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Effect of a Neuroexcitatory Amino Acid on the Hypothalamic-Pituitary-Gonadal Axis

Thesis Info

Author

Tarranum Naz

Department

Deptt. of Biological Sciences, QAU.

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

1988

Thesis Completion Status

Completed

Page

37

Subject

Biological Sciences

Language

English

Other

Call No: DISS/M.Phil BIO/169

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676719113531

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کاکا محمد اسمٰعیل مدراسی

کاکا محمد اسمٰعیل مرحوم مدراسی
( مولوی ثناء اﷲ)
کاکا اسمٰعیل صاحب مرحوم قوم ملت کی ان شخصیتوں میں تھے، جنھوں نے لاکھوں روپیہ کمایا اور لاکھوں قوم و ملت کی راہ میں صرف کیا، ہندوستان کے بہت سے مذہبی و قومی ادارے ان کی فیاضی سے سیراب ہوئے تھے، ایسے محسن قوم کے حالات سے دوسرے ارباب ثروت سبق حاصل کرسکتے ہیں۔ (شاہ معین الدین ندوی)
علاقہ مدراس ضلع نارتھ آرکاٹ کا تاریخی مقام گڑھ آمبور کاکا محمد اسمٰعیل صاحب کا وطن تھا، آپ کے والد کاکا حاجی محمد عمر صاحب ایک دیندار بزرگ، دولتمند تاجر علماء کے عقیدت مند، فیاض اور غریب پرور تھے، دینی اور اصلاحی کاموں میں پیش پیش رہتے تھے، مدراس کی روشن کمپنی جو علم نوازی میں مشہور تھی اور اب بند ہوگئی آپ اس کے ایک رکن تھے، گڑھ آمبور سے متصل اپنے نام کی مناسبت سے عمرآباد نامی ایک گاؤں آباد کیا اور وہیں ایک اعلیٰ دینی درسگاہ و مدرسہ دارالسلام کے نام سے ۱۹۲۴؁ء میں قائم کی چند ہی سال بعد دسمبر ۱۹۲۷؁ء میں آپ کا انتقال ہوگیا، آپ کے بعد آپ کے فرزند اکبر کاکا محمد اسمٰعیل صاحب نے جملہ کاروبار کو نہایت خوبی سے سنبھالا، والد مرحوم کی جملہ خوبیوں کے علاوہ آپ میں اور بھی بہت سے کمالات تھے، علمی اور دینی خدمت کے جذبہ سے سرشار تھے، دولت کا بیشتر حصہ ملی و قومی کاموں میں خرچ کرتے تھے، صاحب دل مخلص، موحد اور متبع سنت تھے، متعدد علمی ادارے بذات خود چلارہے تھے، حسب ذیل ادارے آپ کی یادگار ہیں:
۱۔ جامعہ داراسلام عمر آباد: یہ ایک اعلیٰ دینی درس گاہ ہے جس طلباء کی تعداد سوسے متجاوز ہے، اس میں رہائش، خوراک اور درسی کتابوں کا انتظام بغیر کسی فیس کے مدرسہ کی طرف سے ہوتا ہے، اساتذہ کی تعداد گیارہ بارہ...

The Aligarh Miracle

Social movements are considered to be a modern phenomenon but they have existed in the past as well. Aligarh movement initiated by Sir Sayyid Ahmed khan is a typical social movement from 19th century, aimed at modernization and uplift of the Muslim community of India. It emerged in a period when the Indian Muslims were facing a sharp decline in their socio-economic and political status. This decline had created a psychology of retreat among them wherein they suspected any attempt to reform their lot. For instance, the introduction of modern education by the British rulers was adopted by the Hindu majority for obvious economic benefits. Conversely, the Muslims remained wary of modern education, particularly the English language as a conspiracy to destroy their age-old culture and religion. In this backdrop Sir Sayyid Ahmed Khan’s tireless drive to inculcate modern education proved to be a miracle that transformed the Muslim middle classes for the next century. Although Aligarh movement has attracted tremendous scholarship, there has been virtually little attempt to theorize it as a social movement. In this context the present paper aims to study Aligarh Movement on the parameters of contemporary theories highlighting the causal dimensions of social movements. It will particularly explore the relevance of the elements of deprivation, resource mobilization, political processes, structural strain and those highlighted by the new social movement theory as causal factors in the emergence and evolution of Aligarh Movement.

