Patterns of Deranged Lipid Profiles in Patients of Chronic Hepatitis C Deranged lipid profile in hepatitis C patients

Liver plays an important role in lipid metabolism and any acute or chronic malfunction of the liver due to viral hepatitis or liver cirrhosis may induce lipid derangements Objective: To determine the patterns of deranged lipid profiles in patients of chronic hepatitis C Methods: It is a prospective, observational study, conducted at Medicine Department, Mayo Hospital Lahore for 6 months i.e.1stJanuary to 30th June 2018. After the ethical approval, 160 diagnosed cases of chronic hepatitis C of ages 18-70 years of either gender were selected by non-probability purposive sampling. Informed written consent was taken. Demographic information such as name, age and gender were recorded. Venous blood samples from patients after 10 to 14 hours of fasting were drawn for lipid profiles and sent to pathology laboratory. All results were expressed as mg/dl. Data were analyzed in SPSS version 22 Results: Out of 160 patients in this study, there were 94 males and 66 females. Total cholesterol was lower in 62.5% patients, normal in 33.75% patients and higher in 3.75% patients. Triglycerides levels were low in 66.25%, normal in 33.125%, and high in 0.625% patients. Low density lipoprotein (LDL) levels were low in 82.5% patients, normal in 10% and raised in 7.5% patients. High density lipoprotein (HDL) levels were low in 95%, normal in 4.375% & high in 0.625% patients Conclusions: Low levels of serum lipids including total cholesterol, triglycerides, LDL and HDL are seen in population suffering from chronic HCV infection.

Disease Activity and Functional Status and Their Relation to Depression in Patients With Rheumatoid Arthritis

Introduction: Rheumatoid Arthritis, one of the commonest forms of inflammatory arthritis, has significant societal impact with regards to cost, induction of disability and loss of productivity. This impact is magnified in the presence of comorbid mood disorders, as these constitute independent factors for unexplained flares and relapses. Purpose: The primary purpose of this study was to determine the correlation between disease activity and depression in Rheumatoid Arthritis patients. Methods: Patients with Rheumatoid Arthritis attending rheumatology clinic at Aga Khan University Hospital, Nairobi were recruited into the study. The patients’ disease activity and functional status were assessed using the Clinical Disease Activity Index and the Stanford Health Assessment Questionnaire respectively, whereas the level of depression was evaluated using the Patient Health Questionnaire-9. Pearson’s correlation coefficient was calculated for the disease activity and functional status versus the depression scores, and relationship between the disease activity and depression scores was analyzed using Chi square tables. Results: A total of 60 patients were enrolled into the study, whose mean age was 48.8 ± 13.6 years. There were 52 females (86.7%). The mean duration of RA symptoms was 71.6 ± 86.6 months, with the mean duration of RA treatment being 43.4 ± 64.5 months. Among the study participants, 28.3% had mild depression whereas 35% had moderate/severe depression. There was a strong positive correlation between disease activity and depression (? < 0.001), as well as between physical disability and depression. Conclusion: This study found depressive symptoms in 63.3% of the patients, in spite of the study population being relatively young and having short duration of disease. The significant correlation observed between disease activity and depression illustrates the high likelihood of undiagnosed comorbid depression as a co-existing factor in persistently active disease, poor response to therapy and unexplained flare-ups in the Kenyan Rheumatoid Arthritis population.