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Monitoring the Recommended Treatment Protocol for Pneumonia in Children: Intervention to Improve Clinical Outcome

Thesis Info

Author

Iqra Sohail

Supervisor

Gul Majid Khan

Department

Deparment of Pharmacy, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Page

vii, 114

Subject

Pharmacy

Language

English

Other

Call No: Diss / M. Phil / BIO / 4767

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676716372018

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تیراک

تیراک

وجیہہ ضمیر

پورا دن گزر گیا اور شام ہونے والی ہے۔ دریائی پانی کے بہاو پر شفق کے عکس کی چادر تن گئی ہے۔ بوڑھا ماہی گیر، جس کے ماتھے کی شکنیں مزید گہری اور ایک دوسرے کو کاٹنے لگ گئیں۔وہ تھکن کے احساس سے بڑبڑانے لگا۔"آج کا دن ہی کچھ منحوس تھا۔کوئی بڑی مچھلی ہاتھ نہ آئی"۔ بوڑھے ماہی گیر کا معاون، اٹھارہ برس کا کھلنڈرا جوان ہے۔جسےاس کی بوڑھی بیوہ ماں نے، مچھلیاں پکڑنے کے گر سیکھنے کےلیے اس کے پاس چھوڑ رکھا تھا۔یہ انتہائی جذباتی، متجسس اور ہر وقت اپنی ذات کے اندر بے تکے سوالوں کی ٹر ٹر لگائے رکھتا تھا۔ وہ ہر لمحہ کچھ نہ کچھ سوچتا ہی رہتا،خود ہی سوال اٹھاتا اور خود کو ہی جواب دے کر مطمن کر دیتا۔ لیکن پچھلے کچھ عرصے سے خدا کا منطقہ اس کے ذہن میں یوں اٹک گیا جیسے گلے میں ہڈی پھنس جاتی ہے۔سارا دن یہ سوال مسلسل پوچھ پوچھ کر اس نے اپنے استاد کا سر کھا لیا۔استاد اسے بےوقوف لڑکا سمجھتے ہوئے کئی طرح سے ٹالتا رہا۔ لڑکے نے آخری بار پوچھنے کا فیصلہ کرتے ہوئے ذرا تیکھے پن سے کہا:

"استاد! اب بتاو ہی دو، یہ خدا کس بلا کا نام ہے؟"

استاد نے جال سمیٹے اور تیوری چڑھاتے ہوئے، اسے دیکھا اور بولا۔"بکو مت، یہ کیا بکواس کر رہے ہو سنو ۔ خدا نظر نہیں آتا، لیکن رحم و کرم سے بھرپور اور انسان سے محبت کرتا ہے۔" لڑکے کے ذہن میں اٹکا یہ معاملہ جیسے سلجھ گیا ہو۔ وہ پہلے زیر لب مسکرایا، پھر ہنسا، پھر قہقہے لگانے شروع کر دیے اور رواں گہرے پانی میں چھلانگ لگا دی۔ شاید اس نے یہ سوچا ہو گا کہ مجھے بھی نظر نہیں آ...

انسانی حقوق کا جدید فلسفہ اسلامی تناظر میں

The concept of freedom and equality enshrined in democratic systems though solves certain individual problems, but at the same time many collective problems arise. In this context, these democratic values become inconsistent with principles of Islamic political system because the concept of freedom and equality in Islam is different from that in western democracy. The Islamic Sharīʻah has divided the obligatory duties into Ḥuqūqul Allah and Ḥuqūq-al-ʻIbād and complying with them guarantee the success in this world and the hereafter. Islam not only connects rights and responsibilities with each other, but also determines their priorities. Those societies where an imbalance is created in discharging duties and rights get caught up in mischief and trouble as an unavoidable consequence as if human beings play the main role in the construction and destruction of societies. Keeping in mind the above mentioned issues, the reality of modern philosophy of human rights and its basic criterions and effects in Islamic perspective has been reviewed to find the causes of failure of modern philosophy in protecting the human rights in the contemporary era. Similarly, explaining the concept of human rights in Islam in modern perspective, a research-based analysis has been presented in this paper.

Bioconversion of Agricultural Waste to Alginate by Azotobacter Vinelandii Using Fermentation

Alginate is an exopolysaccharide composed of varying ratios of β-D mannuronic acid and its C5 epimer α-L-guluronic acid linked together by β-1,4 - glycosidic bond. It has wide range of industrial applications particularly in food sector as a viscosifier, stabilizer, thickener, emulsifier, gelling and water binding agent. Commercial alginate is extracted from brown algae but due to variation in composition of biopolymer isolated from species of different locations, there is growing interest in bacterial alginate. At present two strains of bacteria are reported to produce alginate, Pseudomonas and Azotobacter. Hence present study was designed to produce alginate by Azotobacter vinelandii utilizing cheap substrates to save the foreign exchange. To achieve the goal, different physiochemical parameters were optimized to have hyper-production of alginate through submerged fermentation. Different agricultural wastes like wheat bran, rice polishing and molasses were utilized as substrates through fermentation with Azotobacter vinelandii.On fermentation of 7.5% (w/v) wheat bran by A.vinelandii, maximum alginate production (5.21 g/L) was observed at 48 hours of incubation time with 6% (v/v) inoculum size, pH 7.0, 300C and agitation speed of 200 rpm. Addition of different optimum levels of ionic salts i.e. 1.5% CaCl2 and 2% MgSO4. 7H2O in the growth medium gave significantly (P< 0.05) higher quantity of alginate (6.08 g/L) where as addition of KH2PO4 and NaCl reduced the yield of alginate. Among different nitrogen sources tested, 2% corn steep liquor resulted significantly (P<0.05) higher yield of alginate (7.46 g/L). The bacterial strain was improved by exposure to physical (UV irradiation) and chemical mutagens (Nitrous acid and ethidium bromide) to obtain more than 90% killing. The survivors were screened for hyper-production of alginate against the wild strain of A.vinelandii using pre- optimized conditions. The highest alginate production (13.8 g/L) was obtained by the ethidium bromide treated strain (EtBr-02). The mutant strain was used for optimization of fermentation parameters. The maximum concentration of alginate (15.61 g/L) was obtained by utilizing 10% (w/v) wheat bran, 8% (v/v) inoculum at 48 hours of incubation, pH 7.0, 300C and an agitation speed of 200 rpm. Inclusion of 2.5% cornsteep liquor raised the alginate concentration to 15.8 g/L. Batch fermenter studies were carried out in 2 L fermenter with working volume of 1.5 L using the mutant strain A.vinelandii, EtBr-02. Optimization of process parameters like agitation, aeration and pH in the fermenter showed that maximum alginate (16.8 g/L) was achieved at 300 rpm, 2.5 vvm aeration and controlled pH condition at 32 hours of incubation time. The alginate produced was identified by FTIR spectrum after precipitation. The purity of alginate was estimated by HPLC against the standard alginic acid from Sigma-Aldrich and was found to be 98% pure. The alginate produced was used at 3% concentration for immobilization of yeast cells. Immobilized and free cells were compared for ethanol production using 10% sucrose as the carbon source in fermentation medium. The maximum amount of ethanol obtained was from free cells i.e. 38 g/L whereas immobilized cells produced 32.5 g/L ethanol. The advantage of immobilization is that beads can be reused in eight sequential fermentation cycles of 10 h each. Thus a cheap and practical bioprocess of alginate production was developed, that can be exploited commercially to save foreign exchange.