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Mapping and Dna Sequence Analysis of Hereditary Hearing Impairment Candidate Genes

Thesis Info

Author

Sajid Mansoor

Department

Deptt. of Biochemistry, QAU.

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2008

Thesis Completion Status

Completed

Page

vii,43

Subject

Biochemistry

Language

English

Other

Call No: DISS/M.Phil BIO/2138

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676718368016

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اردو زبان کا آغاز و ارتقا

موضوع 10:اردو زبان کا آغاز و ارتقا
کسی زبان کے آغاز اور ارتقاء کی داستان کچھ مخصوص تہذیبی اور معاشرتی حالات سے جڑی ہوتی ہے۔ زبان اپنی ترقی یافتہ شکل اختیار کرنے سے پہلے مختلف مراحل سے گزرتی ہے۔ اسے رنگ و روپ دینے اور نکھارنے میں مختلف عوامل کار فرما ہوتے ہیں۔ اردو زبان جو آج کی چند ترقی یافتہ اور کثرت سے بولی جانے والی زبانوں میں سے ایک ہے اسے بھی معرض وجود میں آنے سے قبل مختلف مراحل سے گزرنا پڑا۔ ان مختلف مراحل اور تہذیبی اور معاشرتی عوامل کو سمجھنے کے لئے ہمیں ماضی کی طرف پلٹنا ضروری ہے۔
جیسا کہ تاریخ کے مطالعے سے پتہ چلتا ہے کہ ہندوستان کے قدیم باشندے دراوڑ تھے۔آریا قوم باہر سے آئی اور مقامی باشندوں کو پیچھے دھکیل کر ملک پر قابض ہو گئی۔آریا قوم ملک پر ایک نئی تہذیبی طاقت بن کر ابھری۔ ان کی زبان کو مرکزی حیثیت حاصل ہوئی۔ مقامی باشندوں سے میل جول کی وجہ سے آریاؤں کی زبان متاثر ہونے لگی اور بہت سے الفاظ کا تلفظ کچھ سے کچھ ہو گیا۔ آریاؤں نے اپنی زبان کو محفوظ رکھنے کے خیال سے اسے قواعدی اصولوں سے جکڑ دیا اور اپنی زبان میں صرف ٹکسالی الفاظ باقی رکھے۔مقامی اثرات اس سے پاک و صاف ہو کر ان کی زبان نے اپنا ایک معیار برقرار رکھا اور اسی معیاری زبان کو سنسکرت کا نام دیا گیا۔
اس زبان کو کافی فروغ حاصل ہوا لیکن اس کا رشتہ عوام سے کٹ گیا گیا اور ایک مخصوص دائرے تک سمٹ کر رہ گئی۔ عوام کی زبان مختلف علاقوں میں تھوڑے سے فرق کے ساتھ ایک رسم الخط میں موجود رہیں اس زبان کو پراکرت کا نام دیا گیا۔ پراکرت زبان برابر ترقی کرتی رہی اور مختلف علاقوں میں مختلف روپ اختیار کرتی رہی۔ آگے...

خیبر پختونخوا کے علماء کی تحریر کردہ شروح صحیح بخاری کا تعارفی مطالعہ

Shah Waliullah pioneered the promulgation and publication of Ḥadtih in the Subcontinent. His immediate students and avid readers owned this sacred responsibility and brought forth this beacon of Ḥadtih in Khyber Pakhtunkhwa, posthumously. In the said region, not only a meticulous research has been conducted on assorted genres of Ḥadtih but also a profound work has been executed on its treatise. Especially, “The Ṣaḥiḥ Bukhari” has remained the focus for research and analysis. Besides, in madaris of Khyber Pakhtunkhwa, different sermons and oral disquisitions of the noteworthy religious scholars and Ḥadtih experts (specifically “Ṣaḥiḥ Bukhari”) have been recorded and published in several books and booklets. In this respect, the researcher has uncovered twenty seven published and non-published treatises. In this dissertation, the work of the eminent Ḥadtih scholars is collated, vetted and analyzed, while this introductory analysis is about the Ḥadtih books published particularly during the period ء1901 to ء2015. This research study will be helpful in realizing the arduous efforts and valuable services rendered by the experts in the field of Ḥadtih.