Evaluation of Hypertonic Saline Solution in the Treatment of Haemorrhagic Septicaemia, Calf Scour and Other Clinical Conditions of Livestock Characterized by Hypovolaemia / Endotoxaemia

This study was conducted for the evaluation of hypertonic saline solution in haemorrhagic septicaemia (HS) in buffaloes, calf scour in buffalo calves and other clinical conditions of livestock characterized by hypovolaemia and/or endotoxaemia including spontaneous cases of calf scour, dehydrated diarrhoeic goats and buffaloes. For this purpose, 50 buffaloes were selected from the field suffering from HS. The disease was diagnosed on the basis of clinical signs. Then theses animals were randomly divided into two equal groups (A and B). Buffaloes of group A were treated with the conventional treatment already in vogue i.e. ceftiofur HCl and flunixin meglumine @ 6 mg/kg and 2 mg/kg BW, IM and IV, respectively. Group B was treated with intravenous infusion of hypertonic saline solution (HSS) @ 4 mL/kg BW followed by isotonic saline solution @ 10 mL/kg BW along with ceftiofur HCl and flunixin meglumine. For evaluation of HSS in calf scour, neonatal diarrhoea in buffalo calves (n=24) was induced through oral administration of 2 mL broth culture of having eneteropathogenic E. coli count of 10 10 CFU. To evaluate the efficacy of HSS in clinical conditions of livestock, spontaneous cases of calf scour (n=24), dehydrated diarrhoeic goats (n=24) and buffaloes (n=24) were studied. In all these conditions, the animals were randomly divided into two equal groups viz. A and B (n=12 each). Group A was treated with isotonic (90 mL/kg BW) and group B with hypertonic (4 mL/kg BW) saline solutions along with ceftiofur HCl and flunixin meglumine (6 and 2 mg/kg BW, respectively). The efficacy of treatment was evaluated on the basis of clinical parameters, haematological analysis, haemodynamic parameters, blood gas analysis, serum electrolytes and serum biochemical profiles. These all evaluation parameters were recorded at baseline (during disease), t=1, t=3, t=6, t=12, t=24 and t=36 hours after treatment. However, for induced calf scour, the additional recording time point was before induction of diarrhoea which acted as baseline; other recording time points being the same as for other conditions studied. Hypertonic saline infusion to the buffaloes of group B suffering from HS showed significantly higher survival rate of 80% and differed significantly (P < 0.05) from group A in which survival rate was 52%. Group B significantly (P < 0.05) improved heart rate, mean arterial pressure, central venous pressure, haematocrit and haemoglobin concentration, partial pressure of arterial oxygen, blood pH and total serum protein. Hypertonic infusion increased serum sodium and xiiichloride ions concentration but the changes were not of sufficient magnitude to be of risk to the buffaloes. Hypertonic saline solution (group B) resuscitated buffalo calves from neonatal diarrhoea (either induced or spontaneous) more rapidly and effectively than isotonic saline solution (group A) and showed significant (P < 0.05) improvement in all the parameters studied. The resuscitation of diarrhoeic dehydrated goats (n=24) and buffaloes (n=24) through administering hypertonic saline solution was evaluated. Both treatment protocols helped in recovering the normal values of all the parameters studied within experimental period. But hypertonic saline solution showed significant differences (P < 0.05) over group A in heart rate, mean arterial pressure, central venous pressure, partial pressure of arterial oxygen, blood pH and bicarbonates in diarrhoeic goats. In diarrhoeic buffaloes, HSS infusion only showed significant difference (P < 0.05) over group A in partial pressure of venous oxygen, while other parameters were recovered to normal without any statistical difference. On the basis of findings of this study, it was concluded that hypertonic saline solution can be safely administered to the buffaloes suffering from haemorrhagic septicaemia and buffalo calves with neonatal diarrhoea. It offset deleterious haemodynamic effects of endotoxins, thus ameliorates the septic shock more effectively than does antibiotic therapy alone in HS. In addition to rapid and effective, intravenous administration of a small volume of HSS provides a practical and economical method to resuscitate dehydrated calves with neonatal diarrhoea, diarrhoeic goats and buffaloes, thus make it suitable for field use.