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Analysis of Superoxide Dismutase and its Subcellular Regulative Factors in Stroke Patients

Thesis Info

Author

Misbah Irfan

Department

Department of Biochemistry, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Page

x, 72,

Subject

Biochemistry

Language

English

Other

Call No: DISS/M.Phil. BIO/3092

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676717015779

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مولوی ریاض حسن خان خیالؔ

مولوی ریاض حسن خان خیالؔ
افسوس ہے کہ گذشتہ مہینہ مظفر پور بہار کے مشہور صاحب علم اور علم دوست رئیس مولوی ریاض حسن خان خیال نے اُناسی (۷۹) سال کی عمر میں انتقال کیا، وہ اور اُن کے بڑے بھائی مولوی اعجاز حسن خان مرحوم قدیم مشرقی تہذیب و شرافت اور قدامت و وضعداری کا نمونہ تھے اﷲ تعالیٰ نے ان کو دولت دنیا کے ساتھ علم کی دولت سے بھی نوازا تھا اُن کا خاندان صوبہ بہار کے تاریخی اور صاحب وجاہت خاندان میں تھا، دونوں بھائی صاحب علم و نظر اور وسعتِ معلومات کے لحاظ سے زندہ کتب خانہ تھے، اعجاز حسن خان مرحوم کے مضامین الندوہ اور معارف وغیرہ میں نکلتے رہتے تھے، اس علمی ذوق کی بنا پر اُن کے بہت سے ہم عصر اصحاب علم و کمال سے اُن کے تعلقات تھے، مولانا شبلی مرحوم کے خاص دوستوں میں تھے، مکاتیب شبلی میں ریاض حسن خان کے نام کے بہت سے خطوط ہیں، مولانا مرحوم جب پٹنہ جاتے تو انہی کے مہمان ہوتے تھے، اس سلسلہ میں ایک ادبی لطیفہ قابل ذکر ہے۔
ایک مرتبہ مولانا ان کے مہمان تھے، ریاض حسن خان کی طبیعت کچھ نا ساز تھی، وہ دوسرے کمرے میں تھے، مولانا جب اُن کی مزاج پرسی کے لیے پردہ اُٹھا کر کمرہ میں داخل ہوئے تو ریاض حسن خان احتراماً اٹھ کر بیٹھ گئے، مولانا نے فرمایا آپ بیمار ہیں تکلف نہ کیجئے لیٹے رہئے، ریاض حسن خان نے اس کے جواب میں مولانا کا یہ شعر پڑھ دیا۔
باہمہ دعویٰ تمکین نتوان خواست زمن
کہ تو از پردہ بدر آئی و بر جا ہاشم
یہ برجستہ جواب سُن کر مولانا بہت محظوظ ہوئے اعجاز حسن خان مرحوم کا انتقال فروری ۱۹۳۹؁ء میں ہوا تھا، ۱۴ سال کے بعد چھوٹے بھائی بھی بڑے بھائی سے جاملے، وہ...

PENDIDIKAN IPS BERBASIS KEARIFAN LOKAL DENGAN PENDEKATAN ETNOPEDAGOGY DITINJAU DARI PRESPEKTIF KURIKULUM

The personal social issues experienced by students in daily life are important studies in social studies education. The study of the role of the environment is very important in preserving local wisdom that is beginning to be abandoned by the younger generation, especially the students as a generation of gold who will continue the eastafet stick of development. The importance of a learning approach that is relevant to the situation of students, learning in accordance with the real world reality of students with ecological intelligence (Ekopedagogy) by exploring local wisdom that can be developed through social studies with the selection of contextual material, and meaningful for students to develop skills concern for the community, and place empathy as a form of positive attitudes towards environmental conservation based on local wisdom through the ecopedagogy approach. Keywords: social studies, local wisdom, ethnopedagogy

Integrated Strategies for the Control and Prevention of Dengue and Malarial Vectors.

