شیخ عبداﷲ
کشمیر کی گل پوشی وادی کے شیر شیخ عبداﷲ اس دارفانی سے کوچ کرکے اب وہاں ہیں جہاں ایک روز سب کو جاکر بارگاہ ایزدی میں اپنا اپنا اعمال نامہ پیش کرنا ہے، اﷲ تعالیٰ ان کو اپنی رحمت بے پایاں سے سرفراز فرمائیں، آمین۔
نجی مجلسوں میں اکثر یہ گفتگو رہتی ہے کہ ہندوستان میں انیسویں صدی میں جتنی عظیم اور قدر آور شخصیتیں پیدا ہوئیں، اتنی بیسویں صدی میں نہ ہوسکیں، مگر اس صدی میں جو چند عظیم المرتبت شخصیتیں پیدا ہوئیں، ان میں شیخ عبداﷲ بھی تھے، ان کی زندگی شروع سے فعال، متحرک اور ہنگامہ پرور رہی، اپنی جوانی میں مہاراجہ کشمیر کی استبدادیت سے ٹکرلی اور جیل گئے، پاکستان کی تحریک اور اس کے قیام کے بعد محمد علی جناح سے بھی تصادم مول لیا، ۱۹۴۷ء کے بعد کشمیر کا الحاق ہندوستان سے کرکے اپنے سیکولرزم کا ثبوت دیا، اور پاکستان سے جنگ بھی کی، لیکن پھر کشمیر کی مخصوص حیثیت کی خاطر، اپنے دوست پنڈت جواہر لال نہرو سے بھی ان کی وزارت عظمٰی کے زمانہ میں سیاسی اور دستوری نبرد آزمائی کی جس کے نتیجہ میں اپنی جوانی کے بہترین ایام قید اور نظربندی کی صورتوں میں گزارے، حکومت ہند سے ان کی معرکہ آرائی الف لیلیٰ کی داستان سے کم نہیں، جھپٹے، پلٹے، پلٹ کر جھپٹے، چھپٹ کر پلٹے، کشمیر کے عوام کے استصواب رائے، حق خود اختیاری اور سرزمین کشمیر کی آزادی کے نعرے بلند کرتے رہے، مگر جب یہ فضا میں صرف گونج کررہ گئے، تو پھر حکومت سے مصالحت کرلی، کشمیر کے وزیراعظم تو نہیں، لیکن وزیراعلیٰ بن گئے، اور اسی حیثیت سے ان کی وفات بھی ہوئی، اور جنازہ بھی اٹھا، جس کے بے پناہ ہجوم سے کشمیر میں ان کی محبوبیت کا اندازہ ہوا۔
وزیراعلیٰ کی حیثیت سے ان کا زریں...
This Paper analyses the causes of the domestic violence against female beggars and their impacts on their lives. The paper is strictly limited to Taluka Qasimabad, District Hyderabad. The domestic violence against women exits in various forms. However, it is pretty horrible in the form being inflicted against female beggars in Qasimabad. The scores of causes for the domestic violence against female beggars range from rising poverty to population explosions with deep physical and mental impacts on the sufferers. For data collection qualitative research through Focused Group discussion method has been used through snow ball technique. 10 Cases of female beggars have been opted for the FGDs out of which two participated with their social backgrounds. The study concludes the pathetic condition of the female beggars due to multiple factors and their serious implications both physically as well as mentally. The study recommends prompt action from the Government as well as social scientist to go deep further in the social issues such as violence against the female beggars. Simultaneously there is immediate intervention of Government and the concerned department to address these issues on emergent basis as the number is likely to reach an alarming level.
Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed non-Hodgkin’s lymphoma in adults worldwide. In Kenya DLBCL accounts for 64% of all non-Hodgkin’s lymphomas diagnosed in adults. It is a heterogeneous disease and patients show varying outcomes despite standard treatment. This variability is attributed to the differences in the biology and molecular pathogenesis of DLBCL. The five most important prognostic factors for DLBCL include scores for the revised international prognostic index (R-IPI), the cell of origin (COO), presence of myelocytomatosis (MYC) and B-cell lymphoma 2 (BCL2) gene rearrangements by fluorescent in situ hybridisation (FISH) or standard cytogenetics, the absolute lymphocyte and monocyte count, and imaging with positron emission tomography (PET scan). Current data shows that the use of immunohistochemistry in identifying cases of DLBCL with MYC and BCL2 protein over-expression (double-expressing lymphomas) yields important prognostic information since these patients form a higher proportion of cases compared to those with concurrent MYC and BCL2 translocations (double-hit lymphomas) using FISH/cytogenetics . The double expressing DLBCL have a poorer prognosis compared to cases of DLBCL lacking MYC/BCL2 double-expression. With advances in targeted therapy for DLBCL, it is important to also identify patients who may benefit from new regimens by determining their cell of origin. Gene expression profiling (GEP), the technique for determining the COO is not available to the routine diagnostic laboratory. Consequently, robust immunohistochemistry surrogates have been developed in place of GEP for this purpose. Hans’ algorithm which uses three antibodies in sequence (CD10, BCL6 and MUM1) is the most widely applied for determining COO. The World Health Organization (WHO) guidelines currently recommend definition of the cell of origin and testing for double MYC/BCL2 expression for every patient diagnosed with diffuse large B cell lymphoma. Furthermore, in order to establish a diagnosis of DLBCL, NOS with certainty, other high-grade B-cell lymphomas, such as Burkitt lymphoma and plasmablastic lymphoma, need to be excluded. This can be achieved by a comprehensive antibody panel that includes MYC and BCL2. These antibodies need to be optimised and standardised for the settings in which a particular laboratory operates. Objectives: To determine the prevalence of MYC/BCL2 double-expression among diffuse large B cell lymphomas diagnosed at The Aga Khan University Hospital, Nairobi (AKUH, N) Laboratory. To define the cell of origin of DLBCL diagnosed at AKUH, N laboratory. Methods: Formalin fixed Paraffin embedded (FFPE) blocks of DLBCL cases diagnosed between January 1st 2012 and December 31st 2015