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Responsiveness of Tertiary Care Hospital

Thesis Info

Author

Zubaida Lodhi

Department

Abhinav Publications

Program

MSc

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Page

70

Subject

Health Sciences

Language

English

Other

Call No: DISS/M.Sc HSA/07

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676719443602

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المبحث الثاني: الشاعرات الباکستانيات في اللغات الباكستانية المختلفة

المبحث الثاني: الشاعرات الباکستانيات في اللغات الباكستانية المختلفة
ھناك بعض الشاعرات في اللغات المختلفۃ غیر الأردو في الباكستان اللاتي قدّمنَ الکثیر من الشعر والأدب ولھن الفضل الکبیر في الأدب الباکستاني.
الأدب النسائي في اللغة البراهوية
تعتبر مائی تاج بانو الشاعرۃ والأدیبۃ المعروفۃ في البراھویۃ وھي مثل والدھا محمد عمر دین پوری الذي عمل الکثیر لإصلاح العوامل النسائیۃ ولمصلحة المجتمع۔
الأدب النسائي في اللغة السرائيكية
ومنھن دائی پھاپھل حفظاني والثانیۃ جیون خاتون وھي ابنۃ حکیم کبیر خان البلوج ولدت في 1800 ولھا الفضل الکبیر في تربیۃ ملك الشعراء ’’خواجہ غلام فرید‘‘ وقد اھتمت بہ وأرضعتہ واھتمت بتربیتہ، وتوفیت في 1876ء وقد نظمت الکثیر من الأشعار .
الأدب النسائي في اللغة البلوشية
الشاعرۃ بانك سیمك، والشاعرۃ حاني وراني لھما الدور الکبیر فی نظم الشعر في اللغۃ البلوشیۃ، وقیل عن الشاعرۃ بانك سیمك إنھا نظمت في ذکری زوجھا وفي فراقہ الکثیر من الأبیات الجمیلۃ۔
الأدب النسائي في اللغة البنجابية
ویفوق الأدب البنجابي جمیع آداب اللغات الأخریٰ ومن أشھر الشاعرات امرتا پریتم التي توفیت منذ سنوات قلیلۃ وھي من أقدم شاعرات البنجاب والتي بدأت بالنظم قبل توحید باکستان، ومن أشھر کتبھا (جیوندا جیون) الحیاۃ الحیۃ، وتناولت الحالات الإجتماعیۃ والتکالیف الإنسانیۃ ومظالم الناس۔
الأدب النسائي في اللغة السندية
ومن أھم شاعرات السند مائی مرکھاں شیخ، وھي أول شاعرۃ سندھیۃ، والثانیۃ مائی ساراں التي نظمت في ذکری زوجھا وفراقہِ، وجادل جتني کانت امرأۃ جمیلۃ ولھا الکثیر من العشاق، ومن أھم الشاعرات أیضاً مائی نعمت شاہ عبداللطیف بھتائی، ومائی غلام فاطمہ لعل وصاحبۃ الکتاب (الأول) سندري دھلرا مانی ۔
الأدب النسائي في اللغة الکشميرية
من القرن الرابع عشر إلی القرن الثامن عشر أضافت الشاعرات الکشمیرات إلی الشعر الکشمیري الکثیر من التطورات والابتكارات الأدبیۃ ومن أھمھن: ﷲ عارفہ، أرني مال، وروبہ بھوانی وغیرھن من الشاعرات المشھورات، وکان ل(ﷲ عارفہ) مکانۃ عظیمۃ في الساحۃ الأدبیۃ وعملت الکثیر لتزکیۃ النفس وکان الناس یعتبرونھا متقربۃ عظیمۃ إلی...

From the Chief Editor's Desk

Medical journals are a credible source of disseminating research and innovations, and Launching a medical journal is a challenging task. Many medical science journals are establishing a platform to publish quality research but still the task is tough and requires perseverance and hard work. Shalamar Medical and Dental College (SMDC) Lahore, strives to promote a culture of research. As part of this initiative, SMDC had launched ‘Medical Journal of Sakina Begum Institute’, but publication of the second volume was delayed due to the pandemic. Moreover, the name of the journal had to be changed due to some administrative issues. However, the committed editorial team was successful in bringing efforts for the latest issue to fruition.

Synthesis, Structural Analysis and Pharmaceutical Screening of S-Substituted Derivatives of 1, 3, 4- Oxadiazole-2-Thiol and 1, 2, 4-Triazole-3-Thiol Having 4-Methylphenyl Sulfonyl Piperidine

