سید شاہ محمد محی الدین پھلواروی
افسوس ہے پچھلے مہینہ اپریل کی ۲۲؍ تاریخ کوصوبۂ بہار کے امیر شریعت اورپھلواری شریف کی خانقاہِ مجیبیہ کے سجادہ نشین مولانا الحاج السید شاہ محمد محی الدین صاحب نے صبح کے وقت تقریباً آٹھ بجے وفات پائی۔مولانا علم وعمل، تقوی وطہارت اوراخلاق وعادات کے اعتبار سے علمائے سلف کانمونہ تھے۔ آپ کاروحانی اوراخلاقی فیض واثر بہت وسیع تھا اور آپ کی ذات لاکھوں مسلمانوں کی عقیدت وارادت کامرکز تھی۔اب جبکہ وقت آرہاتھا کہ امارتِ شریعت کاادارہ سیاسی محکومیت کی بندشوں سے آزاد ہوکر اپنے فرائض وواجبات صحیح طور پرانجام دے سکے۔آپ ایسے بزرگ کا رحلت کرجانا مسلمانوں کے لیے جس قدر بھی افسوس اور رنج والم کاباعث ہوکم ہے۔ بہرحال مشیتِ ایزدی میں کسی کوکیا مجالِ دم زدن ہے۔ اﷲ تعالیٰ حضرت مرحوم کوجنت الفردوس میں مقامِ جلیل عطافرمائے اور بیش از پیش نعمتوں اورنوازشوں سے سرفراز فرمائے ۔آمین۔
اسی شمارہ میں مولانا مرحوم کے حالات وسوانح پرایک مختصر مقالہ بھی شریکِ اشاعت ہے۔ [مئی ۱۹۴۷ء]
Islam and Mysticism or tasawuf have coexisted. Sufism has flourished in all Muslim dominated regions. Sufism is a mode of spirituality within Islam. Sufi schools teach three parts: Shariah, Tariqah and Haqiqh. In this article, traditional thoughts in Sufism and its impacts on the world especially in the region of Indo-Pak have been discussed. The shrines of Pakistani Sufis are the centers of inspiration for mysticism and spirituality that influence cultures and civilizations.
The work presented in this thesis concerns the synthesis of various sulfonamide derived Schiff bases by the equimolar reaction of sulfonamides e.g., sulfamethazine, sulfadiazine, sulfathiazole, sulfanilamide, sulfamethaxazole, 4-(2-aminoethyl)benzene sulfonamide, 4- (methyl)benzenesulfonamide, sulfisoxazole and sulfaguanidine with the respective aldehydes such as 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde and 2- hydroxynaphthaldehyde. The free amino group (NH2) of the sulfonamide moiety condense with the carbonyl (HC=O) group of aldehydes to achieve the target of twenty- one new sulfonamide derived Schiff base (L1)–(L21) compounds. The structures of newly synthesized sulfonamides were elucidated by their physical, spectral (IR, 1H and 13 C NMR and mass) and analytical (CHN analysis) data. X-ray diffraction studies on nine sulfonamides were carried out to confirm the structures of 4-(5-chloro-2- hydroxybenzylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (L1), 4- [(E)-(5-chloro-2-hydroxybenzylidene)amino]benzenesulfonamide (L4), 4-{2-[(5-chloro- 2-hydroxybenzylidene)amino]ethyl}benzenesulfonamide (L6), 4-chloro-2-[(E)-({4-[N- (3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl}iminio)methyl]phenolate (L8), 4-[(5- bromo-2-hydroxybenzylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfon amide-4-bromo-2-[(E)-({4-[(4,6-dimethyl-pyrimidin-2-yl)sulfamoyl]phenyl}iminio) methyl]phenolate (L10), 4-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzene sulfonamide (L13), 4-{[(E)-(5-bromo-2-hydroxyphenyl)methylidene]amino}-N-(5- methyl-1,2-oxazol-3-yl)benzenesulfonamide benzylidene)amino]ethyl}benzenesulfonamide (L14), 15 (L ) 4-{2-[(5-bromo-2-hydroxy and 4-bromo-2-((E)-{4-[(3,4- dimethylisoxazol-5-yl)sulfamoyl]phenyliminiomethyl)phenolate (L17). The synthesized sulfonamide derived Schiff base were used as ligands for complexation reaction with a number of metalloelements [Co(II), Ni(II), Cu(II) and Zn(II)] using in a molar ratio of L : M as 2 : 1. The nature of bonding and structure of all the metal(II) complexes have been deduced by their physical (conductivity, magnetic measurements), spectral (IR, 1H and 13 C NMR and electronic) and analytical (CHN analysis) data. The result of these studies revealed an octahedral geometry for all the metal(II) complexes. Due to amorphous nature of the metal(II) complexes, their crystals could not be formed for X-ray diffraction studies. In order to evaluate the biological role of these compounds and the effect of metalloelements on the nature of their biological activity, all the synthesized compounds were screened for their in vitro antibacterial, antifungal and cytotoxic activities against four Gram–negative (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa and Salmonella typhi) and two Gram–positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and against six fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata) using agar-well diffusion method. The result of these studies revealed that majority of the compounds showed significant (~80%) to moderate (~50%) antibacterial/antifungal activity. The activity however, was enhanced upon chelation/coordination with the metalloelements: some compounds, which were non- active, became active and moderate active became significantly active. Amongst all the compounds, the zinc(II) complexes showed the highest activity. The brine shrimp (Artemia salina) bioassay was also carried out to study in vitro cytotoxic activity. These studies revealed that several compounds displayed potent cytotoxic activity as LD50 in the range of 4.898 x 10-4 to 6.745 x 10-4 M/mL.