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In Silico Characterization of Dna Repair Genes Oggi, Apei, Xrcc1 in Head and Neck Cancer

Thesis Info

Author

Muhammad Qasim Khan and Zubair Qaiser

Supervisor

Muhammad Faraz Arshad Malik

Department

Department of Biosciences

Program

BS

Institute

COMSATS University Islamabad

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2011

Thesis Completion Status

Completed

Subject

Biosciences

Language

English

Added

2021-02-17 19:49:13

Modified

2023-02-17 21:08:06

ARI ID

1676719612047

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انجمن پنجاب

تعارف:
اس انجمن کا پورا نام "انجمن اشاعت مطالب مفیدہ پنجاب" ہے یہ انجمن لاہور میں جنوری 1865 میں قائم ہوئی۔ محمدحسین آزاد اور ڈاکٹر لائٹنر نے کوششیں کی۔محمد حسین آزاد نے اپنے کچھ جدید اور اہم نظریات کو عملی صورت دینے کے لئے اس انجمن کو استعمال کیا اور اس سے لوگوں میں ایک فعال ادبی تحریک پیدا کی۔
انجمن پنجاب کے مقاصد:
انجمن پنجاب کے درجہ ذیل مقاصد تھے:
1 :قدیم مشرقی علوم کا احیائ۔
2 : صعنت و تجارت کا فروغ ۔
3: کے لوگوں میں دیسی زبان کے ذریعے علوم مفیدہ کی اشاعت کرنا ۔
4: علمی و ادبی ،معاشرتی اور سیاسی مسائل پر بحث کرنا۔
5:صوبے کے بارسوخ اہل علم طبقات اور افسران حکومت میں رابطہ قائم کرنا۔
6: پنجاب اور ہندوستان کے دوسرے فرقوں کے ساتھ روابط اور تعلقات کی مضبوطی۔
ادبی خدمات
محمد حسین آزاد اس انجمن کے روح رواں تھے اس انجمن سے پہلے مشاعرے کی روایت موجود تھی لیکن وہ روایت طرحی غزلوں کی تھی اس انجمن نے نئی طرح کے مشاعرے شروع کئے یعنی مختلف موضوعات پر نظمیں کہی جاتی تھیں ہر مشاعرے میں ایک موضوع دے دیا جاتا تھا جس پر مختلف شعراء لکھ کر لے آتے تھے اس لحاظ سے اس انجمن نے مشاعروں کی طرز میں ایک نیا رجحان پیدا کیا ان مشاعروں میں نظمیں پڑھی جاتی تھیں اس لیے ان کو مناظموں کا نام دیا گیا۔
موضوعی نظم لکھنے کا رجحان:
موضوعی نظم لکھنے کا اولین تجربہ آزاد نے نہیں کیا بلکہ اس سے پہلے زمانہ قدیم میں اس کی روایت موجود تھی مثلا سلطان محمد قلی قطب شاہ کی کلیات میں نظمیں ہیں اس کے علاوہ دکنی دور میں مثنویاں بھی لکھی گئیں۔جو نظم ہی کا ایک حصہ ہیں اس کے علاوہ نظیر اکبر آبادی نظم روایت میں بہت بڑے شاعر ہیں۔ان...

Efficacy, Safety and Tolerability of Valsartan and Hydrochlorothiazide Compared to Valsartan and Amlodipine in Stage 2 Hypertension

Background: Hypertension is a growing medical and public health issue. The United States and European treatment guidelines have been issued to attain smooth control of hypertension in various categories of patients. It is a need of time to unveil safe combination therapies in various populations. Objectives: (i) To determine the efficacy of valsartan and hydrochlorothiazide versus valsartan and amlodipine (ii) To determine the safety and tolerability of both combinations. Materials & Methods: This experimental study was conducted at Shalamar Hospital Lahore. 126 patients with stage 2 hypertension were recruited from the medical outdoor of Shalamar Hospital Lahore after getting informed consent. In group A, 63 patients were given valsartan and hydrochlorothiazide. In group B, 63 patients were given valsartan and amlodipine. Blood pressure (BP) of both study groups was recorded on day zero, 2nd, 4th, and 8th weeks and the readings were entered on a Proforma. The efficacy of drug combinations was accessed in both groups by recording the change in mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP). The safety and tolerability of the drug combinations were assessed in terms of side effects and laboratory findings. Results: In group A, there was a 39±7mmzHg and 18±1mmHg decrease in MSBP and MDBP, respectively, from baseline BP. In group B, there was a 26.7±4mmHg and 14±2 mmHg decrease in MSBP and MDBP, respectively, from baseline BP. Both combinations were safe, and no significant difference in the efficacy of both combinations was observed after 8-week of treatment. Conclusion: Both combinations are effective for control of BP, but the valsartan and hydrochlorothiazide combination (group A) appears to have better tolerability and greater effect in decreasing BP as compared to the combination of valsartan and amlodipine (group B), although this difference is not statistically significant.  

Detection of Babesia Ovis Through Polymerase Chain Reaction in Sheep and Goat from District Bahawalpur

The infection of Ovine babesia is considered as a tick-borne disease that is caused by a haematotropic parasite belonging to the genus babesia. Main infection in small ruminants (goat and sheep) is caused by three babesia species. The sickness caused by genus Babesia ovis (B .ovis) is very horrific mostly in goat and sheep and causes rigorous infection that is characterized by fever, anemia. The present study was carried on to become aware of B.ovis through PCR within the blood samples of small ruminants at Bahawalpur district. Total one Hundred blood samples of sheep and goat randomly were gathered from different areas of district Bahawalpur. Blood smear slides were prepared and analyzed through microscope. DNA was extracted by inorganic method. PCR amplification was done using specific set of primers for babesia species and results were studied through gel electrophoresis. Overall prevalence of babesia species was 18% by microscopy. Area wise percentages of microscopy tests were also calculated. 18% (18/100)Jamalpur 10% (1/10), Hasilpur 30%( 3/10), Khairpur 10% (1/10), Qaimpur 10% (1/10), Lal sohanra 20% (2/10), Lal sohanra park 30% (3/10), Yazman mandi 10%( 1/10), Rajkan 20% (2/10), Ahmad pur East 20%( 2/10), Uch Sharif 20% (2/10). PCR showed11% (11/100) positive result in sheep and goat (10% (1/10) in Jamalpur, 20% (2/10) in Khairpur 10% (1/10) in Qaimpur , 0% (0/10) in Lal sohanra , 10% (1/10) in Lalsohara park , 20% (2/10) in Yazman mandi 0%(0/10), Rajkan 10%(1/10), Ahmad pur 10%(1/10) and in Uch sharif 20%(2/10). The specificity and sensitivity of PCR was 100% in findings of B.ovis as compared to microscopy which showed 18% (18/100) sensitivity and 100% specificity was pragmatic. The study reveals that PCR is the additional sensitive technique in designation against babesiosis as compared to research and counseled it for field application in district Bahawalpur, Punjab, Pakistan. However, safety measures are required in order to domesticate the small ruminants like sheep and goat from such pathogenic parasites.