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Home > Study of Cyp2c9, Cyp2c19 and Cyp2d6 Genetic Polymorphism in Pakistani Ethnic Groups

Study of Cyp2c9, Cyp2c19 and Cyp2d6 Genetic Polymorphism in Pakistani Ethnic Groups

Thesis Info

Author

Fizza Tariq

Supervisor

Aneesa Sultan

Department

Department of Biochemistry, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Page

90

Subject

Biochemistry

Language

English

Other

Call No: Diss / M. Phil / BIO / 4841

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676716023599

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تمنا ئے دیدارِ مرشد

تمنا ئے دیدار مرشد
تیرے شہر میں ہم بھی آئیں گے
قسمت نے دیا ساتھ تو دیدار بھی پائیں گے

تیرے شہر کی بہاریں بہت یاد آتی ہیں
تیری مخمور نگاہیں دل پہ تیر چلاتی ہیں
تیری ادائیں مجھ کو بہت ہی بھاتی ہیں
تیرے شہر میں ہم بھی نشیمن بنائیں گے

ہم ترس رہے ہیں تیرے دیدار کے لیے
ہم مارے مارے پھر رہے ہیں تیرے پیار کے لیے
ہم تڑپ رہے ہیں تیری محفل کے انوار کے لیے
کبھی تو تیری محفل میں دل کی پیاس بجھائیں گے

ہمارے شہر میں پیاء جب تشریف لائیں گے
غم زدہ لوگ غم کی داستان سنائیں گے
نگاہِ لطف و کرم جب وہ ہم پہ فرمائیں گے
ہمارے دل بھی خوشی سے جھوم جائیں گے

محبوب سے ہم بیٹھے ہیں بہت دور
مگر دل ملنے کو ہوا ہے مجبور
قسمت میں لکھا ہے تو ملیں گے ضرور
ان کو ملنے کے لیے ہم ان کے کوچہ میں جائیں گے

چاولہ سائیں ان کی ملاقات ہوہی جائے گی
حوصلہ رکھ نہ گھبرا رحمت کی برسات ہوہی جائے گی
سب مہربانوں سے مہربان رب کی ذات ہوہی جائے گی
اک دن وصل شراب محبوب ہمیں بھی پلائیں گے

سائنس اور تہذیب و تمدن کے فروغ میں اسلام کا کردار

Islam is a complete code of life. It has complete instructions regarding all aspects of life. There is no moment in human life when the wisdom of Islam has not benefited humanity. Likewise there is no such area in the world where Islam has not put the light of guidance. Allah Almighty has systematically administered this world system.  Allah created the universe and set it disciplined, then created man and gave him every kind of physical, rational, logical and argumintive ability, so that humans can know the secrets of the universe by thinking and understanding it. The journey of research and discovery, which started long ago, is still continues today after passing through different stages of research. This journey of research resulted in evolution of philosophy, civilization, promotion of new scientific innovations and discoveries. The research and discovery resulted in the secrets of heaven and earth.  Today, man stands at the stage of science and technology, about which the human being in the older days even could not imagine of it. In this entire evolutionary journey, the religion of Islam is the only religion that not only stood firmly with humans, but guided him at every step during this evolutionary journey. In this context, the Quranic teachings are comprehensive matter. Allamah Sayyuti says "There is no knowledge and problem that is not discussed in the Qur'an. So Islam invites human to research in the system of the universe and presents the system of universe for its authenticity.

Estimation of Gene Action and Selection Parameters in Quantitative and Qualitative Traits of Gossypium Hirsutum L.

