عبدالحمید، حکیم
’’ملک و ملت کا مسیحا نہیں رہا‘‘
بالآخر وہی ہوا جس کا کھٹکا مہینوں سے لگا تھا اور اس مسیحا نفس نے اپنی جان جان آفریں کو سپرد کردی، جس کی مسیحائی سے لاکھوں نے زندگی پائی تھی، حق یہ ہے کہ حکیم عبدالحمید کی وفات پر بھی وہی الفاظ دہرائے جائیں جو مسیح الملک حکیم محمد اجمل خاں کی وفات پر مولانا سید سلیمان ندویؒ نے تحریر فرمائے تھے حکیم صاحب کی وفات خاندان کا ماتم نہیں، دلی کا ماتم نہیں، قوم کا ماتم ہے، فضل و کمال کا ماتم ہے، اخلاق و شرافت کا ماتم ہے، سنجیدگی و متانت کا ماتم ہے، عقل و رزانت کا ماتم ہے، آزادی و حریت کا ماتم ہے، اخلاق و ایثار کا ماتم ہے، ہندوستان اور مسلمانان ہند کے طالع و بخت کا ماتم ہے۔
مرثیہ ہے ایک کا اور نوحہ ساری قوم کا
حکیم عبدالحمید کا دائرہ فیض و خدمت بہت وسیع تھا، ان سے پورا ملک مستفیض ہورہا تھا۔ ہمدرد کی دوائیں سکہ رائج الوقت کی طرح گھر گھر پھیلی ہوئی ہیں اس لیے آج سب ہی اس محسن اعظم کی جدائی پر اشک بار اور ماتم کناں ہیں۔
عمت فواضلہ فعم مصابہ
حکیم صاحب جس بدنصیب ملت کے فرد فرید تھے اس میں بڑا قحط الرجال ہے، وہ تنہا اپنی ذات سے ایک انجمن، ایک ادارہ، ایک جماعت اور ایک قوم تھے، ان جیسے پیکر صدق و اخلاص اور سراپا خدمت و عمل کا اٹھ جانا عجب سانحہ اور ملت اسلامیہ کا زبردست خسارہ ہے، سمجھ میں نہیں آتا کہ اس کی تلافی کیسے ہوگی اور اس غم کا مداوا کیا ہوگا۔ بلا شبہ وہ اس عہد کے مسیح الملک، ابن سینا اور رازی تھے۔
حکیم عبدالحمید کا خاندان تجارت پیشہ تھا۔ یہ چینی ترکستان کے شہر کا شغر سے...
The downloading of the legal rulings on the facts and their transfer from abstraction to application needs a deep philosophical look from Mujtahid and Mufti. Among the things that must be taken into account consider individual differences between taxpayers because these differences may require a change in the Shari'a ruling by the change of the person who owns the incident according to its characteristics and conditions, from the clues that it embraces and requires this change. This indicates that individual differences between taxpayers should be taken into account during tinnitus litigation which is seen as a pilgrimage to the origins of the Sharia and its general rules and its effects were manifested and manifested in the methods and methods of fundamentalists and jurists.
Inorganic nanoparticles based assembly of ‘all-in-one’ multifunctional nanocomposites has been synthesized for in vitro magnetic resonance imaging, pH sensitive, light-triggered and magnetic field triggered drug release and for combined phototochemotherapy. Development of dual encapsulated antibody-targeted photosensitizing liposomes for in vivo imaging and combined phototochemotherapy is also demonstrated. Superparamagnetic iron oxide nanocomposites (IONCs) were formed through a microwave-assisted green approach using fruits peel extracts as reducing and capping agents. This involves the stabilization of IONCs through co-ordination of different phytochemicals. The IONCs were extensively characterized for structural, elemental, magnetic and physicochemical analysis, and were found physically and chemically stable with a shelf life stability of 20 days, an average size of 23.35 ± 4.99 nm and mean band gap value of 2.8 ± 0.17 eV. IONCs exhibited excellent water dispersibility, colloidal stability and haemocompatibility. High saturation magnetization (58.8 ± 3.08 emu/g) coupled with superparamagnetic property makes IONCs ideal candidates for magnetic hyperthermia and drug delivery application. Relatively high r2 relaxivity 228.25 mM-1 s-1 were found 1.2 folds higher than the commercial Resovist®. Cell viability assay data revealed that PEGylation or carboxylation of these IONCs appear to significantly shield the surface of the particles. Nickel Oxide based core-shell nanoconstruct with Doxorubicin loaded core and folic acid connected BSA shell (NDOX@BSA-FA) induced approximately 5 folds higher cell killing than the NiO through photo triggered DOX release and in vitro ROS production from the NiO core. The entrapped drug from NDOX@BSA-FA was released in sustained way in a pH sensitive environment while a robust release was observed on photoirradiation. The Diphenylbenzofuran (DPBF), Tetrazolium bromide (MTT) cell viability and Thiobarbituric acid reactive substances (TBARs) assays revealed the photodynamic treatment potential of these core shell nanoconstructs. Further, the combined effect of DOX and NiO from NDOX@BSA-FA demonstrated an eight fold higher effective photokilling when compared with the free DOX. The merits of naturally occurring polysaccharides chitosan(CS), carboxymethyl cellulose (CMC) and natural protein bovine serum albumin (BSA) were combined with magnetic NiFe2O4 (NFs) cores and chemotherapeutic drug Paclitaxel (PTX), to design PTX and NFs loaded bionanocomposites (BNC) with folic acid (FA) modified surface for potential biomedical applications. Nontoxicity, hydrophilicity, and cancer-specific capability of these biopolymers endow the magnetic cores with excellent aqueous dispersibility as well as the 2 “stealth” property, which may prolong the circulation time of the BNC in blood stream. These BNC showed superior transversal relaxation rate r2 of 349 mM-1 s-1 along with folate receptor-targeted and magnetically directed functions were found physically and chemically stable over a period of 60 days. Application of an external magnetic field effectively enhanced the PTX release with 2 folds higher selectivity of folate conjugates when compared with nonfolate conjugates. A robust, physically, chemically and optically stable photosensitizing liposomal platform has been successfully developed, comprising hydrophobic photosensitizer, benzoporphyrin derivative molecules within the phospholipid bilayer as a lipid conjugate and surface density of strained cyclooctyne moieties was optimized to mediate copper free click conjugation of photosensitizing liposomes to azido functionalized antibodies. A successful formulation of near infrared deep tissue imaging dyes into antibody-targeted photosensitizing liposomes designed for in vivo tumor imaging has been achieved. Further we developed targeted Lyso Pc-BPD and Carboplatin/Gemcitabine coencapsulated photosensitizing liposomes by loading the chemotherapeutics within antibody targeted photosensitizing liposomal formulations in all aspects of synthesis, characterization, validation and reproducibility for combined chemo and photodynamic therapy. Integration of multifunctional probes and conjugation strategies push the boundaries of combination therapies beyond the conventional monotherapies.