جوشؔ ملیح آبادی
پاکستان ہی میں اردو کے مشہور شاعر جوش ملیح آبادی کی وفات ہوئی، انھوں نے اردو شاعری کی صنف نظم گوئی کو بڑی ترقی دی، غزل کے بجائے نظم گو کی حیثیت سے زیادہ مقبول ہوئے، ان کے مداح ان کے فن اور شاعرانہ مہارت کے بڑے قدردان رہے، مگر ان کے کچھ ناقد ایسے بھی ہیں، جو ان کی شاعری ہی میں خیالات کی بلندی اور پاکیزگی کے بجائے صرف گھن گرج اور چیخ و پکار زیادہ پاتے ہیں، دینی حلقوں میں تو اپنے ملحدانہ اور رندانہ طرز فکر کی وجہ سے اچھی نظر سے نہیں دیکھے جاتے، مگر جب کبھی اردو شاعری کی تاریخ لکھی جائے گی تو اس میں ان کے شاعرانہ فن کی وجہ سے ان کو نمایاں جگہ دی جائے گی۔ (صباح الدین عبدالرحمن، اپریل ۱۹۸۲ء)
Rhetoric is a branch of Arabic sciences through which the literal figuration of the Holy Quran can be defined and understood Many scholar have paid close attention to the literal figuration and emphasized on it in every era to discover and find out the literal and eloquent beauties of the meaning of the words of the holy Quran. In this article we have tried to study and find out the literal figuration : its beauties and impacts on readers of the holy Quran especially in suratul- Anfal surah- altaubah and surah younas
Human brain development is a complex process involving many cellular pathways. Pathogenic mutations in genes controlling as a whole or in parts, any of these cellular processes result in neurological disorders. It is basically due to defective signaling function in central or peripheral nervous system. The clinical features of such disorders are extremely diverse and overlapping, with even greater genetic heterogeneity. They may either be simple, having Mendelian inheritance or they may be complex. Genetic factors play very important role both in simple and complex neurological diseases. The consequences of such diseases are usually devastating both for affected individuals, their families and society, mainly by affecting the qualities which make human special as person; the character, memory, cognition, communication and skilled movements. In the present study, 11 consanguineous Pakistani families having neurological disorders of Mendelian inheritance were investigated using next generation sequencing (NGS) technologies. Rare and disease causing variants mostly occur in coding part of genome. Whole exome sequencing (WES) was used as a method of choice in the current study because of the heterogeneous nature of neurological disorders both clinically and genetically. Variants obtained from WES were prioritized based on their inheritance pattern, disease association, functional relevance and pathogenicity score as predicted by different bioinformatics tools such as Mutation Taster and PolyPhen-2. Segregation of all the variants were confirmed using Sanger sequencing. Ten novel and one already reported mutation were identified in this study. At present there are no effective treatment strategies available for most of these diseases. Therefore, identification of gene/s and pathogenic variant/s in these diseases will help understand underlying molecular mechanisms better, and lead to improved strategies both for genetic counseling and potential therapeutics