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2D Seismic Reflection Data Interpretation Line: 944-Sgr-232N Prospects of Sanghar Area

Thesis Info

Author

Sarfraz Khan

Department

Deptt. of Earth Sciences, QAU.

Program

MSc

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2007

Thesis Completion Status

Completed

Page

66

Subject

Earth Sciences

Language

English

Other

Call No: DISS/M.Sc ES/826

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676718533974

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پہلی اشاعت پرکامیابی

پہلی اشاعت پر کامیابی

                ناطق کی پہلی دس نظمیں 2009ء میں چہار ماہی رسالہ دنیا زاد میںشائع ہوئی۔ایک منفرد لکھاری اور ایک نیا اچھوتا انداز تحریر ہونے کی وجہ سے ادبی دنیا میں پہلی ہی اشاعت پر کامیابی ملی،پہلی بار ہی جب یہ نظمیں رسالہ میں چھپی تومنفرد لکھاری کے طور پر پہچان کا باعث بنی ان کے پہلے مجموعے میں یہ دس نظمیں شامل ہیں۔ان کی اس شاعت کے بعد 2009ء میں "آج"نامی رسالہ میں ان کے پانچ افسانے چھپے۔ناطق کو جب ان کی پہلی اشاعت پر ہی کامیابی کاسامنا رہا تو اردو ادب کے بڑے بڑے لکھاریوں نے ان کو اس کام پہ مبارکباد دی۔

الخطاب الإسلامي ومآلاته على الإنسان معرفيا - سلوكيا - وجدانيا

هدفت الدراسة لدحض الأفكار المتجنية على الخطاب الإسلامي المتنوع، وذلك بالبرهنة على أنه لا توجد أمة انطلقت شموليا، دون الاعتماد على خطاب أصيل لا ينفصل عن اللغة الأم وأصولها، ولتعيين خلل التعثرات، ومساءلة التاريخ والواقع والذات عن مكامن النقص والضعف، ومساهمة في إيجاد الحلول، وتصحيح الذات والتشارك في الفضل، ثم التحرر من الهياكل والأفكار السلبية الموروثة والعمل على تخليقها. ودعت الدراسة الباحثين والعلماء إلى مركزة الخطاب الإسلامي ضمن أولوياتهم وأبحاثهم، نظرا لخصوصياته ومؤهلاته ومكانته الرمزية المستمدة من الكتاب والسنة، ولتحقيق أهداف الدراسة فقد زاوج الباحث بين المنهج الوصفي التحليلي والاستقرائي، مستعينا بعدة مصادر ومراجع في الموضوع للتوثيق والاستشهاد، مع إبداء الرأي في المواطن التي تستدعي ذلك، وتوصلت الدراسة إلى مجموعة من النتائج أهمها: جدوى المراهنة على قدرات اللغة العربية وخطابها المتزن استيعابا للعلوم، وتوحيدا للأمة على كلمة السواء، رغبة في قوة التدين وتخليق الحياة.

Synthesis and Biological Evaluation of Thiazole, Oxadiazole and Indole Derivatives

This dissertation has been divided into four chapters and each chapter has its own numbering of compounds and references. General introduction related to the importance of natural products and natural product based drugs, drug designing and value of lead molecules in drug designing. This research work describes synthesis and bioactivities of different class of heterocycles such as thiazole, oxadiazole and indole analogs in search of important therapeutic agents. During this research study, a variety of thiazole, oxadiazole and indole analogs were synthesized and screened for enzyme inhibition studies (thymidine phosphorylase, α-glucosidase, urease and β-glucuronidase activities). The results obtained from this study are encouraging which are discussed separately in the forthcoming chapters 1, 2 and 3. In the first chapter, thiazole analogs are described. In the thiazole series, sixteen analogs (1-16) were synthesized and evaluated for thymidine phosphorylase inhibitory potential. Out of sixteen analogs, nine analogs such as analogs 1, 2, 3, 5, 6, 8, 10, 13 and 15 showed good phosphorylase inhibitory potentials when compared with the standard 7-Deazaxanthine. The remaining seven analogs showed moderate to good activity. In 2nd chapter, oxadiazole analogs are described. Sixteen analogs (1-16) of oxadiazole were synthesized and evaluated for thymidine phosphorylase activity. Out of sixteen analogs, fourteen analogs such as analogs 1-7 and 9-15 showed excellent thymidine phosphorylase inhibitory potentials which is many folds better than the standard 7-Deazaxanthine. Analog 16 showed good inhibitory potential while analog 8 remain inactive among the series. In chapter third, three series of indole are described. In first series, We have synthesized thirty-two (32) bis-indolylmethane analogs (1-32) with varying degree of β-glucuronidase inhibition potential ranging in between 0.10 ± 0.01 to 48.50 ± 1.10 μM when compared with the standard drug D-saccharic acid 1,4-lactone (IC50 value 48.30 ± 1.20 μM). All of thirty-two analogs 1-32, showed outstanding β-glucuronidase inhibitory potentials. In second series, eighteen derivatives (1-18) of bis-indolylmethane thiosemicarbazide were synthesized and evaluated for their urease inhibitory potential. These derivatives displayed varying degree of inhibition in the range of 0.14 ± 0.01 to 18.50 ± 0.90 μM when compared with the standard inhibitor thiourea having an IC50 value 21.25 ± 0.90 μM. All derivatives showed outstanding urease inhibitory potentials which are many folds better than the standard thiourea. In third series, twenty one analogs of tris-indole hybrid scaffold with oxadiazole ring (1-21) were synthesized and evaluated for α-glucosidase inhibitory potential. All compounds displayed superior α-glucosidase inhibitory activities having IC50 value in the range of 2.00 ± 0.01-292.40 ± 3.16 μM as compared to standard acarbose (IC50 = 895.09 ± 2.04 μM). In chapter four, procedures for different biological assay are described.