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2-Dimensional Seismic Interpretation of Reflection Data, of Indus Offshore Basin, Pakistan

Thesis Info

Author

Saad Farhad Aslam

Department

Department of Earth Sciences, QAU

Program

MSc

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2010-2012

Thesis Completion Status

Completed

Page

99

Subject

Earth Sciences

Language

English

Other

Call No: DISS/M.Sc. EAR/1245

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676718132735

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حاجی احمد غریب

حاجی احمد غریب
دوسراافسوس ناک سانحہ جولائی میں حاجی احمد غریب صاحب کاہوا۔حاجی صاحب بمبئی کے مشہور صاحب خیر تھے۔ ملّی اوراجتماعی کاموں میں بڑھ چڑھ کر حصہ لیتے تھے، اعلیٰ درجہ کے منتظم تھے۔ حجاج کی خدمت سے عشق تھا، بمبئی کی انجمن خدام النبی کے روح رواں تھے۔ صابو صدیق کامسافر خانہ کاانتظام بھی ان ہی کے ہاتھ میں تھا۔ ابھی چندسال ہوئے اس تاریخی مسافرخانہ کی اوپر کی منزل بڑے اہتمام سے تعمیرکرائی تھی۔جمعیۃ العلماء ہند کے زیر اہتمام۱۹۵۴ء میں جو دینی تعلیمی کنونشن بمبئی میں ہواتھااس کا اہتمام بھی مرحوم ہی نے کیا تھا۔
ندوۃ المصنفین سے بھی خاص تعلق رکھتے تھے اوراس کی خدمات کی قدر کرتے تھے۔ ایک سال سے زیادہوا کہ کراچی چلے گئے تھے، وہیں۱۴/جولائی کو اچانک دل کادورہ ہوا اورجاں بحق ہوگئے۔ اﷲ تعالیٰ مرحوم کی مغفرت فرمائے اوران کے نیک دل بھائی حافظ محمد صدیق صاحب حجازی اورتمام متعلقین کودولت صبر سے نوازے۔ [ستمبر۱۹۶۷ء]

 

The Origin and Evolution of Sufism

The early Sufis believed that there were two dimensions to the revelations received by the Prophet, words of the Qur’an in their appearance, and the divine inspiration in his heart. This divinely inspired knowledge in the heart, Sufis claim, was gifted to only a chosen few, who contemplated and longedfor nearness with the creator. The early Sufis also laid emphasis on one of the basic tenets of Islam i. e. ihsan. Ihsan is that level of devotion where the devotee is completely absorbed in the worship of God. The ultimate aim of the Sufis is to raise the level of ihsan to experience the presence ofGod. Since the Last Prophet (s. a. w.) was paragon of virtues including ihsan, it was assumed that Sufism or Tasawwuf originatedfrom the Prophet himself. This paper aims to focus on the point of origin of tasawwuf, on the one hand and the need for its revival, on the other.

Designing and Fabrication of Microfluidic Device for Therapeutic Drug Monitoring

Cardiovascular diseases are one of the leading causes of mortality in Pakistan with prevalence rate of 19 %. Digoxin, a cardiac glycoside with positive inotropic effect is most commonly prescribed to cardiac patients; involving therapeutic monitoring of drug in serum/plasma through lengthy immunoassay procedures in practice. Also, the detection facility is restricted to private labs in major cities of Pakistan. Nanotechnology with the help of nanomaterials as compared to conventional lengthy procedures offers robust, patient centered on chip methodologies for detection of therapeutically important drugs in serum/plasma. The aim of the current study was fabrication of microfluidic device offering on chip QDs based detection of clinical range of digoxin (0.8-2.0 ng per ml) in custom-made optical setup. To achieve the said objectives, sequence of experiments were conducted. It was imperative to delineate the effect of pH of media on the fluorescence of zinc sulphide (ZnS). ZnS nanowires were conjugated with different log dilutions of mercaptoacetic acid (MAA) and digoxin antibody (Ab). To observe the effect of each dilution on fluorescence of NWs, pH of the media was monitored before conjugation. This study highlights the enhancement in PL of ZnS NWs when pH of the media is almost equal to the pKa of carboxyl group of MAA (pH ~ pKa). While, quenching in fluorescence was observed when pKa < pH> pKa. Thus, proving our hypothesis of use of ZnS as a fluorescent tag for biological applications. The effect of pH, ions in media and time of incubation on the PL of MAA coated QDs was studied by incubating dots in three different phosphate buffers. The pH of media for each buffer was adjusted as acidic (pH <7.2), neutral (7.2 - 8.0) and basic (pH> 14.0).The PL response from dots in buffer 1 was more profound as compared to other two buffers. The current study demonstrated maximum fluorescence from dots in buffer 1 within pH range of 7.0 – 10.0, which increases with increasing time of incubation.Electrochemical analysis was performed to study the mechanism of electron transfer from QDs to linker (MAA) and then to Ab using electrochemical analysis. Electrochemical analysis shows resistance in electron transfer when electrode was modified with QDs and Ab conjugated QDs (QD-MAA-Ab) as compared to when modified with MAA only. The number of electrons calculated during the oxidation or anodic cycle were: 2, 1,3 and 4 for GCE, QD, QD-MAA and QD-Ab, respectively. During the reduction or cathodic cycle, the electrons found were 2, 1,4 and 6 for GCE, QD, QD-MAA and QD-Ab. Finally, detection of different log dilutions of digoxin inclusive of the therapeutic range (0.8-2.0 ng/ml) spiked in PBS buffer (1ml) using emission (quantum dots (QD)) and plasmon based (gold nanoparticles (SERS)) methods. Limit of detection (LOD) achievable through emission-based methodology was 0.5 ng/ml while 0.4 ng/ml through plasmon resonance of gold nanoparticles. Then the emission-based detection was performed in fabricated microfluidic device using homemade optical detection setup. The fabricated device is of ((H x W x D) 2.7’’ x 0.98” x 0.005)) as compared to conventional digoxin detection machine (Architect i2000SR: (H x W x D) 48’’ x 61” x 49”). The current study envisages replacement of conventional methodologies with microfluidic device or chip using quantum dots and SERs based tags as compared to conventional enzyme-based labels. The said device would be cost effective, portable and can easily be carried to remote areas of country.