Heterocyclic compounds are being focused by the organic and synthetic chemists because of their wide range of biological and other desirable applications. Five membered heterocyclic moieties, oxadiazoles and triazoles are among the most considered five membered heterocyclic cores for the production of new potential synthetic drugs. The most studied isomers of these heterocyclic moieties are 1,3,4- oxadiazole and 1,2,4-triazole owing to their potent pharmaceutical activities. Keeping in view the importance of 1,3,4-oxadiazole and 1,2,4-triazole heterocycles, a number of different S-substituted derivatives of 1,3,4-oxadiazole-2- thiol and 1,2,4-triazole-3-thiol having 4-methylphenyl sulfonyl piperidine have been synthesized and screened for the evaluation of pharmaceutical potential including antibacterial and enzyme inhibition. The antibacterial potential was evaluated against certain strains of Gram positive and Gram negative bacteria. Enzyme inhibition potential was evaluated against lipoxygenase (LOX) enzyme responsible for inflammation. The list of ninety seven (97) synthesized derivatives includes fifty seven (57) derivatives of 1,3,4-oxadiazole (7a-w, 11a-v, 14a-l) and forty (40) derivatives of 1,2,4-triazole (18a-t, 19a-t). The multistep protocols for all of these compounds have been described in five (5) schemes. The compound ethyl 1-tosylpiperidine-4- carboxylate (3) was synthesized by the reaction of 4-methylphenyl sulfonyl chloride (1) and ethyl isonipecotate (2) using 10% aqueous solution of Na2CO3 as reaction medium. The compound 3 was further converted into corresponding carbohydrazide (4) by hydrated hydrazine in methanol under reflux. 5-(1-(4-Methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5) was synthesized from compound (4) by reflux in ethanol in the presence of carbon disulfide (CS2) in basic medium. Twenty three (23) alkyl/aralkyl derivatives of 1,3,4-oxadiazole-2-thiol having 4-methylphenyl sulfonyl piperidine were synthesized (7a-w, Scheme-1) by the reaction of 5 and 6a-w. N-Substituted alkyl/aralkyl amines (8a-v) were made to react with 2-bromoacetyl bromide (9) to synthesize 2-bromo-N-substituted acetamides (10a-v) as electrophiles. The synthesized 1,3,4-oxadiazole-2-thiol (5) was further derivatized by these electrophiles (10a-v) to synthesize twenty two (22) N-substituted acetamide derivatives (11a-v, Scheme-2). N-substituted alkyl/aralkyl amines (8a-g,j,m,n,p,v) were made to react with 3-bromopropionyl bromide (12) to synthesize 3-bromo-Nsubstituted propanamides (13a-l). Again the synthesized 1,3,4-oxadiazole-2-thiol (5) was derivatized with these electrophiles (13a-l) to synthesize twelve (12) Nsubstituted propanamides (14a-l, Scheme-3). Compound 4 was refluxed with isothiocyanatobenzene (15) in methanol to produce N-phenyl-2-(1-4- methylphenylsulfonylpiperidine-4-carbonyl)hydrazine carbothioamide (16). The compound 16 was cyclized to 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3- thiol (17) using 10% aqueous solution of NaOH as reaction medium. The synthesized 1,2,4-triazole-3-thiol (17) was used to produce twenty (20) derivatives (18a-t, Scheme-4) on reaction with different alkyl/aralkyl halides (6a-t) in a polar aprotic medium. The synthesized electrophiles, 2-bromo-N-substituted acetamides (10a-s,u), were stirred with the synthesized 1,2,4-triazole-3-thiol (17) to yield twenty (20) different N-substituted acetamide derivatives (19a-t, Scheme-5). Structures of all the synthesized compounds were confirmed using Infra Red (IR) spectroscopy, Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR) spectroscopy and Electron Impact Mass Spectrometry (EIMS) data. Ring formation of 1,3,4-oxadiazole and 1,2,4-triazole was confirmed through 13C-NMR. The determined physical data of all the target compounds includes physical state, color, yield, melting point, molecular formula and molecular mass which are given in results section (Chapter-4). The synthesized compounds were screened for antimicrobial potential against Gram-positive and Gram-negative bacterial strains. The results of antibacterial potential are given as % inhibition and minimum inhibitory concentration (MIC) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 7a, 7c and 7m remained the most active against P. aeruginosa, S. aureus and E. coli respectively and compound 7o against both of S. typhi and B. subtilis. All of these (7a, 7c, 7m, 7o) showed antibacterial activity comparable to that of the reference standard, Ciprofloxacin. Among the acetamide derivatives (11a-v) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 11c and 11s exhibited proficient activity against S. typhi and P. aeruginosa, respectively and compound 11d against three strains including E. coli, S. aureus and B. subtilis. These three most active compounds also showed activity comparable to that of Ciprofloxacin. Among the propanamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 14b showed efficient activity against B. subtilis and P. aeruginosa; compounds 14d, 14f and 14g against E. coli, S. aureus and S. typhi, respectively and also comparable to that of Ciprofloxacin. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4- phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), compound 18a executed better potential against four bacterial strains S. typhi, E. coli, B. subtilis and P. aeruginosa and 18c against S. aureus. The observed potential was also comparable to the reference. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), the most active compounds were 19a against S. typhi, 19d against E. coli, 19o against B. subtilis and 19h against P. aeruginosa with MIC value close to that of the reference. Lipoxygenase (LOX) inhibition potential was evaluated with reference to Baicalein, the reference standard. The enzyme inhibition activity results are given as % inhibition and concentration for 50% inhibition (IC50) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 7a, 7b and 7c with reference of the standard, Baicalein. Among the acetamide derivatives (11a-v) of 5-(1-(4-methylphenylsulfonyl)piperidin- 4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 11m, 11n and 11t. Among the propionamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), two the most potent inhibitors of LOX were 14e and 14f. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), three the most potent inhibitors of LOX were 18a, 18b and 18c. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole- 3-thiol (17), three the most potent inhibitors of LOX were 19g, 19n and 19r. The activity of all these compounds was compared to the reference, Baicalein. Furthermore, the molecular docking studies have been discussed in Chapter-4 for LOX inhibition activity. Overall a number of compounds exhibited moderate LOX inhibition potential as compared to reference standard, Baicalein. Many compounds showed excellent antibacterial potential. The most active compounds against bacterial strains might be suitable as new drug candidates in pharmaceutical industries to develop potent drugs for the different bacterial infection. The most active LOX inhibitors might be further forwarded as new drug candidates for inflammatory diseases.