Search or add a thesis

Advanced Search (Beta)
Home > Accounts Information System

Accounts Information System

Thesis Info

Author

Umar Zubair

Department

Deptt. of Computer Sciences, QAU.

Program

MSc

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

1999

Thesis Completion Status

Completed

Page

47

Subject

Computer Sciences

Language

English

Other

Call No: DISS/M.Sc COM/945

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676719188762

Similar


Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

زندگی کی بو قلمونیاں اور رنگا رنگ حقائق

زندگی کی بوقلمونیاں اور رنگارنگ حقائق
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
صدرِذی وقار!آج مجھے جس موضوع پر اظہار خیال کرنا ہے:’’وہ زندگی کی بوقلمونیاں اور رنگارنگ حقائق کے بارے میں ہے‘‘
جناب!
زندگی ایک ابدی خوشی کا نام ہے۔ زندگی ایک غیر مرئی چاہت کا نام ہے زندگی جگنو کے نور کا نام ہے، زندگی دل کے سرور کا نام ہے۔
جنابِ صدر!
زندگی ایک ایسا پھول ہے جس کی مہک سے گلشنِ حیات کی فضا معطر ہوجاتی ہے۔ زندگی ایک ایسے جذ بے کا نام ہے جو نا امیدی کی دلدل میںکبھی نہیں گرنے دیتا، زندگی ایک ایسی چمک کا نام ہے جس سے مُردنی اور موت کے سائے بھاگ جاتے ہیں۔
صدرِ ذی وقار!
زندگی نے ہی تو مجھے معاشرے میں چلنے کا سلیقہ سکھایا، زندگی نے ہی تو مجھے قبیلے کا ایک اہم رکن بنایا، زندگی نے ہی تو حرارت ِایمانی بخشی، زندگی نے ہی تو مجھے عبادت کا ڈھنگ سکھایا، زندگی ہی نے مجھے خود شناسی کے علاوہ خداشناسی بخشی۔
معزز سامعین!
میرے مخالف نے تو حد کر دی ہے۔ لیکن کیا ہوا مخالفوں نے تو مخالفت تو کرنی ہی ہوتی ہے، زندگی کو ایک مصیبت کے طور پہ پیش کیا ہے، زندگی سے مخاصمانہ رویہ محمودنہیں ہے، زندگی خود اس کی آمد کا سبب ہے، اُس کے والدین کی زندگی اُس کی حیات نو کا سبب ہے۔
جنابِ صدر!
زندگی ہے تو بطخ کا بچہ بھی تالاب میں تیراکی کرتا ہوا اچھا لگتا ہے، زندگی ہے تو فلک کی بلندیوں پرمحو پرواز طائر خوش الحان کی اڑان میں انفرادیت نظر آتی ہے۔ زندگی ہے تو شاخِ مغیلاں پر چہکتی ہوئی کنجشک مادہ اپنے بچوں کو چوگ دیتی ہوئی اچھی لگتی ہے۔
معزز سامعین!
میں یہ...

خلافت اور جمہوریت نتائج و عواقب عصر حاضر کے تناظر میں

Islām is a complete code of life. Man is the vicegerent and representative of Allāh. The role of vicegerent and caliphate can only be fulfilled in a complete manner, when the system of the Islamic Caliphate is established. It is the duty of Muslims to endeavor for establishing such a system in the world. The caliphate is the political title of Islām. It is, actually, the sovereignty of Almighty God on the earth. God creates its sovereignty by selecting the pious people from the humankind. With the help of Caliphate, unity, strength and equality can be established in the Muslim world. Democracy is the system of government, which is based on the wishes of the majority of the people of a state. However, the real democracy is the one in which wishes of people are directly or indirectly catered. An ideal democracy is the one in which all affairs of the country are run with the consultation of all the people. If the affairs of any state are run by the majority of the people, then that state will move towards its destruction. Allāh says, “O Muhammad.. ! If you obey most of the dwellers of the earth they will lead you astray from Allah’s way. ” The affairs of the Islamic state must not run by the wishes of the majority nor the minority of the people, but, on the values of truth and justice. The author of this paper presents a critical and comparative study of the Islamic Caliphate and democracy, and concludes that it is the Caliphate and not democracy, which is the true Islamic system of government.

