ملا حاجی عبدالرزاق
ایک روشن خیال روشن ضمیر افغانی مصلح عالم کی وفات
اسلامی دنیا میں آج جس چیز کا سب سے زیادہ رونا ہے، وہ ایسے علمائے کاملین کا وجود ہے، جو دین و دنیا دونوں کے علوم و ضروریات پر پوری نظر رکھتے ہوں جو علوم مذہبی اور علوم عصری دونوں کو یکجا تطبیق دینے کے خواہشمند ہوں، جو مذہب اور تمدن کو باہم منطبق کرسکتے ہوں، جو زمانہ حال کی ضروریات کے مطابق احکام مذہبی پر نظر رکھ کر ملک و قوم کی رہبری کا فرض انجام دے سکتے ہوں، جو مساجد کی امامت کے ساتھ صفوف جنگ بھی درست کرسکتے ہوں، جو رموز علمی کے پہلو بہ پہلو نکات سیاسی کو بھی سمجھ سکتے ہوں، ایسے علمائے مصلحین کا وجود کچھ نہ کچھ مصر و ہندوستان و ترکی و روس و تونس میں تو معلوم تھا، مگر افغانستان کی نسبت کسی ایسی مفید مقدس ہستی کا علم نہ تھا۔ امان، افغان کابل مورخہ ۲۴؍ رمضان المبارک ۱۳۴۳ھ سے ابھی اس کا حال معلوم ہوا اور ساتھ ہی وفات کی خبر پڑھی۔
ملا حاجی عبدالرزاق خان افغانستان کے امام وقت اور مشہور مدرس و عالم تھے، ہندوستان میں آخری تعلیم پائی تھی، ان کا سلسلۂ فیض بڑا وسیع تھا، افغانستان کے تمام نوجوان علماء ان کے شاگرد یا شاگرد کے برابر ہیں، ان کا تعلق ایک قدیم علمی خاندان سے تھا، مروجہ اسلامی و مشرقی علوم کے حصول کے بعد وہ ۴۰ سالوں سے درس و تدریس میں مشغول تھے اور آخر وقت تک یہی شغل جاری رہا، اگرچہ وہ تمام فنون میں درس دیا کرتے تھے، لیکن ریاضی، ہئیت اور حدیث میں ان کو کمال تھا، وہ اسلامی تاریخ، جغرافیہ و اخلاقیات میں بھی واقفیت نام رکھتے تھے۔ان علمی مشاغل کے باوجود موجودہ سیاست سے بھی کافی دلچسپی رکھتے تھے اور...
This research is intended to explore the nature of relationship between Islam and Science whether they are compatible with each other or not? By studying and comparing the teachings of Islam and science it has been exposed that both are different in their foundations, nature and scope. Domain of science is limited to the realm of senses whereas Islam provides the knowledge and guidance about materialistic, unseen and metaphysical domain. Foundations of religion are based upon the revelation while science is based upon theories and experiments. Therefore when science reach the reality after passing through trial and error, confirms the teachings of religion, which proves that Islam and science are not only compatible but Islam plays a role of leadership and basic source for the scientific investigations. Moreover after careful review of Islamic and scientific knowledge it is suggested to know the foundations, nature and scope of both to know the relationship between them and to avoid the confusion.
Background Coronary artery disease is one of the leading causes of mortality and morbidity around the world. The Indo-Pak sub-Continent has one of the highest predispositions to Coronary artery disease. Apart from the established risk factors such as diabetes mellitus, hypertension, smoking, alcohol intake, family history, and obesity that played an important role in the development of CAD, genetic polymorphism also emerge as a risk factor in the incidence of Coronary artery disease. Thrombomodulin (THBD) gene is one of them. It is a transmembrane protein expressed on the surface of endothelial cells. It is an important vasoprotective and thromboresistant substance. This natural anticoagulant abates thrombin’s activity and activates Protein C. The relationship between Thrombomodulin gene polymorphisms and coronary disease remains Controversial. It has been reported that a single nucleotide polymorphism (CT) at position 1418 of thrombomodulin gene results in amino acid change from alanine (A) to valine (V) at protein position 455 of TM gene (Ala 455 Val). A considerable number of studies conducted across the globe showed a varied relationship between TM gene polymorphism and coronary artery disease. Therefore the aim of the present study is to assess the association between TM gene Polymorphism and coronary artery disease in general adult Population of Karachi, Pakistan ii METHODOLOGY This is a case control study that was conducted in Tabba Heart Institute in association with National Institute of Blood Disease, Karachi. In this study we explore the association between C/T dimorphism that might predict as a risk factor for coronary artery disease in population of Karachi. We compared C/T dimorphism in 92 cases with 90 control subjects by allele specific amplification. RESULTS The frequency of CC, CT and TT genotype was 81 (90 %), 6 (6.7%) 3 (3.3%) in controls and 67 (72.8%), 20 (21.7%) and 5 (5.4%) in cases respectively. In case group the CT/TT genotype were found to be significantly associated with coronary artery diseases when compared with control group (p-value 0.009). Both cases and control were in Hardy Weinberg equilibrium (HWE), i.e. for cases HWE was (X2 = 3.81, p>0.05) and for controls HWE was (X2 = 19.4, p>0.05). CONCLUSION TM C1418T polymorphism appears as a risk marker in Coronary Artery Disease patients in the population of Karachi, Pakistan.