22. Al-Hajj/The Annual Pilgrimage to Makkah
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
22:01
O The People of the World!
Be conscious of your Rabb - The Lord - in reverence, awe, and piety.
Indeed, the earthquake of the Last Hour is going to be a dreadful thing!
22:02
The Time when you all will see it, every nursing mother will be distracted in dread from whom she is nursing, and
every pregnant female will abort her burden of pregnancy prematurely, and
you will see the people as if they were drunk - gone out of their senses because of ensuing fear, while, in fact, they will not be drunk.
They will have been overwhelmed by the dread of Allah’s intense punishment.
22:03
Even still, some from the people dispute Allah, without any knowledge of HIM,
and follow every defiant Satan - satanic impulse with deviant thoughts.
22:04
It is already been decreed that -
Whoever takes him as an ally, i.e., follows any such Satanic impulse,
he will surely mislead him, and guide him to the punishment of the Blazing Fire.
22:05
O The People of the World!
If you are in any doubt about truth of the Resurrection, then consider the fact that,
WE first created you out of dust/earth - as Adam - and
then as his progeny, out of a small drop of male’s and female’s secretion, then from a clinging thing, and then from a lump, formed and unformed, so that WE may make it clear to you.
WE plant in the womb what WE Please – male or female...
Every single thing made by Allah, the Creator of all things has its own essence of beauty and attraction to it. However, out of all the stunning creations of Almighty Allah, humans are the most superior creation which has the ability to gain knowledge. We, humans, have been given the power by Allah to explore the rest of his creations in nature and fully understand the beauty and functions of each and every aspect of it in order to take advantage of it. Islam is a religion based on nature and Shariah is a law which lays down rules for Muslims to follow which also allows us to move forward with the advancements in the world. It has a unique way of life for any person of any time to follow which cannot be found in any other religion. However, any development which takes place creates new problems and new obstacles which can only be manoeuvred by the researchers and scholars of that specific time who will decide the right use of that commodity and explain the commodity. This will allow the new invention to be utilised fully. Moreover, in this world many people want to look their best and feel their best and will be willing to go through many ways for their ideal look. With this desire, many jobs become associated with achieving this for people. Nonetheless, this leads to people putting their time, money and effort into something which can risk their entire life which can result in either an advantage or disadvantage. Moreover, they should know whether this is against their religious values. Those acts which cross your religious boundaries and are considered “haram”or not permitted are wrong. Thus, it is necessary for us to first consider whether it is crossing the boundaries and proving to be disadvantageous for you so that the wrong norms and values are not transmitted into the future generations.
Hepatitis C is the inflammation of the Liver caused by Hepatitis C virus (HCV), the leading cause of the liver cirrhosis and hepatocellular carcinoma. About 3% of the people have been affected by HCV world wide and in Pakistan being an underdeveloped country; an estimated 10 million people have Hepatitis C infection (WHO). As hepatitis C infection is asymptomatic and due to untimely diagnosis it leads to severe liver diseases and anuualy a lot of affected individuals lose their lives. In order to cure the infection Food and Drug Agency (FDA) has approved the use of Interferon (IFN) as the treatment remedy. In Pakistan National Institute of Health (NIH) has also given the recommendation for the use of IFN as the therapeutic agent In KhyberPakhtunKhwa (KPK) mostly conventional IFN and Ribavirin combination therapy is considered due to the prevalence of responsive genotypes 2 and 3. Earlier no study has been conducted to sort out IFN response among chronic HCV patients in different districts of KPK province, therefore we attempted to find out response of conventional IFN combination therapy at districts level in KPK. Samples were collected from chronic HCV patients referred by clinician/laboratories of different regions of KPK. The samples were analyzed for screening by ICT (Immunochromatographic Technique) and ELISA (Enzyme Linked Immunosorbant Asaay) followed by confirmation through polymerase chain reaction (PCR). We have also done genotyping for some of the chronic HCV patients. PCR confirmed positive patients were given IFN and Ribavirin combination therapy keeping in mind the therapy exclusion criteria. The dose of IFN and Ribavirin was 3 Million Units thrice a week and 800-1200mg daily depending on the age of the patients, respectively. This therapy was continued for six months with repeated testing of ALT (Alanin Transaminase) and CBC (Complete Blood Count), during and after therapy. At the end of six months of therapy, PCR test was done for all course completed patients. Active HCV infection was present in 66.6% among 3075 anti-HCV positive patients while 33.3% anti-HCV positive patients were negative for HCV RNA. Rate of active iiHCV infection was comparatively more in districts Bunir (72%), Dir (70 %) and in Mardan (69%). While lower in districts Swabi (66%), Peshawar (64%) and Kohat (59%). HCV genotype analysis in chronic HCV patients of KPK revealed that the most abundant genotypes/subtypes among the patients analyzed were 2a followed by subtype 3a. Other common genotypes included the untypable type of the virus and genotype 3b. Response of IFN and Ribavirn combination therapy in the 1st trial among 174 PCR positive patients was 74.71% and the resistance was 25.28%. Among different districts, high end of treatment response (ETR) was shown by district Mardan patients population (89.18%), followed by Bunir (69.23%). While low response was present in case of district Peshawar (60%) and Federally Administered Triable Area (FATA) (55.55%). In the second trial of IFN therapy, out of total (341) selected patients for standard IFN- based therapy 81% showed ETR and 19% did not show response. Among the districts high ETR was shown by district Swabi (92%), followed by district Kohat (80%). Comparatively low response was present in case of district Bunir (71%). In genotype specific response of IFN based therapy, out of total 51 selected patients. Responsive genotypes among these were 2a followed by 3a. Response rate among different HCV genotypes were as, 2a HCV genotypes had high (77.72%) ETR, followed by 3a genotypes (72.22%). Comparatively low response was present in case of 3b and 1b genotypes (66.66%) and (33.33%) respectively. While untypable genotypes showed no response. Our results revealed that response of combination IFN therapy is good in some of the districts patients’ population. High ETR rate in these districts may be attributed to prevalence of responsive HCV genotypes 2 and 3. In case of non responsive genotypes some new effective remedies should be discovered. While untypable genotypes should be sequenced so as to adopt some new therapeutic agents against them.