ڈاکٹر عادل صدیقی
ڈاکٹر عادل صدیقی(۱۹۵۴ء پ) کا اصل نام محمد شبیر صدیقی ہے۔ آپ چوہان برہانپور پسرور میں پیدا ہوئے۔ ۱۹۸۷ء میں بطور لیکچرار مرے کالج سیالکوٹ میں اپنے فرائض سنبھالے اور بعد میں پنجابی ادب میں پی ایچ ڈی کی۔ (۱۰۸۴) عادل صدیقی کی شاعری جدید رجحانات کی عکاس ہے۔ وہ اردو اور پنجابی میں بڑی مہارت سے شعر کہتے ہیں۔ اردو میں عادل صدیقی کا پہلا شعری مجموعہ ’’نوید موسم دل‘‘ شائع ہو چکا ہے۔ دوسرا شعری مجموعہ ’’غزل تم سے عبارت ہے‘‘ سنگت پبلی کیشنز لاہور نے ۲۰۰۷ء میں طبع کیا۔ حقیقت پسندی، امن و آتشی ، بھائی چارہ ،انسانی ہمدردی اور پیارو محبت عادل صدیقی کی اردو شاعری کے اہم موضوعات ہیں ۔نمونہ کلام ملاحظہ ہو:
جسم ہے پھول اگر، روح کو خوشبو سمجھو
بُو اڑی گل سے تو رنگت کے سوا کچھ بھی نہیں(۱۰۸۵)
کاش پھر شاخِ تمنا پہ ثمر آجائے
ختم ہو تیرہ شبی اور سحر آجائے
آبلے پا ئوں کے فریاد بلب ہیں عادل
اب تو خوشبو کا جہاں پیار نگر آجائے
(۱۰۸۶)
جب سے انسان نے رکھا ہے قدم دنیا میں
تب سے وابستہ ہوئے رنج و الم دنیا میں
پھول تقسیم کریں اپنے لیے خار چنیں
ایسے انساں نظر آتے ہیں کم دنیا میں
اپنے افعال سے دنیا ہے جہنم عادلؔ
اپنے کردار سے ملتی ہے ارم دنیا میں
(۱۰۸۷)
In contemporary world several efforts have been made to restore the global peace, harmony and co-existence, and still the struggles continue but in vain. There are some serious problems to be addressed in the first phase. Some of these problems, for interfaith harmony and co-existence are associated with political and economical imbalance or injustice, while some of these are related to social and collective values at the world level, particularly in the Muslim society. In the past, political and economic motives were responsible for wars. It is predicted that in future the situation will remain the same. However Religious extremism and fundamentalism are just slogans of the western world for covring up real economic intentions. Western world particularly Americans promote wars for achievement of economic gains. This article focuses on the real causes of terrorisim, which is threatening our globe. Moreover it also suggests how to control these issues and help in the restoration of peace and interfaith harmony. The economic, political and social causes have been highlighted in detail. The big powers while talking of helping the developing countries want in reality to exploit economically those countries.
In the present study, 52 different homoleptic and heteroleptic Pd(II) complexes were synthesized by reacting palladium(II) chloride with substituted triphenylphosphine and sodium salts of dithiocarbamates namely in a mixture of dry solvents. The ligands and various substituted triphenylphosphines used were sodium 4-benzylpiperazine-1-carbodithioate (L-1), sodium 4-diphenylmethylpiperazine-1-carbodithioate (L-2), sodium 4-(2-methoxyphenyl)piperazine-1-carbodithioate (L-3), sodium 4-(3-methoxyphenyl)piperazine-1-carbodithioate (L-4), sodium 4-benzylpiperidine-1-carbodithioate (L-5), sodium 4-(2-pyridyl)piperazine-1-carbodithioate (L-6), sodium 4-(2-pyrimidyl)piperazine-1-carbodithioate (L-7), sodium 4-(2-furoyl) piperazine-1-carbodithioate (L-8), sodium 4,4''-trimethylenedipiperidine-1-carbodithioate (L-9), tris(p-chlorophenyl)phosphine, tri-p-tolylphosphine, diphenyl-p-tolylphosphine, 1,4- bis(diphenylphosphino)butane, and tris(4-flourophenyl)phosphine. The coordination mode of ligands toward Pd(II), structural confirmation and geometry assignment of the complexes were made, using different analytical techniques such as elemental analysis, FT-IR, multinuclear (1H, 13C and 31P) NMR and X-ray single crystal analysis. Based on results, the ligand appeared to coordinate the Pd(II) atom through CSS moiety. The homoleptic and heteroleptic Pd(II) complexes demonstrate perfect square planner and distorted square planer geometries, respectively. The synthesized complexes were screened for in vitro cytotoxic activity against six different cell lines, LU (Lungs cancer cell lines), MCF-7 (mammary adenocarcinoma cell), 1c1c7 (murine hepatoma cells), PC-3 (prostate carcinoma), MDA-231 (estrogen-independent breast cancer cells) and HeLa (cervical carcinoma cell) by the MTT {Tetrazolium [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} method. The homoleptic Pd(II) was less active whereas heteroleptic Pd(II) complexes composed of bidentate 1,4-bis(diphenylphoshino)butane, flouro and uncoordinated group (carbonyl and nitrogen) was found to be most active against different cancer cell lines as compare to the standard drug (Staurosporine and cisplatine). The interaction of the selected Pd(II) compounds with DNA was investigated by UV-Vis spectroscopy. The hypochromic effect for all the selected Pd(II) complexes was observed, indicating intercalative mode of interaction of these complexes with DNA. The antioxidant activity of selected Pd(II) complexes were evaluated using DPPH as a free radical and Ascorbic acid as a standard. Most of the complexes showed higher antioxidant property than the standard. The selected Pd(II) complexes were also evaluated to check their cytotoxicity and phytotoxicity using brine shrimp assay and seedling growth of maize, respectively. The highest activity was shown by compounds containing oxygenated species (19). Selected complexes were also screened for their antibacterial and antifungal activities against various strains of bacteria and fungi, and were found active.