Plasma Proteomics Analysis of Hydroxyurea Treated Patients Suffering from Thalassemia

β thalassemia is the most prevalent autosomal recessive disorder characterized by absence or reduced production of hemoglobin (Hb) levels, primarily caused by mutations on β globin locus. β thalassemia is heterogeneous at the molecular level, presenting variable phenotypes accompanied with severe medical complications. Current standard of care for clinical management of β thalassemia includes regular, long-life safe blood transfusion along with appropriate iron chelation therapy. At present, the only permanent cure is bone marrow transplantation. An emerging and exciting therapeutic approach to handle β thalassaemia is production of fetal hemoglobin (HbF) which is major Hb of fetal life. In recent years, Hydroxyurea (HU) has proven to be a promising HbF augmenting agent but response to HU therapy varies from transfusion elimination to insignificant clinical response. Various approaches are being made to understand the mechanism HbF augmentation with differential responses. Advancement in proteomics offers an efficient tool to study differential proteome in response to treatment leading towards precision and personalized medicine. This study is designed to improve mechanistic understanding of proteomic changes that HU therapy exerted on β thalassemia patients, in consort with deciphering differential protein expression in HU responder and non-responder. Firstly, samples were subjected to twodimensional gel electrophoresis to assess differentially expressed proteins. Later, differential proteins were identified by label free quantitative proteomics approach. Two hundred and eighty seven proteins were identified with two or more unique peptides in samples studied. Among these, twenty eight proteins were found to be significantly different in pre versus post HU treated β thalassemia patients at probability of < 0.05. Eighteen proteins were down-regulated while ten were found to be up-regulated after HU treatment. Clinically important proteins include Hemopexin (HPX), Haptoglobin (HP), Haptoglobin-related protein (HPR), Hemoglobin subunit beta (HBB), Hemoglobin subunit delta (HBD), Hemoglobin subunit alpha (HBA1), Protein S100-A8 (S100A8), Apolipoprotein L1 (APOL1), Apolipoprotein C-I (APOC1), Transferrin receptor protein (TFRC), Complement C4-A (C4A), Apolipoprotein A (LPA), Ceruloplasmin (CP) and Ficolin-3 (FCN3). HU therapy in β thalassemia patients started reverting protein profile towards healthy pattern, in addition with decrease in transfusion requirements. A follow up study on plasma of HU treated β thalassemia patients was performed to compare proteomic profile of HU responder and non-responder. Twenty six proteins were found to be differentially expressed in HU responder versus non-responder at p < 0.05. Among these, fifteen proteins showed a significantly increased level while eleven proteins revealed a decreased in expression. Clinically relevant altered proteins in HU responder are Peroxiredoxin-2 (PRDX2), Carbonic anhydrase 1(CA1), Hemoglobin subunit gamma-1 (HBG1),Hemoglobin subunit beta (HBB), Hemoglobin subunit delta (HBD), Hemoglobin subunit alpha (HBA1), Properdin (CFP), Cholinesterase (BCHE), Phospholipid transfer protein (PLTP) and Plasma protease C1 inhibitor (SERPING1). We suggest that further research would be required for validation of identified proteins in large cohort to endorse as potential predictive biomarker for HU therapy. Considering the association of oxidative stress with β thalassemia, we also studied markers of oxidative stress in response to HU therapy in β thalassemia covering Paraoxonase1 (PON1), Reactive oxygen species (ROS), and Malondialdehyde (MDA). Although PON1 serve as an antioxidant to reduce the adverse effects of the oxidative stress in β thalassemia, our results indicate that mode of action of HU may not directly be through oxidative imbalance