عبداللطیف اعظمی کی وفات
(سبط محمد نقوی)
آج ۱۸؍ مئی کو لکھنؤ کے ایک اردو روزنامے میں رضا لائبریری رامپور میں منعقدہ ایک تعزیتی جلسے کی کاروائی نظر سے گزری، اس میں تین ادیبوں کی وفات پر اظہار غم دالم کیا گیا ہے۔ ان میں سے ایک نام محب محترم عبداللطیف اعظمی صاحب مرحوم کا بھی ہے۔ ان کے ایسے مستند دانشور کے فقدان کا جو صدمہ ہوا وہ اپنی جگہ پر ہے۔ اس کا ملال مستزاد ہے کہ وہ بہت چپ چپاتے رخصت کردیئے گئے۔ ریڈیو پر بھی یہ خبر اذیت اثر سننے کو ملی۔ لکھنؤ کے ان تین اردو اخباروں میں نظر سے گزری جو ہمارے یہاں آتے ہیں۔
مرحوم جامعہ ملیہ اسلامیہ کے انتظامی عملے میں تھے لیکن تعلیمی دور سے لے کر سبکدوشی کے بعد تک مرحوم کا قلم گل افشاں رہا۔ مولانا شبلی نعمانی مرحوم کے دفاع میں ان کا جہاد اور ماہنامہ جامعہ کے احیاء میں ان کی سعی مشکور۔ ان کے عدیم النظیر تاریخی کارنامے ہیں۔
مرحوم سے ملاقات کے موقع تو بس تین چار بار آئے مگر خط و کتابت کافی رہی۔ آخر میں میرے کسی فقرے سے بددل ہوکر مراسلت کا سلسلہ قطع کردیا تھا، پھر بھی کسی بات کے سلسلے میں ہیچ مداں کے معلومات جاننا چاہے تھے تو یاد فرمایا تھا۔
مجھے نہایت خوش اخلاق، مہمان نواز اور کریم النفس انسان لگے۔ ان سے آخری ملاقات جب ہوئی تو برادرم ضیاء الحسن فاروقی صاحب بھی وہیں تشریف فرما تھے۔ یہ ملاقات ان دونوں حضرات سے آخری تھی۔ افسوس ہے کہ وہ نسل بھی اب اٹھتی جاری ہے، جس نے بزرگان پیشیں کے دور کا ادراک کیا تھا۔ میں ان دونوں کے لئے دعائے مغفرت کرتا ہوں۔ فقط والسلام: سبط محمد نقوی۔ ( جون ۲۰۰۲ء)
عبداللطیف اعظمی
افسوس ہے کہ ۱۰؍ مئی ۲۰۰۲ء کو...
Islam, as a religion, has a clear distinguished. It gives evident rules, religious obligations, terms and conditions to his followers. Every Muslim should follow these commands. The logic behind the traditions of holy prophet (pbuh) which are in prohibition of resemblance with polytheist and unbelievers is, these are compulsory for a religious person to remain in touch his own culture and civilization. Through the traditions of the holy prophet, we concluded that he (pbuh) strictly disliked any Muslim to adopt and copy of non-Muslim’s deeds which leaving Islamic culture civilization, because all the non-Muslims have their own religious obligations. However, Islam condemn all religious obligations, festivals and conditions that are against Islam. If, a Muslim is doing such deeds against the teaching of Islam, what would be the result of this behavior and attitude according to Islam? In this article, same rules and conditions are discussed to discriminate the differences and its impact between the cultures of Islam and other religions. What would be the result of this behavior and attitude according to Islam? And author presented many principles is this regard so a Muslim may be able to distinguish his religious and as well as his cultural values in Islamic society.
Synthesis, Characterization and In–vitro Evaluation of Anticancer Potential of Chitosan–coated Polyoxometalates Nanoparticles Polyoxometalates (POMs) are discrete anions and have become significant in biomedical research due to their structural diversity which renders them highly active against bacterial, viral, cancer and HIV infection. In this study six different POMs were resynthesized and encapsulated within chitosan (CTS) through inotropic gelation technique. The synthesized nanoparticles were characterized in terms of their surface morphology, particle size and zeta potential. All nanoparticles were observed non–spherical with hollow surface having particle diameter below 200 nm. For each formulation the observed zeta potential value was in acceptable limits (> 25 mV). The lowest particle diameter (91 ± 4 nm) was recorded for CTS–TiW11Co with zeta potential 52.0 ± 5.21 mV. The entrapment efficiency, dissolution studies and release kinetics were estimated for all nano formulations. The CTS–P5W30 nanoparticles showed the maximum entrapment efficiency (92 ± 9 %) while the release pattern of POMs from nanoparticles was observed as diffusion and polymer surface erosion. Enzyme inhibition study on tissue non–specific alkaline phosphatase was determined where free POMs and their nanoparticles were analyzed and compared with the standard inhibitor. The inhibition constant (Ki) value for CTS–TiW11Co (10.2 ± 9 ng/mL) was ten–fold lower than the Ki of levamisole (137.5 ± 29 ng/mL). The anticancer potential of free POMs and CTS conjugated nanoparticles were studied on two different cancer cell lines including human cervical cancer cells (HeLa cells) and human breast cancer cells (MCF–7 cells). Furthermore, the toxicity of these compounds was studied on normal cells (vero cells). The compounds CTS–TiW11Co and CTS–P5W30 were very effective on HeLa cells with IC50 of 8.94 ± 2.33 and 7.26 ± 2.55 μg/mL respectively. While these compounds showed the minimum toxicity on vero cells. The CTS–TiW11Co and CTS–P5W30 compounds also showed the lowest IC50 values when tested on MCF–7 cells with 4.55 ± 1.98 and 6.36 ± 1.22 (μg/mL) correspondingly. Based on maximum potential of cytotoxicity on x cancer cells and low toxicity toward normal cells, CTS–TiW11Co and CTS–P5W30 were selected for further experiments. The CTS–TiW11Co and CTS–P5W30 were morphologically analyzed for any signs of apoptosis with DAPI staining. The treated cells (HeLa and MCF–7) were characterized by chromatin condensation, cell shrinkage and formation of apoptotic bodies. A microscopic analysis of the production of reactive oxygen species (ROS) was carried out with the help of fluorescent dye DCFH–DA. The dye was incubated with HeLa and MCF–7 cells after treatment with CTS–TiW11Co and CTS–P5W30 nanoparticles. The treated cells were characterized by glowing cells showing signs of lipid peroxidation and chromatin condensation. Furthermore, a DNA fragmentation analysis was carried out on HeLa and MCF–7 cells separately. The existence of DNA fragments had confirmed apoptosis in HeLa and MCF–7 cells treated with CTS–TiW11Co and CTS–P5W30 nanoparticles.