaction with muscle cancer cell line. Later on an effective dose of N. sativa seed was also determined through an in-vivo study designed for the treatment of H. pylori positive patients. Among the suggested trial dose rates the amount of 2.5 gram of N. sativa seeds per day had shown a promising inhibitory potential against patient’s recovery (80 %) from H. pylori. Current results provided prospects for the use of N. sativa seeds as a newly dietary supplement. TQ was proved to possess potential against H. pylori and contributed as a natural antimicrobial compound will possibly be used as a substitute for antibiotics.