حکیم صدیق احمد امروہوی ثم بریلوی
مئی کے اسی ہفتہ میں ایک اورحادثہ یہ پیش آیا کہ ہمارے نہایت عزیز اور مخلص دوست اوراپنے فن کے ماہرحکیم صدیق احمد صاحب امروہوی ثم بریلوی نے وفات پائی۔عمرغالباًپچھتر چھہتر برس ہوگی۔اصل وطن امروہہ ضلع مرادآباد تھا، مگر ایک عرصۂ دراز سے بریلی میں مقیم تھے۔ ان کے والد ماجد مولانا حکیم مختار احمد صاحب ایک نہایت حاذق طبیب ہونے کے علاوہ پختہ استعداد کے عالم باعمل، متقی اور عابد و زاہد بزر گ تھے۔ حکیم صدیق احمد کی بھی علوم وفنون میں استعداد بڑی پختہ تھی، شروع میں منطق اورفلسفہ کا بڑاغلبہ رہا۔نہایت ذہین اور طباع تھے۔اس لیے کوئی موضوع بحث ہو تقریر مدلل اورمنطقیانہ کرتے تھے۔ حضرت شاہ عبدالقادر صاحب رائے پوری سے بیعت ہونے کے علاوہ اعمال و وظائف کا ورد کثرت سے کرنے لگے تھے۔فن طب میں نظری اورعملی مہارت و حذاقت انھیں ورثہ میں ملی تھی، طبیعت بے حد رساتھی۔تشخیص اورتجویز دونوں میں ان کی شہرت دور دور تک تھی۔ سینکڑوں بڑے معرکے کے علاج کئے لیکن وہ جتنے بڑے طبیب تھے، اسی قدر مزاج سخت لاابالی اورروپیہ پیسہ کے لالچ سے کوسوں دورتھے۔ غریبوں اور ضرورت مندوں کی امداد اپنی جیب سے کرتے تھے اورعلما کی خدمت کرکے خوش ہوتے تھے، غرض کہ بڑی خوبیوں اورکمالات کے انسان تھے۔اُن کے پاس مخطوطات کاایک خاصہ ذخیرہ تھا جس میں حضرت مولانا محمد قاسم صاحب نانوتوی اوربعض دوسرے بزرگوں کے مکاتیب اور ان کی تحریریں شامل ہیں۔لیکن راقم الحروف کے سخت اصرار کے باوجود انھوں نے ان چیزوں کو نہ خود چھاپا اورنہ کسی اورکو انھیں نقل کرنے کی اجازت دی۔پھر معلوم نہیں ان کا کیا حشر ہوا۔
اخلاق وعادات کے اعتبار سے نہایت خلیق،خوش طبع و خوش مزاج اور متواضع و مہمان نواز تھے۔رحمہ اﷲ رحمۃً واسعۃً۔ [جون۱۹۷۸ء]
اسلامی تہذیب میں تازہ کاری کی روایت: قرون اولی کا اختصاصی مطالعہ Islamic civilization was founded by the Holy Prophet (May blessings of Allah and peace be upon him) right from the beginning of Islam. Each civilization and every culture are deeply affected by the concurrent cultures and civilizations and it used to adopt and borrow many things from other civilizations. Similarly, Islamic civilization and culture borrowed many aspects from other prevailing civilizations. With the passing day, these intercultural relations and exchanges became the part and parcel of the Islamic civilization. Such communications, and they have marked all epochs in Islamic history, occur in greatly diverse ways. The Holy Prophet also approved some traditions in this regard and the four Caliphs adopted many customs too. This reflects the adoption and concluding from other civilizations is not prohibited in every case, but this adoption must not be against Islamic teachings. Now a days, the entire world has become a worldwide town because of internet and technological developments. It is relatively obvious that Muslims are adopting many things from western civilization and culture without knowing its legitimacy or illegitimacy. Resultantly, these activities apparently become the chunk of Islamic civilization. This investigation seeks guidance from golden period of Islam i.e. Early centuries of Islam and describes its validity or voidness. In this article, these experiences of Islamic civilization and culture in adopting and concluding from other civilizations and cultures have been conferred and their principles and opinion of the prominent scholars, in this context, been talked about in the light of Islamic teachings. This study will promulgate awareness about the tradition of innovation in Islamic civilization and will provide guidance to the new researchers about this topic.
A combinatorial synthesis of small libraries of a variety of amino chalcones has been carried out in solution phase under standard Claisen Schmidt conditions. The compounds were tested for their potential as antibacterial and cytotoxic agents as well as phosphatase inhibitors and the leads were identified in each bioassay. Chalcone 7 was found to have strongest potential as cytotoxic agent, while chalcone 11 be the most potent PGM inhibitory agent. Parallel synthesis of a 120 member chalcone library was carried out as mixture synthesis following the positional scanning protocol. The identification of lead in this library was carried out by deconvulution and chalcones 22 and 41 were found to be the most potential candidates to be developed as antibacterial agents. Following the same strategy of mixture synthesis, another 175 member chalcones library was synthesized and most potent anticancer chalcones 31, 61 and 78 were identified by deconvolution through position scanning protocol. Peptidyl α,β- unsaturated ketones were synthesized as novel bis- electrophiles susceptible for 3+2 and 3+4 annulations. As a result, peptidyl oxazoles, pyrazolines, pyrazoles, benzothiazepines and benzodiazepines were synthesized. Potent antidiabetic chalcones were docked into the PGM active site and a rationale was found for greater antidiabetic activity of chalcones over the other. Rational design and synthesis of some cytotoxic chalcones was based on 3DQSAR studies using CoMFA as a tool. 3DQSAR studies were also carried out on a library of 30 chalcones as potential antitumor agents.