راکی ولسن کا’’مینار محبت‘‘
کائنات میں اشرف المخلوقات ہونے کا شرف صرف انسان کو حاصل ہے تمام مخلوقات میں انسان سب سے زیادہ با اختیار بھی ہے۔احساسات و جذبات بھی سب سے زیادہ انسان ہی رکھتا ہے۔اسی لیے وہ ازل سے اپنے خیالات کا اظہار کرتا آیا ہے۔کبھی آرٹ ،تصاویر،لوک داستانیں اور کبھی شعر وادب کی صورت زبان کا اظہار بہترین ذریعہ ہے۔لفظوں کو ایک خاص انداز میں اپنے خیالات کے اظہار لے لیے استعمال کرنا شاعری ہے۔راکی ولسن نے بھی اپنے خیالات کے اظہار کے لیے خوبصورت الفاظ کا استعمال کیا ہے۔اس لیے اسکی شاعری و خود جذبات کے تحت وجود میں آتی ہے۔
راکی نے رشتو ں ناتوں میں بٹے ہوئے انسان کو اس کی خوشیوں،غموں،امنگوں، آرزوؤں،اْمیدوں،نا امیدوں،رویوں اور ولولوں کو اپنا موضوع بنایا ہے۔اسکی بے ساختہ شاعری فطرت انسانی کی عکاس ہے،وہ موضوعاتی شاعری پر بھی طبع آزمائی کرتے دکھائی دیتے ہیں۔انکی شاعری میں متاثر کرنے کی زبردست صلاحیت موجود ہے۔یہ صلاحیت صدق دل اور خلوص نیت کے بغیر حاصل نہیں ہوتی۔یہ خلوص نیت ان کے مجموعہ کلام ’’مینار محبت‘‘ میں محبت بانٹتے ہوئے دکھائی دیتا ہے۔آپ کے اس مجموعہ کلام اجمالی جائزہ کچھ اس طرح سے ہے۔
اگرچہ شاعر نے شاعری کی روایت سے ہٹ کر اس کتا کو شروع کیا ہے۔مگر اس کے باوجود وہ اپنے پروردگار کو بھولے نہیں۔کہتے ہیں کہ ہر شے میں اس ذات باری تعالیٰ کا جلوہ موجود ہے اسی لیے تو کائنات کی ہر شے اس کی خوبصورتی کو دیکھنا چاہتی ہے،آج راکی صاحب جو کچھ بھی ہیں وہ سب اس ذات کی کرم نوازی کی وجہ سے ممکن ہوا ہے:
حسن فطرت کے مظہر ہے تیری شان وجیہہ
تیری دید کی طالب ہر آنکھ شیدائی ہے
ABSTRACT: This article presents an over view of studies conducted by the various scholars about portrayal of Islam and Islamic world during the time period (1971-2001) . It is claimed that mainstream media of west and US have been disseminating false information about Islamic world since the several decades. Due to the distorted images, developed and manipulated by the media, Islam is the name of negativity in the west. It is generally believed that western and United States mainstream media often misrepresents and inaccurately interprets/portrays Islam, Islamic world and its manifestation. After conducting in depth analysis of various studies regarding portrayal of Islamic world prior the incident of 9/11, it was found that elite media in the United States including the newspapers: Like New York Times and Washington post; the magazines: like Time and News Week, electronic media including: like ABC, CBS, NBS & CNN have been highlighting Islamic world in negative and unfavorable manner. It is said this anti Islamic campaign has reached to enormous proportion with the demise of communism. The that negative image of Islamic country is primarily a conspiracy of American foreign office to invent a new bogy and enemy to fill vacuum created by the collapse of soviet Union and world wide desperation of communism, particularly demise of communism in former USSR
Epilepsy is a chronic neurologic disorder result from electrical disturbances that lead to abnormal discharge of neurons within the CNS. This discharge produced unprovoked and recurrent seizures which alter the normal brain functions. These functional alterations often give rise to behavioral abnormalities, with devastating effect on the patients and their families. To date, major advancement has been done in the treatment of epilepsy, but still, epilepsy is a great challenge in the medicine field which pays attention towards the invention of new and more potential AEDs. Regardless of latest advancement in the epilepsy, an about one third population is unresponsive. So, the proposed underlying mechanism of transfer of normal brain to epileptic is still unanswered and this highlight to identify new targets of drug treatement. For it , we established the seizure threshold, and used exogenous antiepileptogenic mediator i.e., isoxylitones [E/Z] to evaluate if this can control the over expressed JAK-STAT pathway in the model of epileptogenesis and finally discuss the attempts to halt the process of epileptogenesis by regulating the JAK-STAT pathway. From ancient time to present, there is a strong history of usage of plants and their extracts in the treatment of different neurological disorders. Delphinium denudatum is a medicinal plant of Himalayas and Kashmir, locally called Jadwar. This plant is claimed by many local practitioners to be used in seizure treatment. The novel antiepileptic compound ISO[E/Z] was initially isolated from the same plant and later it was synthesized. Previous studies in our lab already reported that ISO[E/Z] have potent antiepileptic effect. It is able to reduce the seizures in kindling model of epileptogenesis. This inhibition of seizure was further confirmed by modulation of BDNF, cfos and through blockage of sodium channel. In current study, we explored the effect of ISO[E/Z] at the molecular and cellular level by targeting JAK-STAT pathway, that is involved in the epileptogenesis process. The ISO[E/Z] was re-synthesized by our collaborator’s team, X therefore in order to validate and standardize the fresh supply of ISO[E/Z], we re-tested the compound both in acute and chronic seizure model. This step was carried out in order to keep compliance with previous findings. For present study, we choose JAK-1, JAK-3, STAT-2 and STAT-5a isoforms of JAK-STAT pathway due to their importance and involvement in the process of epileptogenesis. We found over expression of mRNA and protein of the above mentioned biomarkers in both cortex and hippocampus of untreated PTZ-kindled group. However, the treatment of ISO[E/Z] was able to reduced the JAK-1, JAK-3, STAT-2 and STAT5a expression. These findings suggest that ISO[E/Z] can halt the epileptogenesis progression by interrupting the underlying functional changes at molecular level. Moreover, our findings also validate our previous studies on isoxylitones with a promising compliance. In the light of all these observations, it can be said that isoxylitones in future would be a potential AED in the treatment of refractory epilepsy. At this stage, promising data support the further development of ISO[E/Z] as an inhibitor of JAK-STAT pathway and this strategy is expected to be valuable to modify or prevent the epilepsy. We think, for an adequate control, it is necessary to used a combination of drugs that hit the multiple targets which are the main players underlying epileptogenesis.