مولانا شاہ بدرالدین
ابھی گزشتہ مہینہ کے معارف میں ہم نے حضرت امیر شریعت صوبہ بہار اور امارت شرعیہ صوبہ بہار کا تذکرہ کیا تھا، خیال میں بھی نہ تھا کہ اس کے ایک ہی مہینہ کے بعد ہم کو حضرت ممدوح کی دائمی مفارقت کا ماتم کرنا پڑے گا، حضرت مولانا شاہ بدرالدین سجادہ پھلواری اس عہد کے جنید و شبلیؒ تھے، ان کا زہد و ورع، نزاعت و ارتقاء، علم و عمل، صورت و سیرت، ہر چیز نمونۂ سلف تھی، کم و بیش چالیس برس تک یہ علم و عرفان کی شمع صوبۂ بہار میں روشن رہی اور اس کی روشنی دور دور تک پھیلتی رہی، ان کے شب و روز کے چوبیس گھنٹے ذکر و فکر اور مطالعۂ کتب کے سوا اور مشاغل میں کمتر صرف ہوتے تھے، ان کی نشست گاہ ایک کتب خانہ تھی، ان کے چاروں طرف کتابوں کا انبار لگا رہتا تھا اور اس کے بیچ میں یہ زندہ کتب خانہ جلوہ فرما رہتا تھا، اس عہد میں یہی ایک ہستی تھی جو ظاہر و باطن، علم و معرفت، حقیقت و شریعت کا مجمع البحرین تھی اور جس سے ہزاروں اور لاکھوں علم و معرفت کے پیاسے سیراب ہوتے رہتے ہیں، پھلواری کا سجادہ اس بزرگ ذات کی رونق افروزی سے چشمۂ خورشید تھا، افسوس کہ یہ آفتاب اب ہمیشہ کے لئے ڈوب گیا۔
وہ میرے والد مرحوم کے پیر بھائی تھے، دونوں مولانا شاہ علی حبیب صاحب قدس سرہ، سجادہ نشین پھلواری سے مستفید تھے، خاکسار کو آغاز عمر میں ۱۸۹۸ء میں پھلواری کی خانقاہ میں چند ماہ بسلسلۂ طلب علم والد ماجد مرحوم کے حسب ہدایت رہنے کا اتفاق ہوا تھا، اس وقت سے اخیر عمر تک اس ہیچمدان پر خاص نظر عنایت تھی، کبھی کبھی مکرمت ناموں سے سرفراز فرماتے، تو ’’اعزا خواں‘‘ کے...
Establishment of khilafah and tamkeen fil ‘ard means supremacy of the dictates of shari‘ah and socio-political justice on earth. This is one of the basic objectives and prominent messages of the Holy Quran and Seerah of Prophet Muhammad (s.a.w). About khilafah and tamkeen fil ‘ard the Holy Quran expresses as: -وَعَدَ اللَّهُ الَّذِينَ آمَنُوا مِنكُمْ وَعَمِلُوا الصَّالِحَاتِ لَيَسْتَخْلِفَنَّهُم فِي الأَرْضِ … -الَّذِينَ إِن مَّكَّنَّاهُمْ فِي الأَرْضِ أَقَامُوا الصَّلاَةَ وَآتَوُا الزَّكَاةَ وَأَمَرُوا بِالمَعْرُوفِ وَنَهَوْا عَنِ المُنكَرِ وَلِلَّهِ عَاقِبَةُ الأُمُورِ. -هُوَ الَّذِي أَرْسَلَ رَسُولَهُ بِالْهُدَى وَدِينِ الْحَقِّ لِيُظْهِرَهُ عَلَى الدِّينِ كُلِّهِ وَكَفَى بِاللَّهِ شَهِيداً. Prophet Muhammad (s.a.w) proclaims: - وَاَللَّهِ لَوْ وَضَعُوا الشَّمْسَ فِي يَمِينِي وَالْقَمَرَ فِي يَسَارِي عَلَى أَنْ أَتْرُكَ هَذَا الْأَمْرَ حَتَّى يُظْهِرَهُ اللَّهُ أَوْ أَهْلِكَ فِيهِ مَا تَرَكْتُهُ. The Holy Quran and the Seerah refer to some underlying milestones on the way of religious nations to status of khalafah and tamkeen fin ‘ard. These milestones may be expressed in an order as: da‘wah [preaching], deen [practices of prophetic teachings], hijrah [migration], ma‘iyyat-ul-Allah [companionship of Allah], qital [wars], nusrat-ul-Allah [divine aid], izhar-ud-deen [domination of deen] and khilafah [inheritance of authority]. This is noteworthy that journey of khalafah and tamkeen fin ‘ard begins with da‘wah [preaching towards deen] and passing through various milestones ends up again at da‘wah, as obvious from ayat-ul-istakhlaf quoted above. Therefore, the seekers of khilafah and tamkeen fil ‘ard should strive hard and keep struggling with the work of da‘wah with dedication in all circumstances and all means as per time and place requirements in lined with the modus operandi of Prophets, particularly Prophet Muhammad (s.a.w), instead of awaiting the status of khilafah and tamkeen fil ‘ard as prerequisite to start with the work of da‘wah and establishment of deen. This paper primarily aims to elaborate the milestones of Muslim Ummah to reach to the status of khilafah and tamkeen fil ‘ard. It also cast light on the objectives of khilafah and tamkeen fil ‘ard. This work provides useful guidance to Muslim Ummah in general and Ahlud da‘wah in particular about milestones and objectives of khilafah and tamkeen fil ‘ard.