Mosquitoes are vectors of many life-threatening human diseases. In the absence of vaccine and treatment for most of these diseases, the only solution is to control mosquitoes by using insecticides. Any significant reduction in mosquito populations effectively lowers disease transmission risk in an area. At present, broad-spectrum synthetic insecticides are widely used in mosquito control especially when disease outbreaks threaten human health. Continuous use of these chemicals sooner or later results in development of resistance in vector species, biological magnification of toxic substances through the food chain, and adverse effects on environmental quality and non-target organisms.In the present study, the emphasis is given on larval mosquito control using plant products (botanicals) mixed with reduced rates of some synthetic insecticides (temephos, deltamethrin, mixture of allethrin and resmethrin, and methoprene) or a microbial control agent (Bacillus thuringiensis israelensis) for obtaining a sustainable and more effective method of mosquito control. Combined use of these insecticidal products may exploit physiological tradeoffs to stop or slow down resistance evolution. Low rates of synthetic chemicals are usually softer to the environment and non-target species. Extracts of many plant species have shown biological activity against mosquitoes and other insects. These compounds are biorational products which are relatively non-toxic to people and exhibit fewer or no sideeffects to the environment. Unfortunately, when used alone plant chemicals are not as efficacious as the other insecticides in mosquito management. In the present study, extracts of fourteen indigenous (medicinal) plant species belonging to eleven families (Amaranthaceae, Apocynaceae, Asteraceae, Cannbaceae, Cucurbitacea, Convolvulaceae, Euphorbiaceae, Gentianaceae, Meliaceae, Solanaceae, Zingiberaceae) were tested against laboratory reared Anopheles and Aedes larvae. Ether, methanol and water were used as solvent for phytochemical extractions. Essential oils were distilled with Soxhlet apparatus. Mixtures of plant extracts with B. thuringiensis israelensis (Bti) and synthetic insecticides were evaluated for joint action mainly in terms of toxicological effect. For all bioassays, the mortality data were collected 2, 4, 8, 16, 32, 64 and 128 hrs. Posttreatment against 2nd and 3rd instar larvae and analyzed using standard statistical procedures including ANOVA and Tukey HSD test.Probit analysis was also used to calculate LC50 and LT50.In the initial trials with plant extracts alone, the highest mortality (70-90%) was obtained with ether extracts and the minimal toxicity (30-65%) was observed with aqueous extracts against both Anopheles and Aedes larvae. Ether extracts of Citrullus colocynthis (L.) produced the highest mortality (88.2%) followed by Datura stramonium L. (86.61%) and Swertia chirayaita (Roxb. ex Fleming) H. Karst. (83.78%). Among the aqueous extracts, D. stramonium L. showed the highest mortality (52.33%). In these trials, all mortality responses were found to be time and concentration dependent. In the mixing trials of plant extracts with chemical insecticides or Bti, most combinations lead to additive and synergistic interactions. Extracts from Azadirachta indica A. Juss, C. colocynthis, D. stramonium, D. wrightii Regel and S. chirayaita mixed with low to moderate rates of synthetic insecticides or Bti produced up to 100% mortality of both Anopheles and Aedes larvae. Among different combinations, the most potent treatments were ether extracts from C. colocynthis, D. stramonium, A. indica (leaves) and S. chirayaita with Bti (LC50: 68 ppm 32 hrs. post-treatment and LT50: 1.04 hrs. at 10% concentration mixture of plant extracts with Bti) and with synthetic insecticides (LC50: 77.7 ppm 32 hrs. post-treatment and LT50: 1.55 hrs. at 10% concentration of mixture of plant extracts with insecticides) against Aedes larvae. In some combinations, mixture contents antagonized effect of each other. Moreover, Anopheles larvae were found to be more susceptible than Aedes larvae. Different outcomes of the mixing trials are probably attributed to individual or combined effects of the ingredients on the insect endocrine system (through enhanced metabolic detoxication). Nevertheless, future studies should explore underlying mechanisms for variance in the joint mortality. In the phytochemical analyses, flavonoids, alkaloids, steroids, tannins, terpenes and anthraquinones were found in different plants used in this study. Among them, flavonoids, steroids and tannins were more common in the promising plant species and hence might have played a role in their toxicity to mosquito larvae. To summarize, the results of this laboratory study indicate that the extracts of indigenous plants C. colocynthis and D. stramonium combined with reduced rate of chemical insecticides or Bti can provide an effective control of mosquito vectors of human diseases such as dengue fever and malaria. Integrated use of these compounds may provide an eco-friendly solution to mosquito management with no or minimal side effects on human health and non-target species. Nevertheless, the use of these mixtures should be further analyzed under the field condition to determine their efficacy and residual activity against mosquito populations and non-target effect in the natural larval habitats.