An experiment was conducted in randomized complete block design with four replications in the experimental field of Botanical Garden, Department of Plant Breeding and Genetics, Sindh Agriculture University, Tandojam for assessing the heterosis, heterobeltiosis, inbreeding depression, combining ability, correlation and path coefficient analysis, genetic parameters and gene action for yield and yield components and seed viability in a set of 5x5 complete diallel cross of Gossypium hirsutum L. Phenotypic correlation coefficients (PCC) revealed that seed cotton yield/plant expressed strong positive (P≥0.01) association with sympodia/plant (r=0.863**), bolls/plant (r=0.921**) and boll weight (r=0.498*). Path coefficient analysis showed that the direct effect of bolls/plant and boll weight on seed cotton yield/plant was very high; 0.991 and 0.515, respectively and formed 118.94% and 183.99% of the total phenotypic correlation coefficient in F 2 generation. Heterosis was manifested in different crosses for all the characters but the extent of heterosis varied between characters. It may be assumed that heterosis in one or more than one yield components conferred heterosis for seed cotton yield. The cross Reshmi x TH-3/83, Reshmi x Mc-Niar-3150, CIM-109 x Mc-Niar-3150, CIM-109 x TH-3/83 and Mc-Niar-3150 x CIM-109 displayed positive heterosis and heterobeltiosis for seed cotton yield/plant alongwith one or more than one yield component characters. General reduction of heterosis in F 2 and in F 3 generation was due to decrease in heterozygosity through allelic fixation. Generally, predicted or expected inbreeding depression was quite higher than that observed for all the quantitative and qualitative traits except seed and lint indices, the discrepancy between the observed and expected inbreeding depression may be attributable to several reasons that involve linkage disequilibrium, epistasis and abnormal segregation at meiosis due to higher ploidy level of Gossypium hirsutum L. GCA variances were significant for plant height, sympodia/plant, bolls/plant, seed index, boll weight, lint index, G.O.T.% and seed cotton yield/plant, while SCA variances were significantly for plant height, bolls/plant and seed cotton yield/plant indicating additive and nonadditive type of gene action involved in the inheritance of these characters. Estimates of GCA effects of the parents indicated that TH-3/83, NIAB-78 and Reshmi were good generalxiii (xiii) combiners for seed cotton yield in F 2 generation due to their positive GCA effects. Parent Reshmi was also good combiner for plant height, boll weight, seed and lint indices, G.O.T.% and staple length followed by TH-3/83. Number of sympodial branches was of little importance in ranking the parents because parents that were good general combiner for yield and number of bolls did not hold a similar position for sympodial branches. The cross NIAB-78 x TH-3/83 performed better from rest of the crosses and displayed positive SCA effects in 10 out of 12 characters followed by cross NIAB-78 x Reshmi which displayed significant SCA effects in 9 out of 12 characters and express positive effects for yield and bolls/plant and reasonably positive effects for seed and lint indices. These crosses will form the superior combinations for hybrid crop improvement. Broad sense heritability computed through variance component method showed that all the quantitative traits were highly heritable in F 2 and F 3 generations except sympodia/plant. This suggests that selection for quantitative traits would be more rewarding than selection for qualitative traits in early segregating generations such as F 2 and F 3 . The trait seed cotton yield exhibited 73% broad sense heritability coupled with 31% expected genetic advance suggesting the existence of sufficient amount of genetic variability for improvement of this trait and also indicates that the trait is more amenable to selection and could be improved easily. The genetic components of variance for plant height, bolls/plant and boll weight in F 2 generation revealed that dominance components (H 1 and H 2 ) and additive component (D) were highly significant. It was further observed that dominance components were greater than additive components. Genetic components for seed cotton yield revealed that the dominance components were non-significant and greater than additive components. The average degree of dominance was more than unity, displaying over dominance type of gene action. The positive non-significant F-value revealed that the dominant genes were less frequent than recessive genes in the parents and that they were in decreasing position as exhibited by h 2 value. Estimated ratio of h 2 /H 2 indicated that there were atleast three groups of genes controlling seed cotton yield/plant. The value of r 2 showed the complete dominance of parents. Seed vigour was measured through the germination percentage and electrolyte leackage of seeds. Hybrids Reshmi x NIAB-78 and CIM-109 x TH- 3/83 displayed maximum germination percentage at 30 and 35 o C, of seeds from bottom portion of the plant and these crosses displayed moderate electrolyte leackage and were considered as vigourous seed when taken from bottom and middle portions of the plant.