Hepatitis C is a major health problem affecting more than 200 million individuals in World including Pakistan. Current treatment regimen consisting of interferon alpha and ribavirin does not always succeed to eliminate virus completely from the patient’s body. The mechanism how Hepatitis C Virus (HCV) induces interferon resistance is still indefinable. HCV genotype 1a shows greater hindrance to treatment than genotype 3a. One of the mechanisms by which virus evades the antiviral effect of interferon alpha involves that HCV envelope protein 2 (E2) interacts with Protein Kinase (PKR) which is the interferon-inducible protein kinase and which in turn blocks the activity of its target molecule called eukaryotic translation initiation factor 2 alpha (eIF2α). Sequence analysis of Envelope protein reveals it contains a domain homologous to phosphorylation sites of PKR and the translation initiation factor eIF2alpha. This domain is known as protein kinase (PKR) eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation homology domain (PePHD). This domain in HCV genotype 1 strains is reportedly homologous to PKR and its target eIF2α. Thus envelope protein competes for phosphorylation with PKR. By binding to PKR, PePHD inhibits its activity and therefore cause virus to evade antiviral activity of interferon (IFN). In the present study the possible role of phosphorylation in envelope 2 protein for interferon resistance was first investigated in silico and then confirmed invivo. Genes coding for envelope 2 protein were isolated from local HCV isolates and their tertiary structure was predicted. Insilico phosphorylation of tertiary structures revealed that two residues S75 and S277 of envelope 2 gene are surface exposed at cytoplasmic domain and may compete with the phosphorylation of PKR protein. Interferon induced antiviral protein PKR has a role in the HCV treatment as dsRNA activated PKR has the capacity to phosphorylate the serine and threonine of E2 protein and dimerization of viral RNA. E2 gene of HCV genotype 1 has an active role in IFN resistance. E2 protein inhibits and terminates the kinase activity of PKR by blocking it in protein synthesis and cell growth. This brings forward a possible relation of E2 and PKR through a mechanism via which HCV evades the antiviral effect of IFN. A hybrid in-silico and wet laboratory approach of motif prediction, evolutionary and structural analysis has pointed out serine 75 and 277 of the HCV E2 gene as a promising candidate for the serine phosphorylation. It is proposed that Serine phosphorylation of HCV E2 gene has a significant role in interferon resistance. In present study we mutated the two Serineresidues at positions S75 and S277 and their efficacy was checked in respect to interferon resistance. The results of this study suggest that serine residues as predicted have a significant role in interferon resistance, especially S75. It is also suggested that some other factors may be involved along with viral envelope gene 2.