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Computer Aided Identification and Synthesis of Some Aza-Heterocycles As A-Glucosidase Inhibitors

Thesis Info

Author

Sumaira Kanwal

Department

Department of Chemistry, QAU

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Page

xv,101

Subject

Chemistry

Language

English

Other

Call No: Diss / M. Phil / CHE / 1257

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676718926810

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کیوں رشک سے نہ دیکھیں شاعر زباں گری کے

کیوں رشک سے نہ دیکھیں شاعر زباں گری کے
اترے ہیں مجھ پہ مصرعے کچھ بھرتری ہری کے

بس اک نگہ سے اس کی، ہیں محوِ رقص بادل
اُس آنکھ میں تھے ساون جادوئے سامری کے

کچھ یوں ہَوا ہوئی ہے عجز و نیاز مندی
جلوے سما گئے ہیں مجھ میں بھی خود سری کے

یہ چھوڑ بیٹھا کعبہ ، وہ دَیر سے گیا ہے
اُس کی گلی کے منظر آئنے کافری کے

چھیڑو غزل کچھ ایسی جو دل کے تار چھیڑے
مطلوب ہیں فضاؔ کو قصے جو دلبری کے

احادیث ِنزو لِ مسیح ابن مریم علیہما السلام میں قادیانیوں کی تاویلات کا تنقیدی جائزہ A Critical Review of Interpretations of Qādiyānies in Aḥadīth of Nuzūl Al-Masīḥ Ibn e Maryam (علیہما السلام)

The negation of the crucifixion and murder of Maseeh علیہ السلام and the ascension to heaven are mentioned in the Holy Qur'an and the revelation to the earth is mentioned in the authentic Ahadith. The Holy Qur'an and Hadith do not contradict each other on the ascension and revelation of Maseeh علیہ السلام. Mirza Ghulam Ahmed Qadiyani interpret those thirty verses of the Holy Qur'an are about the death of Maseeh علیہ السلام which have nothing to do with his death. The Hadiths of the revelation of Maseehعلیہ السلام benefit from the Holy Qur'an, not derived from any Ijtihad or Israelism. The word death is not mentioned for Essa علیہ السلام in the Holy Qur'an. It is not possible for the Hadith to describe the return of Essa علیہ السلام to earth before the Day of Judgment and let his death be mentioned in the Holy Qur'an. Otherwise, instead of stating the meaning of Holy Qur'an, the Hadith will contradict the Qur'an. The Qur'an mentions the ascension of Essa علیہ السلام to heaven and the Hadith describes the revelation to the earth. There is not a single Hadith that indicates that Essa علیہ السلام refers to Mirza Ghulam Ahmed of Qadian and his descent means that is born from the mothes’s womb, or it is a descent as buroz (بروزی).

Genetics of Production Traits and Stripe Rust Resistance in Bread Wheat under Rainfed and Irrigated Conditions

Understanding inheritance and biotic stress resistance is of crucial importance for the genetic improvement of any field crop. Wheat (Triticum aestivum L.) is one of the most important cereal crop. In the present studies, 8 × 8 diallel crosses were conducted in wheat during 2014-15. All the 56 F1 hybrids along with parental genotypes were evaluated during 2015-16 under irrigated and rainfed conditions to determine the genetic control of various traits and to find out resistance to stripe rust by using molecular markers. The experiment was conducted in completely randomized block design with 3 replications at the Department of Plant Breeding and Genetics, The University of Agriculture Peshawar-Pakistan. Molecular study was carried out in the Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar and at Plant Breeding Institute, The University of Sydney, Australia. Pooled analysis showed highly significant genotypes × environment interaction for all the studied characters except days to maturity, final rust severity (FRS) and relative area under disease progress curve (rAUDPC). Under both conditions among the genotypes significant differences were observed for the studied parameters. Among the parents, PS-13, JB and PS-05 performed well under both conditions. Under irrigated condition, cross combinations, Lal-13 × JB, KW ×PS-05 and JB × AH while under rainfed condition, cross combinations, PS-05 × PJ-11, Tat-96 × AH and JB × AH, showed best performance for yield and yield related characters. Under irrigated conditions maximum best parent heterosis was observed for cross combinations, KW × Lal-13, Lal-13 × PS-05, Tat-96 × PJ-11 and Lal-13 × JB, whereas, under rainfed conditions, JB × AH, PJ-11× Tat-96 and PS-13 × AH were best heterotic combinations for yield and yield contributing traits. Natural disease infestation was scored for disease infection under both conditions. Under irrigated condition cross combinations, Lal-13 × JB, KW × PS-05, JB × AH, KW × PS-13, Tat-96 × KW and PS-05 × AH and under rainfed condition cross combinations, PS-05 × PJ-11, Tat-96 × AH, JB × AH, Lal-13 × AH and Tat-96 × PS-05 showed best performance for most of the traits. Under both ii environments the genotypes were classified into different groups of high, moderate and low level of partial resistance on the basis of FRS, rAUDPC and average coefficient of infection (ACI) values. Through molecular study, using simple sequence repeats (SSRs) markers, the presence of yellow rust resistance genes, Yr5, Yr17 and Yr18, were confirmed in 76.5%, 78.1% and 37.5%, respectively, of the material studied. Under rainfed condition genotypes PS-05 × AH, PS-05 and PS-13 × PS-05 and under irrigated condition, Lal-13 × JB, PS-05 × Lal-13, PS-05 × Tat-96 and JB × PS-05 showed partial resistance in field. The rust resistant genes conferring partial resistance were present either individually or in combinations of two or three in the genotypes. In diallel analysis, under both irrigated and rainfed conditions highly significant dominant ‘b’ and additive ‘a’ genetic effects were observed for the studied characters except spikelets spike-1 having non-significant gene effects under both conditions and grains spike-1 having non-significant dominant gene effect under rainfed condition. Additive-dominance model was from complete to partially adequate for various characters under both environments. Similarly, for the studied characters both dominant (H) and additive (D) genetic components were significant under both environments. High broad and narrow sense heritability was estimated for all of the studied parameters except days to maturity, days to heading, 1000-grain weight and biological yield plant-1 which possessed low narrow sense heritability. Mean squares of SCA and GCA analysis were highly significant for the studied parameters except spikelets spike-1 and spike length which remained non-significant under both conditions, whereas, fertile tillers plant-1 remained non-significant under irrigated conditions only. SCA mean squares were smaller than GCA mean squares for yield and yield contributing traits indicating preponderance of additive genetic effects. Under irrigated condition cross combinations, PS-05 × JB, Tat-96 × PJ-11 and AH × PS-05 were best specific combiners while under rainfed condition AH × JB, AH × Tat-96 and PJ-11 × PS-05 were the best specific combiners for yield and yield associated traits. Based on overall results, crosses combinations, Lal-13 × JB, PS-13 × AH and PS-05 × AH were better yielders and had lower yellow rust severity and are recommended to be exploited in future breeding programs. These results suggested the significance of additive and dominant genetic variability and through integrated use of diallel crossing technique or pedigree method with recurrent selection, efficient improvement is possible.