’’صدیق کے لئے ہے خدا کا رسول بس‘‘
امت کے بہترین افراد کو نبیصلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کے نام سے یاد کیا جا تا ہے ، یہ ایسے نفوس قدسیہ ہیں جن کے پیشِ نظر نزول وحی ہوتا ہے۔ جن کی نظر یں جلوۂ نبوت کا طواف کرتی ہیں۔ جن کے کانوں سے زبانِ مصطفیٰ صلی اللہ علیہ و آلہٖ وسلمسے نکلنے والے الفاظ معانقہ کرتے ہیں، جن کی کفِ پانقش نعلینِ مصطفی صلی اللہ علیہ و آلہٖ وسلمکی تلاش میں سر گرداں رہتی ہیں، جن کے شب وروز معجزات نبی صلی اللہ علیہ و آلہٖ وسلم کا مشاہدہ کرتے رہتے ہیں، نبی صلی اللہ علیہ و آلہٖ وسلمکی نظر یں جن کی تربیّت کرتی ہیں، جن کی آنکھوں میں نبوت سراپا، قلوب و اذہان میں نبی صلی اللہ علیہ و آلہٖ وسلمکی سوچ اور تعمیر میں نبی صلی اللہ علیہ و آلہٖ وسلم کا کردار پیش نظر ہوتا ہے۔
جس طرح جملہ انبیاء کرام علیہ السلام میں گنبدِخضریٰ کے مکین کا کوئی ثانی نہیں ہے۔ اسی طرح آپ صلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کی بھی مثال دیگر انبیاء علیہ السلام کے صحابہ سے نہیں ملتی۔ حضور صلی اللہ علیہ و آلہٖ وسلم کے تمام صحابہ کرام رضوان اللہ تعالیٰ اجمعین آپ صلی اللہ علیہ و آلہٖ وسلم کے جانثار تھے لیکن جانثاری کی جو مثالیں صدیقِ اکبر ثنے قائم کیں۔ تاریخ کے اوراق ایسی مثال سے قاصر ہیں۔ تاریخِ اسلام کا مؤرخ ایسی مثال پیش کرنے سے قاصر ہے، تاریخِ عالم رقم کرنے والے جملہ مؤرخین ایک عظیم محبت اور جانثاری کی مثال دینے کیلئے اپنے لبوں کو اور اپنے قلم کوجنبش دینے میں بے بس نظر آتے ہیں۔ سیدنا صدیقِ اکبر ص کا اوڑھنا بچھونا سنت ِمصطفی صلی اللہ علیہ...
The foreign exchange market plays an important role in the formation and development of financial markets. This market is of particular importance for emerging economies. To understand market trends (to understand and develop a strategy for its development), it is necessary to analyze historical data. It is also important to use different methods to carry out this analysis. Based on this, the paper analyzes the foreign exchange market in Ukraine for the period 2014-2018. For this analysis, the wavelet coherence methodology is used. This made it possible to assess the development of the foreign exchange market in Ukraine.
Inducible cyclo-oxygenase (COX) expression in the brain is associated with acute neurotoxicity, such as seizures and ischemia. On the other hand COX 1 and 2 both are related to delayed pro-inflammatory activities, which are ought to exacerbate the neuronal damage in neurodegenerative diseases. It was postulated in last decade that non steroidal anti-inflammatory drugs (NSAIDs) which are widely used in clinical situation as anti-inflammatory, analgesics and antipyretic drugs by inhibiting COX pathway in brain can prevent neurodegeneration. However it is still unknown whether NSAIDs have effect on the development on the central nervous system and play a major role to prevent and treat neurodegenerative disease. Previous clinical, epidemiological and experimental data revealed that repeated and long term use of NSAIDs prevent neurodegeneration by inhibiting brain COX isoenzymes and recommended as a new emerging approach. In the present study we aimed to evaluate the effect of diclofenac, ibuprofen and celecoxib on behavioral and biochemical parameters as well as disease severity assessment not only in parkinson’s patients but on chlorpromazine induced parkinson rat model. A single blind clinical study was conducted in four groups of 40 parkinson’s patients. The cognition was measured by MMSE and MoCA test, depression assessed by HDRS test, daily living functioning judged with ADCS-ADL scale and disease severity by Hoehn & Yahr staging and descriptive UPDRS scale. The outcomes were better among patients treated with NSAIDs than control patients. NSAIDs treated patients showed significant improvement in MMSE, MoCA and ADCS-ADL scores after 2 month treatment period from baseline score. However insignificant results were also observed after 2 month treatment with respect to depression and disease severity. The most frequent adverse events during 2 month treatment period were nausea, dyspepsia, elevated hepatic enzymes, and hypertension. NSAIDs showed significant increased SGOT, SGPT, and bilirubin levels but no significant change in GGT and alkaline phosphatase after 2 month treatment was noted. NSAIDs showed significant increased levels of urea and creatinin after 2 month. We found elevated Cortisol levels at baseline in all parkinson patients after taking NSAID we observed slightly reduced levels of cortisol from baseline as compare to control patients but results were insignificant. Behavioral and histopathological examination of NSAIDs treated rats after chlorpromazine induced parkinsonism was observed. NSAIDs were administered after 30 minutes of 3mg/kg ip injection of chlorpromazine up to 21 day. After 21 day we observed significant motor impairment in CPZ treated rat in open field, catalepsy and wire hanging test while NSAIDs treated rat showed significant improvement comparable to standard L-dopa/carbidopa group. NSAIDs treated rats showed significant improved cognitive behaviors in radial arm maze, water maze and passive avoidance test as compare to control and CPZ group. Depression was marked with CPZ group on forced swimming induced test and cage crossing test while NSAIDs treatment improved depression after 21 days. NSAIDs treated rats slightly reduced their weight after 21 days as compare to control and CPZ group while CPZ group significantly increased body weight. Anxiety was assessed by using elevated plus maze. NSAIDs showed anxiety like behavior after 21 day treatment but CPZ treated rats showed anxiolytic effect. Histopathological examination of brain tissue of NSAIDs treated group revealed minimal neuronal destruction and gliosis as compare to CPZ group. In conclusion results of this clinical and experimental study explain that NSAIDs treatment show moderate improvement in parkinson associated cognitive decline, motor impairment and in their daily life function. Adverse drug events were also observed, hence prolong use can only be recommended after extensive study.