مخطوطات السيرة النبوية في الجامعات الباكستانية فى القرن العشرين

Allah Almighty has kept many sources to save his eternal message, of writings the in biography holy his and صلى الله عليه وسلم prophet his of words golden the different scholars. This shows the importance of our sacred heritage that includes the biography of the Holy Prophet ﷺ. These hand-written books (manuscripts) consist of the exegesis of Qur’ān, Jurisprudence, Principles of Exegesis of Qur’ān and Jurisprudence, morphology, syntactic and many other sciences related to Arabic language and literature. The researcher has صلى الله عليه وسلم Prophet Holy the of biography the about manuscripts the evaluated written in different universities of Pakistan during MA, MPhil, and PhD in the 20th century. The research methodology followed in the research is descriptive. Each understudy manuscript is considered from different aspects that include different features of the work done, i. E. Language of the manuscripts, details of the original text, references of Aḥādīth, pattern of footnotes, primary and secondary sources etc. The article is divided into three main sections in the following way: First deals with Islamic Arabic Manuscripts, Second are Manuscripts in Pakistani Libraries and third are would research The. صلى الله عليه وسلم Prophet the of Sirah about Manuscripts evaluated highlight value of the Manuscripts and the critical analysis of the mistakes found in Manuscripts and it would certainly improve their language, and research pattern.

Phytochemical Investigation on the Chemical Constituents of Caralluma Flava

The research work embodied in this thesis deals with the isolation of chemical constituents from the Omani plant named Caralluma flava (N.E.Br) Meve & Liede along with the spectral characterization, biological activities and computational studies. Crude crystals (CR) obtained from the squeezed sap of succulent C. flava showed significant anticancer activity against MDA-MB-231 breast cancer cells and provided nine new pregnane glycosides namely Desmiflavaside A (1), Desmiflavaside B (2), Desmiflavaside C (3), Desmiflavaside D (4), Nizwaside (5), Desflavaside A (6), Desflavaside B (7), Desflavaside C (8) and Desflavaside D (9). The structures of these isolates were elucidated through spectral analysis using UV, IR, HRSEIMS, NMR and by comparing with literature reports. Treatment of MDA-MB-231 breast cancer and SKOV-3 ovarian cancer cells with compounds 3-5 demonstrated a prominent reduction in the viability of both types of cancer cells. Furthermore, 3-5 were also tested for their effect on normal breast epithelial cells (MCF-10-2A) which displayed no significant cytotoxicity on normal cells. The molecular docking studies of 3-5 revealed that these molecules have a good potential to bind with the target protein tyrosine phosphatase. The methanolic extract (ME) of squeezed residual plant and its different fractions also showed good anticancer activity against MDA-MB-231 cells. Different fractions of ME, CR and compounds (1-5) were additionally evaluated for enzyme inhibition (urease, acetylcholinesterase and α-glucosidase) and DPPH antioxidant activities which displayed no remarkable results. The research work embodied in this dissertation has resulted four publications as mentioned in the end of the thesis.