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In Silico Integrative Approach to Identify Druggable Candidates in Klebsiella Pneumoniae: A Multi-Drug Resistant Pathogen

Thesis Info

Author

Noor-Ul-Ain Sajid Mughal

Supervisor

Syed Sikander Azam

Department

National Center for Bioinformatics, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Page

ix, 68

Subject

Bioinformatics

Language

English

Other

Call No: DISS / M.PHIL / BIO/ 4224

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676717812598

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سلطان کھاروی دی حیاتی

سلطان کھاروی دی حیاتی

جنم

سلطان کھار وی 1965ء نوں پنڈ کھارا ضلع گوجرانوالاوچ پیدا ہوئے ۔

خاندانی پچھوکڑ

ساڈا پیارا دیس جیہدا ناں چوہدری رحمت علی نے رکھیا جیہدا سفنا علامہ اقبال نے ویکھیا تے جینہوں وجود وچ لیائون لئی قائد اعظم محمد علی جناح نے اپنیاں نیندراں دی قربانی دتی ۔ پاکستان تے بن گیا پر ظلم ایہہ ہویا جے پنجاب وچ لکیر مار دتی گئی ۔پنجاب د و ٹوٹے ہو گیا۔اک مشرقی تے اک مغربی پنجاب، جیہدے وچ اسیں تسیں رہندے آں ۔مشرقی پنجاب دے  مشہو ر ضلعے جالندھردے پنڈ تلوں دے نیڑے تیڑے ایہہ پنڈ اج وی موجود اے ۔ اوس پنڈ دا ناں اے کوٹ بادل خاں ۔بادل خاں کوئی سر کڈھ پٹھان سی جیہدی قبر اج وی کوٹ بادل خاں وچ موجود اے ۔ایس کوٹ بادل خاں توں 1947ء دی ونڈ مگروں اک خاندان ہجرت کر کے پاکستا ن آ یا ۔خاندان دے وڈے داناں سی (چوہدری بوڑا)جیہڑے سلطان کھاروی دے دادا سن ۔ چوہدری بوڑا 1958ء وچ فوت ہو ئے ۔اوہناں نوں کھارے دا نمبر دار بنا دتا گیا سی ۔ اوس سمے جدوں لوکائی اپنے اپنے ساکاں انگاں دی تلاش وچ ایدھر اودھر بھٹکدی پھر دی سی ۔

سلطان کھار وی دا پنڈ کھارا

ضلع شیخوپورہ دے مشہور پنڈ جنڈیا لا شیر خاں توں شمال نوں جائیے تے باراں تیراں کلومیٹر تے اک پنڈ اے ۔جدوں پاکستان بنیا تے ایس پنڈ وچ کوئی سو گھر وی نئیں سی ۔ایس پنڈ دا ناں اے ’’کھارا ‘‘ایہہ پنڈ ضلع گوجرانوالادی حدود وچ اے تے پنڈ کھارا وچ لنگھن والی سڑک سدھی گوجرنوالا دے اعوان چوک نال جا لگدی اے ۔

 

چوہدری بوڑا دی آل اولاد

نسخ القرآن و نسخ کتاب مقدس

Technically, Naskh refers to the abrogation of a religious ruling through another religious ruling involving commands and prohibitions, and, the abrogation being either through a Qur’anic statement, Hadith, or consensus of the Ummah. There can be, and has not been, abrogation of a spiritual matter, moral, historical, exhorting statements, doctrinal, or Allah's attributes. Allah said We do not abrogate a verse, or cause it to be forgotten, but substitute with one better than it or similar to it. Do you not know that Allah has power over everything?” (Al Baqarah: 106). Naskh involves two elements: naasikh (the abrogating one), and mansukh (the abrogated one). This is an important discipline for those who attempt deeper understanding of the Qur’an. There were several points of wisdom behind abrogation in early Islam. For centuries, human societies lived a certain kind of life: closer to beastly than human. Their situation could only be changed gradually. That required allowing certain things in the early stages of change and development, to be disallowed later.

Phosphorus Utilization from Rock Phosphate by Maize Zea Mays L. Through Integrated Organic Manures

Pakistan is a subtropical, semiarid country of 79.61 M ha area, which relies heavily on agricultural production to supply food for its rapidly increasing population of over 135 million. The country is divided into four regions, two of which contain the majority of the flat topographic plains having the bulk of 21 M ha of cultivated land. There are two general cropping seasons in tropical flat plains of Pakistan i.e. Rabi (winter) and Kharif (summer) season. Cotton, maize, rice and wheat are the main crops of Pakistan. Majority of Pakistani soils are calcareous and alkaline with pH in the range 7.5 to 9.5. These soils reduce the availability of P considerably as P is converted to insoluble forms at this pH. Overall, P fertilizer application to Pakistani soils is inadequate. Energy crisis, high prices of phosphatic fertilizers and their shortage at peak crop requirement has become a serious issue in Pakistan. Rock phosphate (RP) has low bio-solubility of about 0.1 % under alkaline conditions if applied directly. Therefore, bio-solubilization RP to release P needs to be boosted up using some innovative approaches. Pakistan by default contains considerable quantity of economical reasonable quality RP in Abbottabad and Haripur districts. However, extensive scientific work is needed so that local rock phosphate may be used for P nutrition. Under this research plan four consecutive experimental units were performed to enhance total and water soluble P content in RP. In the first study, local and imported rock phosphates in combination with different materials of organic nature were applied. The purpose of above research proposal was to explore role of organic materials for P release from local & imported RP and P uptake by maize crop. Maximum solubilization of P was achieved when filter cake press mud (FCP) was applied in combination with rock phosphate. The 2nd study comprised of 7 treatments with three replications. Use of dewaxed filter cake press mud was evaluated as most suitable source of local rock phosphate. Third study of this research proposal comprised of 7 treatments which were replicated thrice. Combined use of FCP with RPR and TSP performed better than their individual use. Use of organic amendment improved soil organic carbon fraction of soil compared to control. The 4th study was conducted in the field using RCBD with five treatments. Exogenous application of FCP along with indigenous Hazara rock phosphate RPR and NK proved as better nutritional source compared to control. Further, application of selected organic manure (dewaxed filter cake press mud) improved soil organic carbon fraction in similar environment condition.