Study of Population Dynamics of Cockroaches Collected from Lahore With Resistance Patterns of Their Isolated Microbial Fauna

Cockroaches are one of the most important pests in urban communities and are risky for human health because they play an important role in transmitting different diseases either mechanically or occasionally biologically. Environmental and sanitary conditions associated with demographic and socio-economic settings of an area could contribute to the prevalence of disease pathogens carried by cockroaches. The present study was aimed to determine taxonomical identification and diversity of cockroaches in hospitals and houses in Lahore, Pakistan and to evaluate the role of cockroaches in transmission of important disease pathogens by using microbial screening of outer surface and digestive tract. Resistance and susceptibility to antimicrobials and disinfectants was also investigated, followed by quantitative and qualitative analysis of total bacterial protein. Four species of cockroaches (P. americana, B. germanica, B. orientalis and B. lateralis) were identified in this study. B. germanica was found to be the most dominant indoors species with highest diversity indices followed by P. americana. Species diversity was highest in July–September, 2013 with highest Simpson index of diversity and Shannon index as well. Population index of B. germanica for hospitals was double than that of residential areas. Houses and hospitals were highly infested with P. americana and B. germanica as compared to offices, shopping malls/ departmental stores and universities. Whereas B. orientalis was commonly found in houses, institutes/universities followed by hospitals, while B. lateralis was common in institutes/ universities, houses and offices with basements and gardens. P. americana was found higher in all trimesters (mean 1179.50 + 351.77) and the analysis of variance revealed a significant difference between the groups (F(3,4)=9.65, P=0.005). Significant correlation was found among changes in temperature and abundance of P. americana in study area (Pearson correlation, r= 0.904, P= 0.04). Similarly temperature showed positive correlation with population of B. germanica (r= 0.958, P= 0.021) and B. orientalis (r= 0.987, P= 0.007). During the study, all cockroaches were found to be infected with at least one bacterium. The most common bacterium isolated from external surface of cockroaches was E. coli (10.31%), followed by S. aureus (10.09%), while P. aeruginosa (19.96%) was isolated from internal gut tract of cockroaches, followed by P. vulgaris (16.08%). Among hospitals the highest in external bacterial infection was observed on P. americana in Punjab Institute of Cardiology (PIC) (75.6%) while ii highest internal bacterial infection was observed in Sheikh Zaid Hospital (SZH) (30.8%). Same trend was observed for bacterial isolation from B. germanica in hospitals. Among houses highest external bacterial infection for P. americana (55.9%) and B. germanica (52%) was observed in samples collected from Shalamar- II. However, highest internal contamination (25.8%) for P. americana was observed in Mughalpura-I locality while highest internal infection (28.8%) for B. germanica was Model town-3 houses. Jaccard’s index of similarity was highest (0.3125) in houses while Bray-Curtis index of dissimilarity was highest for hospital (0.2174). The highest Shannon-Wiener’s diversity index value was found for Punjab Institute of Cardiology (2.610632). All cockroaches had also carried one or more species of medically important mould on their external surface. In this study the most common mold isolated and identified from First Fungal Culture Bank of Pakistan were A. oryzae (84%) and A. flavus (75%) while least common was G. candidum (22%). Cockroaches collected from Shadman-1, Johar town-1 and Shalamar-2 showed relatively high fungal prevalence. P. americana harboured more parasites as compared to B. germanica in both environment. E. coli protozoan was found as the most prevalent followed by E. vermiculari however, A, lumbricoides were least prevalent in hospitals and houses. Simpson Diversity index value of parasitic contaminants isolated from B. germanica collected from houses was 0.92133 and 0.91827 for hospitals. The Shannon-Weiner diversity index calculated value was found highest for P. americana at both sites houses and hospitals as 2.554291 and 2.536765 respectively, which predicted that the rate of parasitic contaminants of both species was not even. Both experimental sites were not significantly different in carriage of parasitic contaminants on cockroaches (F (1,6) =1.795, P= 0.229). Resistance to amoxicillin was found 100% for both gram negative and gram positive isolates followed by cephradine and tetracycline respectively. E. coli was observed as resistant to 3 out of 5 antibiotics (AML, CE, TE) followed by P. aeruginosa that showed resistance to amoxicillin and tetracycline. Germ Kill Vantocil FHC was found more effective bactericide than Germ kill Vantocil in current study. Germ kill Vantocil FHC exhibit highest inhibition zone diameter mean (27+11.575) for 12.5% diluton and 14+13.856 at 50% dilution. Similarly RIZD was 81.81% for 12.5%, dilution respectively. Protein bands of control group were compared with resistant bacterial samples and all protein bands are lying between 236216.2 kDa – 10000 kDa.