تنبيهات الحافظ ابن حجر في فتح الباري على الإمام الكرماني في الکواکب الدراري في الإتصال والإنقطاع: دراسة نقدية مقارنة

Sahih al-Bukhari a collection of ahadith of Mohammad (PUUH) compiled by Imam Abu Abdullah Muhammad al-Bukhari, has been given great importance by the Muslim scholars of past and present time. Many detailed commentaries on this collection have been written So the number of methods have been increased during the commentary of this book. Some of them explained it in detail, and some concerned with a particular aspect. “Al Kawakib Ad Durari” by Imam Alkirmani is an old explanation of Sahih Bukhari. Many commentators came after Imam Alkirmani consulted his book, and quoted his statements in their books; sometimes agreeing, and at other times contravention. Imam Alkirmani was among those scholars who were expert in many fields at a time like know-ledge about hadith, its narrators, commentary, qiraat, Quranic science, Islamic Jurisprudence, Arabic language, Faith, medicine, history, geography, astronomy etc. During studying “Fath al Bari”I found that Alhafiz Ibne Hajar criticized on the commentary of Alkirmani at many times in relating to the continuation and discount-inuation of traditions. In this article I studied these comments of Alhafiz Ibne Hajar on Imam Alkirmani a critical comparison. After research I have found that Alhafiz Ibne Hajar has consulted “Al Kawakib Ad Durari” and quoted Imam Alkirmani’s commentary and added it. This article approves that the opinion of Alhafiz Ibne Hajar is more reliable than Imam Alkirmani.

Effect of High Protein Diet on Pancreatic B-Cell Regeneration & Funtioning in Diabetic Rats

Diet is a key factor in fulfilling energy requirements, maintaining metabolic homeostasis and promoting health. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defective insulin production or secretion from pancreatic β-cells, insulin function or both. The type, amount as well as balance of main macronutrients (proteins, fats and carbohydrates) present in diet are of particular significance in managing the diabetes. However, relatively little is known about the underlying molecular mechanism that how protein rich diet is responsible for functional changes in pancreatic β-cells. Current study was intended to evaluate the effect of high protein diet on body weight, glycaemic control, regeneration of β-cell, production and release of insulin in diabetic rats. High protein diet (45% and 55% fish protein) was administered in alloxan induced diabetic rat model for a period of 28 days. Blood samples were collected for monitoring blood glucose level, lipid profile and other biochemical parameters. Pancreatic tissue samples were collected for histopathological study. The data was subjected to statistical analysis by applying one way ANOVA and DMR. Results revealed that protein rich diet counteracted the reactive oxygen species (ROS) and normalized the elevated levels of blood glucose (198.1±11.5), cholesterol (64.73±2.24) and triglycerides (65.97±4.62) compared to positive control group having serum glucose (606.8±12.3), cholesterol (95.36±4.6) and triglycerides (109.5±3.51) respectively. Histopathological analysis revealed that high protein diet helps in normal regeneration or replenishing of β-cells. The role of calcium and cellular stress pathways are important in underlying mechanism behind the ROS production and its control as low expression levels of Calm-2, Grk-2, Pias-2, Traf-4, Traf-6 and MAPK-8 genes were observed in high protein diet treated groups in comparison to positive control. High protein diet also improved β-cell function and performance by up regulating the expression of INS-1, INS-2 & Pdx-1 genes. In conclusion, results indicated the regenerative and protective potential of high protein diet in alloxan-induced diabetic rat model.